Protein Alignment Shab and Kcnf1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001162575.1
• Gene: Kcnf1 / 298908
• RGDID: 631414
• Length: 505
• Species: Rattus norvegicus
• Alignment Length: 575
• Identity: 195/575 - (33%)
• Similarity: 291/575 - (50%)
• Gaps: 113/575 - (19%)

  Fly   274 SNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRE 338
            |..|.::..:..:|:     |||.........:..:.:||||||..:....|.:.|.|||..|..
  Rat     7 SEPTRSMDASAEQSL-----PEPGSQDSVAGDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELIN 66

  Fly   339 CTT--HEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVD 401
            |..  ::.|..|||||.....|::|||.|.:|..::..|..|::|:...:|.:.|.:::::|.||
  Rat    67 CLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVD 131

  Fly   402 ELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARV 466
            ..:|:.||:....:::|.: ||:.:..:.:......:..||:....||.:|:.||||.:|..|||
  Rat   132 LKFLDDCCKSHLSEKREEL-EEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARV 195

  Fly   467 IAVISILFIVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKW 530
            :||:|.|.|::|::.:.:.|:|:||.:|: |...::|.|..||..||.||||||:||..:||:|.
  Rat   196 VAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKL 260

  Fly   531 KFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQS 595
            .|....:||:|:|||||::|||.|........ :..:|::.||..|||||.||.||||||:|||:
  Rat   261 HFALSFMNIVDVLAILPFYVSLTLTHLGARMM-ELTNVQQAVQALRIMRIARIFKLARHSSGLQT 324

  Fly   596 LGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIY 660
            |.:.|:.|:||||||:::||:|:.:||:|.|..|:...:|.|.|||::||||.||||||||||||
  Rat   325 LTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIY 389

  Fly   661 PTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFH 725
            |.|.|||:...:..:|||:.|||||..|:|||..:|..|...|.|.|
  Rat   390 PKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAK------------------ 436

  Fly   726 HINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEG 790
                                                                |.|...:.||:..
  Rat   437 ----------------------------------------------------HELELMELNSSSA 449

  Fly   791 ESTSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQ 845
            ||..|                             ||.|:.|.:||    .|.||:
  Rat   450 ESKPG-----------------------------GSRSDLDTLPP----EPAARE 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	36/109 (33%)
		Ion_trans	464..700	CDD:459842	120/236 (51%)
Kcnf1	NP_001162575.1	BTB_POZ_Kv5_KCNF1	35..150	CDD:349690	37/114 (32%)
		Ion_trans	193..429	CDD:459842	120/236 (51%)