DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcng3

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_596917.2	Gene:	Kcng3 / 171011	RGDID:	628832	Length:	433	Species:	Rattus norvegicus

Alignment Length:	423	Identity:	160/423 - (37%)
Similarity:	247/423 - (58%)	Gaps:	32/423 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILN 373
            |.:||||.|:.:....|:..|..|:.||..|.:...::|:||||....||||||||.::|..||.
  Rat    11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILL 75

  Fly   374 FYR-TGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEE 437
            :.| .|||.....||.|:|.:::.|||::..:||.|||.:...|..:.|  ....||.|.:....
  Rat    76 YVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTH--TFHAAEELGREQPR 138

  Fly   438 EFGEGKCAEYQKYLWEL---LEKPNTSFAARVIAVISILFIVLSTIALTLNTLP--QLQHIDNGT 497
            ..|. :.|..:::|..:   .|:|.:|.||:::|.:|::|:::|.:.|..:|||  :....||.:
  Rat   139 PTGP-EAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRAAAADNRS 202

  Fly   498 PQDNPQLA---------MVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVS-L 552
            ..|..:.:         ::||:||.|||.|.|:||..|.:|.:|.|..|||||||||.||::| |
  Rat   203 LDDRSRYSASPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVL 267

  Fly   553 FLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMG 617
            ..:.|.:|:  |.|.....::|.|:|||..::|||||..|||:||.||:..|:|:.:|::|:.:.
  Rat   268 MTVFTGENS--QLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVA 330

  Fly   618 VLIFSSLAYFAEK----DEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGV 678
            :.|||:|:...|.    :..:..|.|||...||..|:||||||||:||.|..|:::|.||.:.|:
  Rat   331 MAIFSALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGI 395

  Fly   679 LVIALPIPIIVNNFAEFYKNQMRREKALKRREA 711
            :::||||..|.::|.:.|..       ||.|.|
  Rat   396 VLLALPITFIYHSFVQCYHE-------LKFRSA 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	44/107 (41%)
		BTB_2	309..408	CDD:280393	41/99 (41%)
		Ion_trans	501..700	CDD:278921	88/212 (42%)
		Ion_trans_2	613..696	CDD:285168	35/86 (41%)
Kcng3	NP_596917.2	BTB	11..119	CDD:197585	44/107 (41%)
		BTB	11..111	CDD:295341	41/99 (41%)
		Ion_trans	216..417	CDD:278921	88/209 (42%)
		Ion_trans_2	<360..405	CDD:285168	23/44 (52%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920