DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcng2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001100842.1	Gene:	Kcng2 / 307234	RGDID:	1309521	Length:	480	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	157/451 - (34%)
Similarity:	253/451 - (56%)	Gaps:	25/451 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 IPPPEPFMIAQ----SKAVNSR-VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCD 350
            :|..||....:    .:...:| |.|||||.|..:.|..|.|.|..||.|||.|..|:.::.:||
  Rat    10 VPGAEPGSAVRGGRGGRGARARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDELLRVCD 74

  Fly   351 DYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQ 415
            ||.::.:|:||||.|.:|.:|:...|.|||.::...|.|||.|:|.|||:||..||.||..:..:
  Rat    75 DYDVSRDEFFFDRSPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRR 139

  Fly   416 RKENVHE-EMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |:|...| .....|...:.......|.|:....::.|.:::|.|::..|.::.|.:|:.|:.::.
  Rat   140 REEEAAEARATPPARGPQTSPGRALGSGRLERGRRRLRDVVENPHSGLAGKLFAYVSVAFVAVTA 204

  Fly   480 IALTLNTLPQLQHIDN----GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNII 540
            :.|.|:|:|.::..:.    .|...|  |.::|.||:.||:.|::||...:..|..|.:..|.||
  Rat   205 VGLCLSTMPDVRAEEERGECSTKCRN--LFVLETVCVAWFSFEFLLRSLQAESKCAFLRTPLAII 267

  Fly   541 DLLAILPYFVSLFL-LETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSY 604
            |:|||||::|||.. |......:...:....|:::.|.:|:|.:::|||||.||:|||.|:|...
  Rat   268 DILAILPFYVSLLAGLAAGPTGSKMLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCA 332

  Fly   605 KELGLLMLFLAMGVLIFSSLAYFAEKD---EKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALG 666
            :|.|||:|||.:.:.:|:.|.:.||::   .:|  |.|:|.::|||.|:||||||||:.|.:..|
  Rat   333 REFGLLLLFLCVAMALFAPLVHLAERELGAHRD--FSSVPASYWWAVISMTTVGYGDMVPRSLPG 395

  Fly   667 KVIGTVCCICGVLVIALPIPIIVNNFAEFY---KNQMRR----EKALKRREALDRAKREGS 720
            :|:.....:.|:|::|.|:..|.:.|:..|   |.|.:|    |..|:.....|.:.|..|
  Rat   396 QVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPEPVLREDSTRDDSTRSAS 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	49/106 (46%)
		BTB_2	309..408	CDD:280393	47/98 (48%)
		Ion_trans	501..700	CDD:278921	79/205 (39%)
		Ion_trans_2	613..696	CDD:285168	31/85 (36%)
Kcng2	NP_001100842.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		3/14 (21%)
		BTB_POZ_Kv6_KCNG	33..127	CDD:349691	44/93 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..167		3/22 (14%)
		Ion_trans	190..429	CDD:395416	86/242 (36%)
		Selectivity filter. /evidence=ECO:0000250	382..387		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..480		8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020