Protein Alignment Shab and Kcng1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001074603.1
• Gene: Kcng1 / 241794
• MGIID: 3616086
• Length: 514
• Species: Mus musculus
• Alignment Length: 455
• Identity: 172/455 - (37%)
• Similarity: 280/455 - (61%)
• Gaps: 31/455 - (6%)

  Fly   279 ALQRTHSRSMSSIPPPEPFMIAQSKAVNSR---VSINVGGVRHEVLWRTLERLPHTRLGRLRECT 340
            |::....|....:.|.:.  :.||.::..|   :.|||||:::.:.|.||:..|.||||:|:.||
Mouse    34 AIKGVFYRRAQRLRPQDD--LHQSCSLGDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQLKACT 96

  Fly   341 THEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYL 405
            ..:.|:.:||||.:..||:||||:|.:|.:||.|.|.|||.::.|||.|:|.::|.|||:.|.:|
Mouse    97 NFDDILSVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHL 161

  Fly   406 ESCCQHKYHQRKENVHEEMRKEAES--LRQRDEEEFG----EGKCAEYQKYLWELLEKPNTSFAA 464
            :.||:.:|.|:.|...|.|.:|.|.  |...|:|..|    ||:.:...:.|.:::|:|::....
Mouse   162 DGCCKRRYLQKIEEFAEMMEREEEEEPLDSEDQESEGPSASEGRLSRCMRRLRDMVERPHSGLPG 226

  Fly   465 RVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLA-------MVEAVCITWFTLEYILR 522
            :|.|.:|:||:.::.:.|:::|||.|:.     .::..|.:       :||:||:.||:||::||
Mouse   227 KVFACLSVLFVTVTAVNLSVSTLPSLRE-----EEEQGQCSQMCHNVFIVESVCVGWFSLEFLLR 286

  Fly   523 FSASPDKWKFFKGGLNIIDLLAILPYFVSLFL----LETNKNAT-DQFQD-VRRVVQVFRIMRIL 581
            |..:|.|:.|.:..|.:|||:|||||:|:|.:    ....|.:| :.:.| |..|::|.|.:|||
Mouse   287 FIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALRIL 351

  Fly   582 RILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDT-KFVSIPETFW 645
            .:::|||||.|||:||.|.|...:|.|||:|||.:.:.:|:.|.|..|.:..|: :|.|||..:|
Mouse   352 YVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYW 416

  Fly   646 WAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFY-KNQMRREKALKRR 709
            ||.||||||||||:.|.:..|:|:.....:.|:|::|.|:..|.:.|:..| :.:..:|:.|.||
Mouse   417 WAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVLIRR 481

  Fly   710  709
            Mouse   482  481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	50/110 (45%)
		Ion_trans	464..700	CDD:459842	97/250 (39%)
Kcng1	NP_001074603.1	BTB_POZ_KCNG1_2	60..173	CDD:349728	52/112 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..205		8/24 (33%)
		Ion_trans	227..471	CDD:459842	97/248 (39%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	424..429		4/4 (100%)