DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and Kcnv2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001099840.1	Gene:	Kcnv2 / 294065	RGDID:	1309271	Length:	561	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	184/519 - (35%)
Similarity:	284/519 - (54%)	Gaps:	51/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 SPTHSIPTT-SQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTH-------------S 285
            |.|..:|.| |.|...|:..:|....|..||:   |..::.|....::...             .
  Rat    20 SETEDVPNTGSNQHRKSICSMGARTGSQASIA---PQWTEGNYNYYIEEDEDCGEEEDWKDDLAE 81

  Fly   286 RSMSSIPPPEPF-MIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349
            .:.....||.|. ....:....|.:.:||||..:::....|...|.||||||...|:....:.||
  Rat    82 ENQKPEGPPAPLDGHTDTPTQLSTLKVNVGGHSYQLECCELANYPKTRLGRLVTSTSRNCQLGLC 146

  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414
            |||....:||||||.|..|..|.|||.:|.|.:.||:|..:|.::|.||||...|...||:..:.
  Rat   147 DDYEAKTDEYFFDRDPAVFQLIYNFYTSGVLLVRDELCPRSFLEELGYWGVRLKYTPRCCRICFE 211

  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKY------LWELLEKPNTSFAARVIAVISIL 473
            :|::.:.|:::.:.| ||.:.:.|..|....:.:.|      ||.|:|||.:|.||:.:.|.|.|
  Rat   212 ERRDELSEQLKIQRE-LRAQAQAEEAEELFRDMRFYGPQRQRLWNLMEKPFSSVAAKAMGVASNL 275

  Fly   474 FIVLSTIALTLNTLPQLQH-IDNGTPQDNPQ--LAMVEAVCITWFTLEYILRFSASPDKWKFFKG 535
            |:::|.:||.|||:.::|| .:.||...:|:  |..||.:|:.:||||::||.:::|:..:|.:.
  Rat   276 FVLISVVALALNTVEEMQHQAEQGTGGGDPRPILEHVEMLCVAFFTLEFLLRLASTPNLRRFARS 340

  Fly   536 GLNIIDLLAILPYFVSLFL-------------------LETNKNATDQFQDVRRVVQVFRIMRIL 581
            .||::||:||||:::.|.|                   |||    ..:...|.:|:::.|:|||.
  Rat   341 ALNLVDLVAILPFYLQLLLECFTSEDQRHGKGSPREHDLET----VGRVGKVGQVLRIMRLMRIF 401

  Fly   582 RILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWW 646
            ||||||||||||::.|||||..|:::|.||||:.||:..||:..|..|.|...|.|.||...:||
  Rat   402 RILKLARHSTGLRAFGFTLRQCYQQVGCLMLFITMGIFSFSAAVYSVEHDVPGTNFTSILHAWWW 466

  Fly   647 AGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRRE 710
            |.::::||||||:||.|.||::...:|...|:::..:||.|:.|.|:::|......|....|||
  Rat   467 AAVSISTVGYGDMYPETHLGRLFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTAIRRE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	44/106 (42%)
		BTB_2	309..408	CDD:280393	42/98 (43%)
		Ion_trans	501..700	CDD:278921	88/219 (40%)
		Ion_trans_2	613..696	CDD:285168	33/82 (40%)
Kcnv2	NP_001099840.1	BTB	106..197	CDD:197585	39/90 (43%)
		BTB	106..197	CDD:295341	39/90 (43%)
		Ion_trans	304..520	CDD:278921	88/219 (40%)
		Ion_trans_2	433..508	CDD:285168	30/74 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920