DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and kvs-2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001256236.1	Gene:	kvs-2 / 183120	WormBaseID:	WBGene00007862	Length:	575	Species:	Caenorhabditis elegans

Alignment Length:	528	Identity:	173/528 - (32%)
Similarity:	266/528 - (50%)	Gaps:	93/528 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 QSNTTGALQ-RTHSRSMSSIPPPEPFMIAQSKA----------VNSRVSINVGG----VRHEVL- 321
            |:....|:| .:..|.::..|||    |.:|::          .::.:.:||||    ||.|:.
Worm    68 QAEENAAVQAASMERRVAFRPPP----IGESRSTTITHDSGSNADTYMRLNVGGKSYYVRAELYT 128

  Fly   322 --WRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVD 384
              |        ||:..|.: ::||..:::.|.:.....||:.:|:.|....:::|:.||.||...
Worm   129 SEW--------TRMHELLD-SSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQ 184

  Fly   385 EMCVLAFSDDLEYWGVDELYLESCCQ--HKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKC-AE 446
            .:||..|.::||||.:....|.:|||  .::|.||       .....|..:.|.....:|.| |.
Worm   185 NVCVERFKEELEYWKIKPDQLSTCCQIPSEHHVRK-------LSRGTSFNEDDYVTDFDGACFAG 242

  Fly   447 YQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQ------------HI-----D 494
            .:..:|:.||.|.:|..|.|.|::|:.|:..|.:.|.|.::|:.|            |:     |
Worm   243 PRLAMWKFLEDPQSSVFAAVFALLSVFFVFASVVGLILGSMPEFQADSSNAATYHVMHVRSRPND 307

  Fly   495 NGT--------------------PQDNPQ--LAMVEAVCITWFTLEYILRFSASPDKWKFFKGGL 537
            .|.                    |.|:|.  |.::|.:||.|||.||::||:..|.|.:|.|..|
Worm   308 YGNKFGNDDDVAPNELLKDFVYKPTDSPNLPLTILEYICIGWFTFEYLVRFTIYPRKRQFVKKTL 372

  Fly   538 NIIDLLAILPYFVSLFL-LETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLR 601
            |||||..|||:::.:.| |...::...:|.....||:|.|::|:.|:.||||:||.||:.|.||:
Worm   373 NIIDLSTILPFYLEICLPLFGVESRLKEFTGAMLVVRVLRVLRMARVFKLARYSTSLQTFGHTLQ 437

  Fly   602 NSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALG 666
            :|..||.:|.:||..|::.||::.|:.||||..|.|.|||...||..:||.||||||..|.|.||
Worm   438 SSITELSMLSMFLITGIVFFSTIMYYLEKDEPHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLG 502

  Fly   667 KVIGTVCCICGVLVIALPIPIIVNNFA----------EFYKNQMR--REKALKRREALDRAKREG 719
            |::.|...|||::|:|.||.:||..||          :..:.||.  ...||.||....|..|..
Worm   503 KLVATSTSICGIIVLAFPISMIVEKFATAQQRAIEDQQIQQAQMSAVANNALLRRFPTRRKVRRN 567

  Fly   720 SIVSFHHI 727
            :.||.::|
Worm   568 TTVSVNNI 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	35/115 (30%)
		BTB_2	309..408	CDD:280393	31/105 (30%)
		Ion_trans	501..700	CDD:278921	91/211 (43%)
		Ion_trans_2	613..696	CDD:285168	42/92 (46%)
kvs-2	NP_001256236.1	BTB_POZ_Kv	111..199	CDD:349626	29/96 (30%)
kvs-2	NP_001256236.1	Ion_trans	329..535	CDD:366146	93/205 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I1679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920