Protein Alignment Shab and shw-1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001022089.1
• Gene: shw-1 / 174331
• WormBaseID: WBGene00008819
• Length: 619
• Species: Caenorhabditis elegans
• Alignment Length: 644
• Identity: 197/644 - (30%)
• Similarity: 308/644 - (47%)
• Gaps: 119/644 - (18%)

  Fly   222 AGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPT------HSQSNTTGAL 280
            |.|||...|....|.:|                    .|.|..:..||:      |....:..:.
 Worm    18 ASKEVVDTPIQTISSSH--------------------VSFQITTDPVPSMDYLSIHEDDTSMSSS 62

  Fly   281 QRTHSRSMSSIPPPEPFMIAQSKAVN------------SRVSINVGGVRHEVLWRTLERLPHTRL 333
            :||..|..|........:......||            .||.:||||:|||.....|:::|.|||
 Worm    63 ERTIERGFSRYGRKRSSVRMLLDEVNMTDRKTSWMDTEHRVILNVGGIRHETYSHVLKKIPATRL 127

  Fly   334 GRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYW 398
            .||   |.:.|      :|....|||||||||..||.|||:|||||||....:|...|.::||:|
 Worm   128 SRL---TPNLA------NYDPVLNEYFFDRHPGVFSMILNYYRTGKLHYPTNVCGPLFEEELEFW 183

  Fly   399 GVDELYLESCCQHKYHQRKEN-----VHEEMRKEAESLRQRD-------EEEFGEGKCAEYQKY- 450
            |:|...:|.||...|.|.::.     |.|.:..:.:...|.:       |:::..|..:::|:.
 Worm   184 GLDANQVEPCCWMTYTQHRDTQDTLAVIESLDLDGDPPTQEEIAKKFGWEDDYYTGNMSQWQRLK 248

  Fly   451 --LWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP--QLQHID------------NGTPQ 499
              :|.|.::|.:|..||||:|::|:|:::|.:...|.|.|  ::..||            ||...
 Worm   249 PRVWALFDEPWSSKYARVISVVNIIFVIISIVCFCLKTHPSFRIPDIDISTTMGNFSAPLNGVQM 313

  Fly   500 DN-----------PQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLF 553
            :|           |....||.:...||:.|::.|....|:...|.:..:|:||.:|.:.:::...
 Worm   314 NNIYVGKTATRAHPSFFYVELLSNIWFSGEFLTRMVFCPNVATFLRTPVNLIDFIATVSFYIDWA 378

  Fly   554 LLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGV 618
            |..|...:.      |..|:.|.|:||||:.||.:|||||:.|..|.:.|.:||.||:.|:.:|:
 Worm   379 LDRTLSGSN------RDSVEFFSIIRILRLFKLTQHSTGLKILIQTFKASAQELFLLVFFVLLGI 437

  Fly   619 LIFSSLAYFAEKDE--KDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVI 681
            :||::|.|:||:.|  ::.:|.|||...|||.||:.|:|:||:.|.|:||:::|:||.:.|||.|
 Worm   438 VIFAALVYYAERVEHNEENQFSSIPVGLWWAVITICTIGFGDLVPQTSLGRLVGSVCALMGVLTI 502

  Fly   682 ALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDT 746
            |||:|:||:|||.||.:...|.|..|:|.         .::..|.|......:.:..:|..:...
 Worm   503 ALPVPVIVSNFAMFYSHAQARSKLPKKRR---------RVLQPHEIKPVVGRSTTAVMISALTQR 558

  Fly   747 GKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN----LSQTDGNSTEGESTSGRNPATT 801
            |       |.....|.|:.|...    ||..:|    :...||::...:.:..:|..||
 Worm   559 G-------PVSGGGSNPSDGGPL----SAFSNNTPLLVCPPDGSTKPKKLSQNKNGGTT 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	51/119 (43%)
		Ion_trans	464..700	CDD:459842	97/262 (37%)
shw-1	NP_001022089.1	BTB_Shaw-like	100..211	CDD:349723	52/119 (44%)
		Ion_trans	264..521	CDD:459842	97/262 (37%)