Protein Alignment Shab and Kcna3

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_062143.3
• Gene: Kcna3 / 29731
• RGDID: 2951
• Length: 525
• Species: Rattus norvegicus
• Alignment Length: 646
• Identity: 188/646 - (29%)
• Similarity: 281/646 - (43%)
• Gaps: 168/646 - (26%)

  Fly   169 GGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEVRYAPFPV 233
            |.||..|.|            ||.|.|....|           |..||.|..      ||.|.|.
  Rat     6 GDHLLEPEA------------AGGGGGDPPQG-----------GCVSGGGCD------RYEPLPP 41

  Fly   234 ASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFM 298
            |.|                     .|..|...|
  Rat    42 ALP---------------------AAGEQDCCG-------------------------------- 53

  Fly   299 IAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEY 359
                    .||.||:.|:|.|...:||.:.|.|.||    |:|.             :....|||
  Rat    54 --------ERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRY-------------FDPLRNEY 97

  Fly   360 FFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEE 423
            ||||:..||.:||.:|:: |::.....:.:..||:::.::.:.|            :..|...|:
  Rat    98 FFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGE------------EAMEKFRED 150

  Fly   424 ---MRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLN 485
               :|:|...|.:||           :|:.:|.|.|.|.:|..||.||::|:|.|::|.:...|.
  Rat   151 EGFLREEERPLPRRD-----------FQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLE 204

  Fly   486 TLPQLQH----------------------IDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPD 528
            |||:.:.                      ..:|....:....:||.:||.||:.|.::||.|.|.
  Rat   205 TLPEFRDEKDYPASPSQDVFEAANNSTSGASSGASSFSDPFFVVETLCIIWFSFELLVRFFACPS 269

  Fly   529 KWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGL 593
            |..|.:..:|:||::||:|||::|......:....|......:::|.|::|:.||.||:|||.||
  Rat   270 KATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL 334

  Fly   594 QSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGD 658
            |.||.||:.|.:|||||:.||.:||::|||..||||.|:..:.|.|||:.||||.:|||||||||
  Rat   335 QILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGD 399

  Fly   659 IYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALK------------RREA 711
            ::|.|..||::|::|.|.|||.||||:|:||:||..||..:...|:..:            ..|.
  Rat   400 MHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEE 464

  Fly   712 LDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDV 772
            |.:|:...::....::.:::..............||..|..........|..||.:...||
  Rat   465 LRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	31/112 (28%)
		Ion_trans	464..700	CDD:459842	109/257 (42%)
Kcna3	NP_062143.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		9/28 (32%)
		BTB_POZ	54..180	CDD:453885	43/161 (27%)
		Ion_trans	183..440	CDD:459842	109/256 (43%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	394..399		4/4 (100%)
		Interaction with KCNE4. /evidence=ECO:0000269|PubMed:27802162	432..525		14/92 (15%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:7477295	523..525		0/1 (0%)