Protein Alignment Shab and Kcnq5

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001153611.1
• Gene: Kcnq5 / 226922
• MGIID: 1924937
• Length: 952
• Species: Mus musculus
• Alignment Length: 813
• Identity: 162/813 - (19%)
• Similarity: 283/813 - (34%)
• Gaps: 228/813 - (28%)

  Fly   443 KCAEYQKYLWELLEKP-NTSFAARVIAVISILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLA 505
            |....|.||:.:||:| ..:|.....    :..:|...:.|:: :|:|  :|    |...:..|.
Mouse   108 KYRRVQNYLYNVLERPRGWAFVYHAF----VFLLVFGCLILSVFSTIP--EH----TKLASSCLL 162

  Fly   506 MVEAVCITWFTLEYILR-FSAS--------PDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKN- 560
            ::|.|.|..|.||:|:| :||.        ..:.:|.:....:||.:.::. .:::...:|..|
Mouse   163 ILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIA-SIAVVSAKTQGNI 226

  Fly   561 -ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS- 623
             ||...:.:       |.::|||::::.|.....:.||..:....||| :...::...||||||
Mouse   227 FATSALRSL-------RFLQILRMVRMDRRGGTWKLLGSVVYAHSKEL-ITAWYIGFLVLIFSSF 283

  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688
            |.|..||| .:.:|.:..:..||..||:||:||||..|.|.||:::.....:.|:...|||..|:
Mouse   284 LVYLVEKD-ANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGIL 347

  Fly   689 VNNFAEFYKNQMRREKALKRRE-------------ALDR---------------------AKREG 719
            .:.||...:.|.|::...|||.             |.|.                     .|.:|
Mouse   348 GSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQG 412

  Fly   720 SIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGK-RQSTPNIGRQTLDVQSAPGHNLSQT 783
            ...|....:.|..|.:       :..:.||:..:..|.: |.::|. |:.....|::.|...|.:
Mouse   413 EASSSKFCSNKQKFFR-------VYTSRKQSQKLSFKERVRMASPR-GQSIKSRQASVGDRRSPS 469

  Fly   784 DGNSTEGEST----------------------SGRNP---ATTGTGCYKNYDH------------ 811
            ...:.||..|                      |...|   |.|..|....||.
Mouse   470 TDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGIDDVYDEKGCQCDVSVEDL 534

  Fly   812 -------VANLRNSNLHNRRGSSSE-------QDAVPPYSFDNPN--ARQTSMMA---------- 850
                   :..:|....|..:....|       :|.:..||..:.:  .|..|:..
Mouse   535 TPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQ 599

  Fly   851 MESYRREQQALLQQQQQQQQQML---------QMQQIQQKAPNGNGGATGGGVANNLAMVAASSA 906
            |.|.::.::.:..:.:......:         |:|.|:.|.         ..:.:....|....:
Mouse   600 MTSDKKSREKITAEHETTDDPSMLARVVKVEKQVQSIESKL---------DCLLDIYQQVLRKGS 655

  Fly   907 ATAVATAT--------NASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVA 963
            |:|:..|:        ..::...:...|:...|.....|......:.:.::||  |.::||.|.:
Mouse   656 ASALTLASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLTRSASANISRGL--QFILTPNEFS 718

  Fly   964 ELRRQVALENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLA 1028
            ..........:.:|     ...||:             ...|...|::  |::....|
Mouse   719 AQTFYALSPTMHSQ-----ATQVPM-------------SQNDGSSVVA--TNNIANQI------- 756

  Fly  1029 AAGRQAGAYGLLSPLPAPLPPLHGPLLALPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTTTSTT 1093
                        |..|.|..|     ..|..||||......:...|.:|..:....|....|:..
Mouse   757 ------------SAAPKPAAP-----TTLQIPPPLSAIKHLSRPEPLLSNPTGLQESISDVTTCL 804

  Fly  1094 IA-----------LPLDVSLRY-----GATICS 1110
            :|           |..|.|||.     |.|:.|
Mouse   805 VASKESVQFAQSNLTKDRSLRKSFDMGGETLLS 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	67/248 (27%)
Kcnq5	NP_001153611.1	Ion_trans	127..359	CDD:459842	68/251 (27%)
		Interaction with CALM. /evidence=ECO:0000250|UniProtKB:Q9NR82	371..379		0/7 (0%)
		KCNQ_channel	467..654	CDD:460954	26/195 (13%)
		Interaction with CALM. /evidence=ECO:0000250|UniProtKB:Q9NR82	541..548		1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..617		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	897..952