Protein Alignment Shab and Kcnb1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_037318.2
• Gene: Kcnb1 / 25736
• RGDID: 2954
• Length: 857
• Species: Rattus norvegicus
• Alignment Length: 996
• Identity: 432/996 - (43%)
• Similarity: 566/996 - (56%)
• Gaps: 193/996 - (19%)

  Fly   285 SRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349
            |||.||: ||||..|.:|||.:.||.:||||:.||||||||:|||.||||:||:|.||::::::|
  Rat    10 SRSTSSL-PPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLQVC 73

  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414
            |||||.||||||||||.:|:|||||||||:||:::|||.|:||.:|:|||:||:|||||||.:||
  Rat    74 DDYSLEDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYH 138

  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |:||.::||:::|||:||:|:.|||....|||.:|.||:||||||:|.||:::|:|||:||||||
  Rat   139 QKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLST 203

  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543
            |||:|||||:||.:|. |...||||||.||||||.|||:||:|||.:||.|||||||.||.||||
  Rat   204 IALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLL 268

  Fly   544 AILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELG 608
            |||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.||.|||
  Rat   269 AILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELG 332

  Fly   609 LLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVC 673
            ||:||||||::|||||.:||||||.||||.|||.:||||.|||||||||||||.|.|||::|.:|
  Rat   333 LLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLC 397

  Fly   674 CICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMD 738
            ||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :|:|||||:|::
  Rat   398 CIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNMKDAFARSIE 459

  Fly   739 LIDVIVDTGKQTNVVHPKGKRQS---TPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPAT 800
            ::|::|:  |....:..|.|.|.   :||..:.|....|                |::|.::..|
  Rat   460 MMDIVVE--KNGESIAKKDKVQDNHLSPNKWKWTKRALS----------------ETSSSKSFET 506

  Fly   801 TGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALLQQQ 865
            ...|              :....|.|||.|         :.|.:|...|..:..:.:.|.:|..:
  Rat   507 KEQG--------------SPEKARSSSSPQ---------HLNVQQLEDMYSKMAKTQSQPILNTK 548

  Fly   866 QQ--QQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAAS---SAATAVATATNASNA------ 919
            :.  |.:...:::.....:|.....|...||.:..:|.:..   |.||....||..|::
  Rat   549 EMAPQSKPPEELEMSSMPSPVAPLPARTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLASLS 613

  Fly   920 ----SNTAP--GSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVALENLQNQR 978
                |:|||  |..||.|   ..||.:.:.|       ||......|...|..|
  Rat   614 SKAGSSTAPEVGWRGALG---ASGGRLTETN-------PIPETSRSGFFVESPR----------- 657

  Fly   979 MDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSD-FHKPICLEMRLAAAGRQAGAYGLLSP 1042
             .:::.:.|::......      .|.:.:....||:.. :|.|  |..|..||...||
  Rat   658 -SSMKTNNPLKLRALKV------NFVEGDPTPLLPSLGLYHDP--LRNRGGAAAAVAG------- 706

  Fly  1043 LPAPLPPLHGPLLALPPPPPLPPTSCAAVL-LPAISQSSSTSSSYGTTT-------STTIALPLD 1099
                                   ..||::| .|.:|..||..::....|       .|.||.
  Rat   707 -----------------------LECASLLDKPVLSPESSIYTTASARTPPRSPEKHTAIAF--- 745

  Fly  1100 VSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDSS---DTYA 1161
                         ||....::..:|.|   ...|.||:               |||||   ..:.
  Rat   746 -------------NFEAGVHHYIDTDT---DDEGQLLY---------------SVDSSPPKSLHG 779

  Fly  1162 SCQTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGISSSTGFIVGLPSTNSSGGPRA 1226
            |  |.|..|.|..|...:.|:..|.....  ::.|      ..:.||.|.        :..||.|
  Rat   780 S--TSPKFSTGARTEKNHFESSPLPTSPK--FLRP------NCVYSSEGL--------TGKGPGA 826

  Fly  1227 QVKKSASGDTA--LRNLAAGG 1245
            |.|......|.  :..|..||
  Rat   827 QEKCKLENHTPPDVHMLPGGG 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	73/107 (68%)
		Ion_trans	464..700	CDD:459842	181/236 (77%)
Kcnb1	NP_037318.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		8/11 (73%)
		BTB_POZ_KCNB2	15..141	CDD:349719	85/126 (67%)
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	59..75		6/15 (40%)
		Ion_trans	188..424	CDD:459842	181/236 (77%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000269|PubMed:18463252, ECO:0000269|PubMed:19690160	448..481		13/34 (38%)
		Kv2channel	467..678	CDD:397541	52/277 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..524		15/86 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..569		3/28 (11%)
		FFAT. /evidence=ECO:0000250|UniProtKB:Q14721	590..596		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..658		16/69 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..802		10/33 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	818..857		10/38 (26%)