Protein Alignment Shab and Kcns1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_032461.2
• Gene: Kcns1 / 16538
• MGIID: 1197019
• Length: 497
• Species: Mus musculus
• Alignment Length: 540
• Identity: 190/540 - (35%)
• Similarity: 294/540 - (54%)
• Gaps: 86/540 - (15%)

  Fly   298 MIAQSKAVNSRV---------SINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYS 353
            |:::.....|||         .:||||||..:..|.|.|.|.||||||:...:.|....|||||.
Mouse     1 MVSEFPGPGSRVPWRPRDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYD 65

  Fly   354 LADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQR-- 416
            .|.:|::|||||..|..:|:|||||.||::||:||.||..:.:|||:.|..|.:||:.:|.:|
Mouse    66 AAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRV 130

  Fly   417 -KENVHEEMRKEAESLR---------QRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVIS 471
             :....:|......|:.         ||:...:|..:|...::.||..:|.|..|..:::.:.:|
Mouse   131 ARPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVS 195

  Fly   472 ILFIVLSTIALTLNTLPQLQHIDNGTP-------------QDNPQLAMVEAVCITWFTLEYILRF 523
            |..::.|..|:.:::||:.|..:....             :|:|.|..:|..||.||:.|...|.
Mouse   196 IGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEEVRDDPVLRRLEYFCIAWFSFEVSSRL 260

  Fly   524 SASPDKWKFFKGGLNIIDLLAILPYFVSLF---LLETNKNAT-DQFQDVRRVVQVFRIMRILRIL 584
            ..:|....||...||:||::::||::::|.   .|...:.|: ::..|:.:||||||:|||.|:|
Mouse   261 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDQRGASGEELGDLGKVVQVFRLMRIFRVL 325

  Fly   585 KLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGI 649
            |||||||||:|||.||::||:|:|:|:|:||:||.:||.:||.||  |::..|.:||..:||..:
Mouse   326 KLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAE--EENEGFHTIPACWWWGTV 388

  Fly   650 TMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDR 714
            :||||||||:.|.|..||:..:.|.:.|:||:||||.||.|.|:.||    ||:|||
Mouse   389 SMTTVGYGDVVPETVGGKLAASGCILGGILVVALPITIIFNKFSHFY----RRQKAL-------- 441

  Fly   715 AKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779
               |.::.|......:|..:....:.||.::|.:.|:
Mouse   442 ---EAAVRSSGQREFEDLLSSVDGVSDVSLETSRDTS---------------------------- 475

  Fly   780 LSQTDGNSTEGESTSGRNPA 799
               .:|.||:.|:.:.|.||
Mouse   476 ---QEGRSTDLETQAPREPA 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	54/116 (47%)
		Ion_trans	464..700	CDD:459842	103/252 (41%)
Kcns1	NP_032461.2	BTB_POZ	21..126	CDD:453885	51/104 (49%)
		Ion_trans	188..439	CDD:459842	105/256 (41%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	392..397		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..497		11/60 (18%)