Protein Alignment Shab and Kcnq2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_017171224.1
• Gene: Kcnq2 / 16536
• MGIID: 1309503
• Length: 937
• Species: Mus musculus
• Alignment Length: 921
• Identity: 185/921 - (20%)
• Similarity: 331/921 - (35%)
• Gaps: 272/921 - (29%)

  Fly   448 QKYLWELLEKPNTSFAARVIAVI---SILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLAMVE 508
            |.:|:.:||:|      |..|.|   .:..:|.|.:.|:: :|:.:.:....|.      |.::|
Mouse    78 QNFLYNVLERP------RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGA------LYILE 130

  Fly   509 AVCITWFTLEYILRFSAS---------PDKWKFFKGGLNIIDLLAILPYFVSLFLL----ETNKN 560
            .|.|..|.:||.:|..|:         ..:.||.:....:||::.::   .|:.:|    :.|..
Mouse   131 IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLI---ASIAVLAAGSQGNVF 192

  Fly   561 ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGVL 619
            ||...:.:       |.::|||::::.|.....:.||..:....|||      |.|.|.||
Mouse   193 ATSALRSL-------RFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILA---- 246

  Fly   620 IFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALP 684
              |.|.|.|||.|.| .|.:..:..||..||:||:||||.||.|..|:::.....:.||...|||
Mouse   247 --SFLVYLAEKGEND-HFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALP 308

  Fly   685 IPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVS---FHHINLKDAFAKS---------- 736
            ..|:.:.||...:.|.|::...|||.     ...|.|.|   |:..||......|
Mouse   309 AGILGSGFALKVQEQHRQKHFEKRRN-----PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVT 368

  Fly   737 -------------------MDLIDVIVDTGKQTNVVHPKGKR-QSTPNIGRQTLD--VQSAPGHN 779
                               ::.::::.:...::.:...|..: :.:|:.||....  ....|||:
Mouse   369 VPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSKGRPCRGCLCGCCPGHS 433

  Fly   780 ----------LSQTDGNSTEGE-----STSGRNPAT------TGTGCYKNYDHVANLRNSNLHNR 823
                      .|...|.:.:|:     .|..|:|:.      :.:...|::......|.......
Mouse   434 SQKVSLKDRVFSSPRGMAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRTRQAFRI 498

  Fly   824 RGSSSEQD----AVPPYSF--DNPNAR------------QTSMMA------MESYRREQQAL--- 861
            :|::|.|:    ::|....  ||.:..            :.|:.|      :.|.|:.:::|
Mouse   499 KGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPY 563

  Fly   862 -----LQQQQ-------------QQQQQMLQMQQIQQKAPNGNGGA---TGGGVANNLAMVAASS 905
                 ::|..             |.:|:.|.:|...::.|.|...|   ...|:.:.:.|:....
Mouse   564 DVMDVIEQYSAGHLDMLSRIKSLQSRQEPLPVQSGHEQGPPGQNQAWHKGHQGLGDRIDMIVGPP 628

  Fly   906 AATAVATATNASNASNTAPGSEGAEGGGDGD---GGGVDDDNLSQAKG-----LP--IQMMITPG 960
            ..:........:... |||..|..:.....|   |.|....:..:.||     ||  ..||   |
Mouse   629 PPSTPRHKKYPTKGP-TAPSRESPQYSPRVDQIVGRGPTITDKDRTKGPAETELPEDPSMM---G 689

  Fly   961 EVAELRRQVA--------LENLQNQRMDNLEQDVPVEFECCF-----------CTTKDFKEFTDA 1006
            .:.::.:||.        |.::..|||.    ..|.|.|..|           .:.:|.::..|.
Mouse   690 RLGKVEKQVLSMEKKLDFLVSIYTQRMG----IPPAETEAYFGAKEPEPAPPYHSPEDSRDHADK 750

  Fly  1007 EGVISLPTSDFHKPICLEMRLAAAGRQAGAYGLLSP---LPAPLPPL-----------------H 1051
            .|.|              :::..:....|.....:|   .||..||.                 |
Mouse   751 HGCI--------------IKIVRSTSSTGQRNYAAPPAIPPAQCPPSTSWQQSHQRHGTSPVGDH 801

  Fly  1052 GPLLALPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTTTSTTIALPLDVSLRYGATICSSSNFNH 1116
            |.|:.:||||....:      |.|....:..|:.:.....|....|.:.:||...|..|..:.:|
Mouse   802 GSLVRIPPPPAHERS------LSAYGGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDH 860

  Fly  1117 -NYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDSSDTYASC--------QTHPFLSQG 1172
             ....:|:..::.                       .|.::.|...||        :..|::::|
Mouse   861 EELERSFSGFSIS-----------------------QSKENLDALGSCYAAVAPCAKVRPYIAEG 902

  Fly  1173 DLTADFNDEAC 1183
            :  :|.:.:.|
Mouse   903 E--SDTDSDLC 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	72/258 (28%)
Kcnq2	XP_017171224.1	Ion_trans	92..324	CDD:459842	71/254 (28%)
		KCNQ_channel	466..719	CDD:460954	44/260 (17%)
		KCNQ2_u3	733..821	CDD:465213	19/107 (18%)
		KCNQC3-Ank-G_bd	833..933	CDD:463411	16/104 (15%)