DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and KCNV2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_598004.1	Gene:	KCNV2 / 169522	HGNCID:	19698	Length:	545	Species:	Homo sapiens

Alignment Length:	523	Identity:	183/523 - (34%)
Similarity:	285/523 - (54%)	Gaps:	50/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 PTHSIPTTSQQIVGSVGGVGVGGASSQSI----SGGVPTHSQSNTTG----------ALQRTHSR 286
            |.::......|...|:..:|....|..||    .|....:.:.:..|          |.:...:.
Human    15 PWNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDDLAEEDQQAG 79

  Fly   287 SMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDD 351
            .:::..|..|   :...|:.|.:::||||..:::.:..|...|.||||||...|:....:.||||
Human    80 EVTTAKPEGP---SDPPALLSTLNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDD 141

  Fly   352 YSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQR 416
            |....:||||||.|..|..:.|||.:|.|.::|.:|...|.::|.||||...|...||:..:.:|
Human   142 YEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEER 206

  Fly   417 KENVHEEMR-----------KEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVI 470
            ::.:.|.::           :|||.| .||...:|     ..::.||.|:|||.:|.||:.|.|.
Human   207 RDELSERLKIQHELRAQAQVEEAEEL-FRDMRFYG-----PQRRRLWNLMEKPFSSVAAKAIGVA 265

  Fly   471 SILFIVLSTIALTLNTLPQLQHID---NGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKF 532
            |..|:::|.:||.|||:.::|...   .|.|...|.|..||.:|:.:|||||:||.:::||..:|
Human   266 SSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRF 330

  Fly   533 FKGGLNIIDLLAILPYFVSLFLLE-------TNKNATDQFQDVRRVVQVFRIMRILRILKLARHS 590
            .:..||::||:||||.::.| |||       ...........|.:|::|.|:|||.|||||||||
Human   331 ARSALNLVDLVAILPLYLQL-LLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHS 394

  Fly   591 TGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVG 655
            |||::.|||||..|:::|.|:||:|||:..||:..|..|.|...|.|.:||.::|||.::::|||
Human   395 TGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVG 459

  Fly   656 YGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREA-----LDRA 715
            |||:||.|.||:....:|...|:::..:||.|:.|.|:::|......|....|||.     :.||
Human   460 YGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRA 524

  Fly   716 KRE 718
            :::
Human   525 RKK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	42/106 (40%)
		BTB_2	309..408	CDD:280393	40/98 (41%)
		Ion_trans	501..700	CDD:278921	90/205 (44%)
		Ion_trans_2	613..696	CDD:285168	34/82 (41%)
KCNV2	NP_598004.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..93		2/21 (10%)
		BTB	99..190	CDD:321966	37/90 (41%)
		Ion_trans	266..504	CDD:306908	101/238 (42%)
		Selectivity filter. /evidence=ECO:0000250	457..462		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920