DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shab and Kcnq5

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_001153611.1 Gene:Kcnq5 / 226922 MGIID:1924937 Length:952 Species:Mus musculus


Alignment Length:813 Identity:162/813 - (19%)
Similarity:283/813 - (34%) Gaps:228/813 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   443 KCAEYQKYLWELLEKP-NTSFAARVIAVISILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLA 505
            |....|.||:.:||:| ..:|.....    :..:|...:.|:: :|:|  :|    |...:..|.
Mouse   108 KYRRVQNYLYNVLERPRGWAFVYHAF----VFLLVFGCLILSVFSTIP--EH----TKLASSCLL 162

  Fly   506 MVEAVCITWFTLEYILR-FSAS--------PDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKN- 560
            ::|.|.|..|.||:|:| :||.        ..:.:|.:....:||.:.::. .:::...:|..| 
Mouse   163 ILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIA-SIAVVSAKTQGNI 226

  Fly   561 -ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS- 623
             ||...:.:       |.::|||::::.|.....:.||..:....||| :...::...|||||| 
Mouse   227 FATSALRSL-------RFLQILRMVRMDRRGGTWKLLGSVVYAHSKEL-ITAWYIGFLVLIFSSF 283

  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688
            |.|..||| .:.:|.:..:..||..||:||:||||..|.|.||:::.....:.|:...|||..|:
Mouse   284 LVYLVEKD-ANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGIL 347

  Fly   689 VNNFAEFYKNQMRREKALKRRE-------------ALDR---------------------AKREG 719
            .:.||...:.|.|::...|||.             |.|.                     .|.:|
Mouse   348 GSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQG 412

  Fly   720 SIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGK-RQSTPNIGRQTLDVQSAPGHNLSQT 783
            ...|....:.|..|.:       :..:.||:..:..|.: |.::|. |:.....|::.|...|.:
Mouse   413 EASSSKFCSNKQKFFR-------VYTSRKQSQKLSFKERVRMASPR-GQSIKSRQASVGDRRSPS 469

  Fly   784 DGNSTEGEST----------------------SGRNP---ATTGTGCYKNYDH------------ 811
            ...:.||..|                      |...|   |.|..|....||.            
Mouse   470 TDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKPVIDADTALGIDDVYDEKGCQCDVSVEDL 534

  Fly   812 -------VANLRNSNLHNRRGSSSE-------QDAVPPYSFDNPN--ARQTSMMA---------- 850
                   :..:|....|..:....|       :|.:..||..:.:  .|..|:..          
Mouse   535 TPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQ 599

  Fly   851 MESYRREQQALLQQQQQQQQQML---------QMQQIQQKAPNGNGGATGGGVANNLAMVAASSA 906
            |.|.::.::.:..:.:......:         |:|.|:.|.         ..:.:....|....:
Mouse   600 MTSDKKSREKITAEHETTDDPSMLARVVKVEKQVQSIESKL---------DCLLDIYQQVLRKGS 655

  Fly   907 ATAVATAT--------NASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVA 963
            |:|:..|:        ..::...:...|:...|.....|......:.:.::||  |.::||.|.:
Mouse   656 ASALTLASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLTRSASANISRGL--QFILTPNEFS 718

  Fly   964 ELRRQVALENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLA 1028
            ..........:.:|     ...||:             ...|...|::  |::....|       
Mouse   719 AQTFYALSPTMHSQ-----ATQVPM-------------SQNDGSSVVA--TNNIANQI------- 756

  Fly  1029 AAGRQAGAYGLLSPLPAPLPPLHGPLLALPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTTTSTT 1093
                        |..|.|..|     ..|..||||......:...|.:|..:....|....|:..
Mouse   757 ------------SAAPKPAAP-----TTLQIPPPLSAIKHLSRPEPLLSNPTGLQESISDVTTCL 804

  Fly  1094 IA-----------LPLDVSLRY-----GATICS 1110
            :|           |..|.|||.     |.|:.|
Mouse   805 VASKESVQFAQSNLTKDRSLRKSFDMGGETLLS 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585
BTB_2 309..408 CDD:280393
Ion_trans 501..700 CDD:278921 61/210 (29%)
Ion_trans_2 613..696 CDD:285168 33/83 (40%)
Kcnq5NP_001153611.1 Ion_trans 161..359 CDD:278921 61/207 (29%)
Ion_trans_2 275..349 CDD:285168 31/74 (42%)
Selectivity filter. /evidence=ECO:0000250 312..317 3/4 (75%)
KCNQ_channel 473..660 CDD:281513 27/195 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..617 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 897..952
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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