DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcna10

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001178642.1	Gene:	Kcna10 / 295360	RGDID:	1304667	Length:	511	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	184/486 - (37%)
Similarity:	264/486 - (54%)	Gaps:	66/486 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 THSRSMSSIP-----PP--EPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECT 340
            :|..:.|.||     ||  ||.::.:.   |.||.||:.|:|.|...|||.:.|.|.||
  Rat    58 SHETAFSKIPGEYVDPPGSEPVVLNEG---NQRVIINIAGLRFETQLRTLNQFPETLLG------ 113

  Fly   341 THEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELY 404
            ..|..::..|...   |||||||:..||..||.:|:: ||:.....:.:..|:|::.::   ||.
  Rat   114 DREKRMQFFDSMR---NEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEISFY---ELG 172

  Fly   405 LESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAV 469
            .|:..|.:       ..|...|:.|:|...:          ::.:..|.|.|.|.:|.|||.:||
  Rat   173 SEAMDQFR-------EDEGFIKDPETLLPTN----------DFHRQFWLLFEYPESSSAARGVAV 220

  Fly   470 ISILFIVLSTIALTLNTLP------QLQHIDNGTPQDN----------PQLAMVEAVCITWFTLE 518
            :|:|.:|:|.....|.|||      :|:.:.:.|...|          ....|||:.||.|||.|
  Rat   221 VSVLVVVISITIFCLETLPEFREDRELKVVRDPTINTNKTGLSQTMFTDPFFMVESTCIVWFTFE 285

  Fly   519 YILRFSASPDKWKFFKGGLNIIDLLAILPYFVSL---FLLETNKNATDQFQDVRRVVQVFRIMRI 580
            .:|||...|.|..|||..:||||:::|:|||.:|   .:.||..:|.....  ..::::.|::|:
  Rat   286 LVLRFVVCPSKPDFFKNIMNIIDIISIIPYFATLITELVQETEPSAQQNMS--LAILRIIRLVRV 348

  Fly   581 LRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFW 645
            .||.||:|||.|||.||.||:.|.:|||||:.||.:||::|||..||||.||.::.|.|||:.||
  Rat   349 FRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFW 413

  Fly   646 WAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRRE 710
            ||.:|||||||||:.|||..||::||:|.|.|||.||||:|:||:||..||..:...|:......
  Rat   414 WAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKPNIPG 478

  Fly   711 ALDR-----AKREGSIVSFHHINLKDAFAKS 736
            .||:     ..|.||..|.:..|...:..||
  Rat   479 ELDKILNSMGSRTGSTESLNKTNSSRSAEKS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	35/107 (33%)
		BTB_2	309..408	CDD:280393	34/99 (34%)
		Ion_trans	501..700	CDD:278921	105/211 (50%)
		Ion_trans_2	613..696	CDD:285168	51/82 (62%)
Kcna10	NP_001178642.1	BTB_2	88..179	CDD:280393	34/102 (33%)
		BTB	88..171	CDD:197585	31/94 (33%)
		Ion_trans	267..467	CDD:278921	104/201 (52%)
		Ion_trans_2	382..458	CDD:285168	47/75 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810