Protein Alignment Shab and KCNV1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_055194.1
• Gene: KCNV1 / 27012
• HGNCID: 18861
• Length: 500
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 205/508 - (40%)
• Similarity: 318/508 - (62%)
• Gaps: 46/508 - (9%)

  Fly   277 TGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRL----- 336
            :|:|....|....|....||.      |:....::||||.|..:..:.|...||||||:|
Human    15 SGSLTSLDSSVFCSEGEGEPL------ALGDCFTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVA 73

  Fly   337 --RECTTHEAI---VELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLE 396
              |......|:   :|||||.:..||||||||..::|..:|::||||:||:::::|.|:|..:::
Human    74 SYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQ 138

  Fly   397 YWGVDELYLESCCQHKYHQRKENVHE--EMRKEAE--SLRQRDEEEFGEGKCAEYQKYLWELLEK 457
            |||:|||.::|||:.:|.:||| :.|  :.:|:.|  ..:...|::|.:|.|...::.||.:|||
Human   139 YWGIDELSIDSCCRDRYFRRKE-LSETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEK 202

  Fly   458 PNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILR 522
            |.:|.|||:..||||:|:|:|.|.:.|.: .:|..:      |...|.::|.|||:|||.|::||
Human   203 PGSSTAARIFGVISIIFVVVSIINMALMS-AELSWL------DLQLLEILEYVCISWFTGEFVLR 260

  Fly   523 FSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLE--TNKNATDQFQDVRRVVQVFRIMRILRILK 585
            |....|:.:|.:...||||||||||::::| |:|  :....|.:.::|.|:|||.|::|.||:||
Human   261 FLCVRDRCRFLRKVPNIIDLLAILPFYITL-LVESLSGSQTTQELENVGRIVQVLRLLRALRMLK 324

  Fly   586 LARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGIT 650
            |.||||||:|||.|:...|:|:|||:|||::|:.|||::.||||:...||.|.|:|..:|||..:
Human   325 LGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTS 389

  Fly   651 MTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRA 715
            |||||||||.|.|..||::..:|.:.|:||:||||.||.:.|:..|.....:|.|:::||||.:.
Human   390 MTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKL 454

  Fly   716 KREGSIVSFHHINLKDAFAKS-MDLIDVIVDTGKQTNVVHPKGK-RQSTPNIG 766
            .:..:..|:..:||:|.:|:| |:::.:             ||: |.||.:.|
Human   455 TKNIATDSYISVNLRDVYARSIMEMLRL-------------KGRERASTRSSG 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	48/117 (41%)
		Ion_trans	464..700	CDD:459842	112/237 (47%)
KCNV1	NP_055194.1	BTB_POZ	41..160	CDD:453885	50/118 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..189		5/20 (25%)
		Ion_trans	209..435	CDD:459842	111/233 (48%)
		Selectivity filter. /evidence=ECO:0000250	392..397		4/4 (100%)