Protein Alignment Shab and twk-1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001293466.1
• Gene: twk-1 / 192072
• WormBaseID: WBGene00006656
• Length: 451
• Species: Caenorhabditis elegans
• Alignment Length: 306
• Identity: 69/306 - (22%)
• Similarity: 124/306 - (40%)
• Gaps: 68/306 - (22%)

  Fly   389 LAFSD-DLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRD----EEEFGEGKCAEYQ 448
            :.|:| |.:..|.:|       :|......:.:.::.:|:..|...|.    .::|.:.||...:
 Worm     1 MTFNDGDNDRIGKEE-------EHAGLIENQIISQKTKKQLPSWLDRPYHVWRDQFQQDKCCPKK 58

  Fly   449 KYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAV--C 511
            ....||:      ||:        .::::..:||.|..|...|..|......|.:.:.::..  |
 Worm    59 MVKRELM------FAS--------TYVLILNVALILYVLFGCQVFDLRHSSTNNEASFLDRALFC 109

  Fly   512 ITWFTLEYILRFSASP--DKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQV 574
            ||  |:..|...:.:|  |:.|.    :.|:..:|.:|    ||.:....|:.
 Worm   110 IT--TISTIGYGNIAPFDDRGKV----ICILYCVAGIP----LFFMTVATNSV------------ 152

  Fly   575 FRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVS 639
             .::.|..|:..:..|..:::.||   ..|....||.....:|.||||...     |:.|  |:
 Worm   153 -LVVDICNIVHRSYSSQNVENSGF---RWYTSAILLAAHCFIGALIFSLWI-----DQLD--FL- 205

  Fly   640 IPETFWWAGITMTTVGYGDIYPTT--ALGKVIGTVCCICGVLVIAL 683
              :.|:::.|::||:||||..||.  ....:|.||....||..:.|
 Worm   206 --DAFYFSFISITTIGYGDYSPTPEGLFQYIIVTVYLCTGVATMLL 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	6/25 (24%)
		Ion_trans	464..700	CDD:459842	53/226 (23%)
twk-1	NP_001293466.1	Ion_trans_2	76..149	CDD:462301	20/82 (24%)
		Ion_trans_2	182..256	CDD:462301	26/78 (33%)