Protein Alignment Shab and Kcnc1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_036988.1
• Gene: Kcnc1 / 25327
• RGDID: 2955
• Length: 585
• Species: Rattus norvegicus
• Alignment Length: 493
• Identity: 176/493 - (35%)
• Similarity: 256/493 - (51%)
• Gaps: 80/493 - (16%)

  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSS 370
            :.|:.|||||.||:....||..||.|||..|.|...|...     ||....:|:||||||..|:.
  Rat     7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAH 66

  Fly   371 ILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESL---- 431
            |||:|||||||...::|...:.::|.:||:||..:|.||...|.|     |.:..:..:|.
  Rat    67 ILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQ-----HRDAEEALDSFGGAP 126

  Fly   432 ---RQRDEEEFGEGKCAE---------------------------YQKYLWELLEKPNTSFAARV 466
               ...|.:..|.|...:                           :|..:|.|.|.|.:|..||.
  Rat   127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARY 191

  Fly   467 IAVISILFIVLSTIALTLNT---------LPQLQHIDNGT-------PQDNPQLAMVEAVCITWF 515
            :|..|:.||::|.....|.|         ..:::::.|||       .:....|..:|.||:.||
  Rat   192 VAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWF 256

  Fly   516 TLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRI 580
            |.|:::|....|:|.:|.|..|||||.:||||:::.:.|...:..|.   :||...::|.|.:||
  Rat   257 TFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAA---KDVLGFLRVVRFVRI 318

  Fly   581 LRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEK---------DEKDTK 636
            |||.||.||..||:.||.|||.|..|..||::|||:|||||:::.|:||:         ..:.|.
  Rat   319 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTH 383

  Fly   637 FVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMR 701
            |.:||..||||.:||||:||||:||.|..|.::|.:|.:.|||.||:|:|:|||||..:|...|.
  Rat   384 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMA 448

  Fly   702 REK-ALKRREALDRAKREGS-------IVSFHHINLKD 731
            ::| ..|:::.:.|..:.||       :.|.||....|
  Rat   449 KQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSD 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	47/107 (44%)
		Ion_trans	464..700	CDD:459842	106/260 (41%)
Kcnc1	NP_036988.1	BTB_KCNC1_3	6..122	CDD:349721	50/124 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147		4/25 (16%)
		Ion_trans	189..447	CDD:459842	106/260 (41%)
		Selectivity filter. /evidence=ECO:0000250	400..405		3/4 (75%)