DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and Kcnq3

DIOPT Version :10

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_113785.4 Gene:Kcnq3 / 29682 RGDID:69222 Length:873 Species:Rattus norvegicus


Alignment Length:871 Identity:171/871 - (19%)
Similarity:301/871 - (34%) Gaps:247/871 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   443 KCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIAL-TLNTLPQLQHIDNGTPQDNPQLAM 506
            |....|..:::.||:|. .:|....|:  :..|||..:.| .|.|..:.:.:      ....|.:
  Rat   104 KYRRIQTLIYDALERPR-GWALLYHAL--VFLIVLGCLILAVLTTFKEYETV------SGDWLLL 159

  Fly   507 VEAVCITWFTLEYILRFSASP--DKWKFFKGG----------LNIIDLLAILPYFVSLFLLETNK 559
            :|...|..|..|:.||..|:.  .::|.::|.          |:|..|:|.:|  |.....:.|.
  Rat   160 LETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVP--VVAVGNQGNV 222

  Fly   560 NATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGV 618
            .||.        ::..|.::|||:|::.|.....:.||..:....|||      |.|.|.|:   
  Rat   223 LATS--------LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILS--- 276

  Fly   619 LIFSSLAYFAEKD---------EKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCC 674
               |.|.|..|||         |...:|.:..:..||..||:.|:||||..|.|..|::|.....
  Rat   277 ---SFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFS 338

  Fly   675 ICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR----EALDRAKR-----------------E 718
            :.||...|||..|:.:..|...:.|.|::...|||    |.:..|.|                 .
  Rat   339 LIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRLDLVATWRFY 403

  Fly   719 GSIVSFHHI---NLKDAFAKSMDLID-VIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779
            .|:|||...   .|:.|.::.:.|:| |.:...:.:|.   |||..:..|:..    ::.:|...
  Rat   404 ESVVSFPFFRKEQLEAAASQKLGLLDRVRLSNPRGSNT---KGKLFTPLNVDA----IEESPSKE 461

  Fly   780 LSQTDGNSTEGESTSGRNPA--------TTGTGCYKNYDHVANLRNSNLHNRRGSSSE---QDAV 833
            ......|:.|...|:.|..|        ..|||.....|             ||..::   :|.:
  Rat   462 PKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMTED-------------RGYGNDFLIEDMI 513

  Fly   834 PPYSFDNPNARQTSMMAMESYRR---------EQQALLQQQQQQQQQML-QMQQIQQKAPNGNGG 888
            |..   ....|...::....|::         :.:.:::|.......|| :::.:|.:       
  Rat   514 PTL---KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR------- 568

  Fly   889 ATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPI 953
                     :.|:......:......:...::.|.|..:...          ::..:::|.....
  Rat   569 ---------IDMIFTPGPPSTPKHKKSQKGSAFTYPSQQSPR----------NEPYVARAATSET 614

  Fly   954 QMMITPGEVAELRRQV--------ALENLQNQRMDNLEQDV-----------PVEFECCFCTTKD 999
            :.....|:..::.|||        .|.::..|.|:.|:..|           |.|.|     .|:
  Rat   615 EDQSMMGKFVKVERQVHDMGKKLDFLVDMHMQHMERLQVHVTEYYPTKGASSPAEGE-----KKE 674

  Fly  1000 FKEFTDAEGVISL--------PTSDFHK-PICLEMRLAAAGRQAGAYGLLSPLPAPLP------- 1048
            ...::|.:.:|..        |...||: ||          .:.|.||..:..|..|.       
  Rat   675 DNRYSDLKTIICNYSESGPPDPPYSFHQVPI----------DRVGPYGFFAHDPVKLTRGGPSST 729

  Fly  1049 ------PLHGPLLALPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTT------------------ 1089
                  |..|...|..|           .:||.::...|..|.:..|                  
  Rat   730 KAQANLPSSGSTYAERP-----------TVLPILTLLDSCVSYHSQTELQGPYSDHISPRQRRSI 783

  Fly  1090 ---TSTTIALPLDVSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADL 1151
               :.|.::|   :|:.:.....|.|.|  :.:.:.:....|..|..:.:....|......:.| 
  Rat   784 TRDSDTPLSL---MSVNHEELERSPSGF--SISQDRDDYVFGPSGGSSWMREKRYLAEGETDTD- 842

  Fly  1152 ASVDSSDTYASCQTHPFLSQGDLTAD 1177
                 :|.:....:.|..|.||..:|
  Rat   843 -----TDPFTPSGSMPMSSTGDGISD 863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720
Ion_trans 464..700 CDD:459842 69/263 (26%)
Kcnq3NP_113785.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
Ion_trans 122..364 CDD:459842 70/265 (26%)
Selectivity filter. /evidence=ECO:0000250 317..322 3/4 (75%)
Mediates interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:O43525 357..538 39/203 (19%)
KCNQ_channel 447..651 CDD:460954 32/249 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..603 2/37 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..742 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..873 16/109 (15%)
KCNQC3-Ank-G_bd 771..867 CDD:463411 16/104 (15%)
Blue background indicates that the domain is not in the aligned region.

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