Protein Alignment Shab and Kcng2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001100842.1
• Gene: Kcng2 / 307234
• RGDID: 1309521
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 451
• Identity: 157/451 - (34%)
• Similarity: 253/451 - (56%)
• Gaps: 25/451 - (5%)

  Fly   291 IPPPEPFMIAQ----SKAVNSR-VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCD 350
            :|..||....:    .:...:| |.|||||.|..:.|..|.|.|..||.|||.|..|:.::.:||
  Rat    10 VPGAEPGSAVRGGRGGRGARARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDELLRVCD 74

  Fly   351 DYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQ 415
            ||.::.:|:||||.|.:|.:|:...|.|||.::...|.|||.|:|.|||:||..||.||..:..:
  Rat    75 DYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRR 139

  Fly   416 RKENVHE-EMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |:|...| .....|...:.......|.|:....::.|.:::|.|::..|.::.|.:|:.|:.::.
  Rat   140 REEEAAEARATPPARGPQTSPGRALGSGRLERGRRRLRDVVENPHSGLAGKLFAYVSVAFVAVTA 204

  Fly   480 IALTLNTLPQLQHIDN----GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNII 540
            :.|.|:|:|.::..:.    .|...|  |.::|.||:.||:.|::||...:..|..|.:..|.||
  Rat   205 VGLCLSTMPDVRAEEERGECSTKCRN--LFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLAII 267

  Fly   541 DLLAILPYFVSLFL-LETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSY 604
            |:|||||::|||.. |......:...:....|:::.|.:|:|.:::|||||.||:|||.|:|...
  Rat   268 DILAILPFYVSLLAGLAAGPTGSKMLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCA 332

  Fly   605 KELGLLMLFLAMGVLIFSSLAYFAEKD---EKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALG 666
            :|.|||:|||.:.:.:|:.|.:.||::   .:|  |.|:|.::|||.|:||||||||:.|.:..|
  Rat   333 REFGLLLLFLCVAMALFAPLVHLAERELGAHRD--FSSVPASYWWAVISMTTVGYGDMVPRSLPG 395

  Fly   667 KVIGTVCCICGVLVIALPIPIIVNNFAEFY---KNQMRR----EKALKRREALDRAKREGS 720
            :|:.....:.|:|::|.|:..|.:.|:..|   |.|.:|    |..|:.....|.:.|..|
  Rat   396 QVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPVLREDSTRDDSTRSAS 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	50/108 (46%)
		Ion_trans	464..700	CDD:459842	87/246 (35%)
Kcng2	NP_001100842.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		3/14 (21%)
		BTB_POZ_Kv6_KCNG	33..127	CDD:349691	44/93 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..167		3/22 (14%)
		Ion_trans	190..429	CDD:459842	86/242 (36%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	382..387		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..480		8/28 (29%)