Protein Alignment Shab and Kcnq5

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001128115.2
• Gene: Kcnq5 / 259273
• RGDID: 628848
• Length: 951
• Species: Rattus norvegicus
• Alignment Length: 1031
• Identity: 201/1031 - (19%)
• Similarity: 350/1031 - (33%)
• Gaps: 325/1031 - (31%)

  Fly   443 KCAEYQKYLWELLEKP-NTSFAARVIAVISILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLA 505
            |....|.||:.:||:| ..:|.....    :..:|...:.|:: :|:|  :|    |...:..|.
  Rat   106 KYRRVQNYLYNVLERPRGWAFVYHAF----VFLLVFGCLILSVFSTIP--EH----TKLASSCLL 160

  Fly   506 MVEAVCITWFTLEYILR-FSAS--------PDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKN- 560
            ::|.|.|..|.||:|:| :||.        ..:.:|.:....:||.:.::. .:::...:|..|
  Rat   161 ILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIA-SIAVVSAKTQGNI 224

  Fly   561 -ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS- 623
             ||...:.:       |.::|||::::.|.....:.||..:....||| :...::...||||||
  Rat   225 FATSALRSL-------RFLQILRMVRMDRRGGTWKLLGSVVYAHSKEL-ITAWYIGFLVLIFSSF 281

  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688
            |.|..||| .:.:|.:..:..||..||:||:||||..|.|.||:::.....:.|:...|||..|:
  Rat   282 LVYLVEKD-ANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGIL 345

  Fly   689 VNNFAEFYKNQMRREKALKRRE-------------ALDR---------------------AKREG 719
            .:.||...:.|.|::...|||.             |.|.                     .|.:|
  Rat   346 GSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQG 410

  Fly   720 SIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGK-RQSTPNIGRQTLDVQSAPGHNLSQT 783
            ...|....:.|..|.:       :..:.||:..:..|.: |.::|. |:.....|::.|...|.:
  Rat   411 EAASSKFCSNKQKFFR-------MYTSRKQSQKLSFKERVRMASPR-GQSIKSRQASVGDRRSPS 467

  Fly   784 DGNSTEGEST--------------------SGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSS- 827
            ...:.||..|                    ....|.|.       .|....|...::::.:|..
  Rat   468 TDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKTV-------IDADTALGIDDVYDEKGCQC 525

  Fly   828 --SEQDAVPPYSFDNPNARQTSMMAMESYRR---------EQQALLQQQQQQQQQML-QMQQIQQ 880
              |.:|..||.   ....|...:|.....:|         :.:.:::|.......|| :::.:|.
  Rat   526 DVSVEDLTPPL---KTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQT 587

  Fly   881 KAPN--GNGGATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDD 943
            :...  |.|            .:.:...:....||.:.:..                       |
  Rat   588 RVDQILGKG------------QITSDKKSREKITAEHETTT-----------------------D 617

  Fly   944 NLSQAKGLPIQMMITPGEVAELRRQV-ALENLQNQRMDNLEQ---------------DVPVEFEC 992
            :||..           |.|.::.:|| ::|:..:..:|..:|               .:| .|||
  Rat   618 DLSML-----------GRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLTSFQIP-PFEC 670

  Fly   993 CFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMR-LAAAGRQAGAYGLLSPLPAPLPPLHGPLLA 1056
                               ..|||:..|:  |.: |:::.:.:|
  Rat   671 -------------------EQTSDYQSPV--ESKDLSSSAQNSG--------------------- 693

  Fly  1057 LPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTTTSTTIALPLDVSLRYGATICSSSNFNHNYNNN 1121
                              .:|:|:|.:.|.|.   ..|..|.:.|.:   |..:.|...|:
  Rat   694 ------------------CLSRSASANISRGL---QFILTPNEFSAQ---TFYALSPTMHS---- 730

  Fly  1122 FNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDSSDTYASCQTHPFLSQGDLTADFNDEACALD 1186
             .||.|....|.    |.:...:||....:::........:.|..|.||.
  Rat   731 -QTTQVPMSQND----GSSVVATNNLANQISAAPKPAAPTTLQIPPPLSA--------------- 775

  Fly  1187 IDMDNLYINPLEREQ---------HQGISSSTGFIVGLPSTNSSGGPRAQVKKSASGDTALRNLA 1242
                   |..|.|.:         |:.||..|..:|         ..:..|:.:.|..|..|:|.
  Rat   776 -------IKHLSRPEPLLSNPPGVHESISDVTTCLV---------ASKENVQFAQSNLTKDRSLR 824

  Fly  1243 ----AGGVGAGGLSPL--NDVYQSFDVQERGSRVSLNENSVPKHRKTRFQQSFTAMRPSGATGVL 1301
                .||.....:.|:  .|:.:|..||          |.:....:...|  |:....||:.|
  Rat   825 KSFDMGGETLLSVRPMVPKDLGKSLSVQ----------NLIRSTEELNLQ--FSGSESSGSRG-- 875

  Fly  1302 GSSVLGGMRPRARFEDTKLDDETGGRREGELAGGSGSPAASGSGGLSGQGPKKKRS 1357
                .....|:.|.....:.||..|..|.|.....|:|..:|....|....:..||
  Rat   876 ----SQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGEAAFSSDSLRTGRS 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	67/248 (27%)
Kcnq5	NP_001128115.2	Ion_trans	125..357	CDD:459842	68/251 (27%)
		KCNQ_channel	465..653	CDD:460954	34/243 (14%)