DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and Kcnk1

DIOPT Version :10

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_032456.2 Gene:Kcnk1 / 16525 MGIID:109322 Length:336 Species:Mus musculus


Alignment Length:366 Identity:76/366 - (20%)
Similarity:133/366 - (36%) Gaps:115/366 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   424 MRKEAESLRQRDEEEFGEGKC---AEYQKYLWELLEKPNTSFAARVIA---------VISILFI- 475
            :|:|...|::|..||.   :|   .:.:::|..:||..|  :...|::         ..|.||. 
Mouse    52 LRQELRKLKRRFLEEH---ECLSEPQLEQFLGRVLEASN--YGVSVLSNASGNWNWDFTSALFFA 111

  Fly   476 --VLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
              ||||.... :|:|.   .|.|           :|.||.:..:.                    
Mouse   112 STVLSTTGYG-HTVPL---SDGG-----------KAFCIIYSVIG-------------------- 141

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRI-----MRILRILKLARHSTGLQSLGF 598
                   :| |..|||....:..|  ....||.|..|.|     .:::.|:    |:.   .|||
Mouse   142 -------IP-FTLLFLTAVVQRVT--VHVTRRPVLYFHIRWGFSKQVVAIV----HAV---LLGF 189

  Fly   599 TLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTT 663
            .         .:..|..:...:||.|       |.|..|:   |:|::..|:::|:|.||..|..
Mouse   190 V---------TVSCFFFIPAAVFSVL-------EDDWNFL---ESFYFCFISLSTIGLGDYVPGE 235

  Fly   664 ALGK------VIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIV 722
            ...:      .||..|.:...|:..|   :::..|.|.::.:..|:....:::     |.|..:.
Mouse   236 GYNQKFRELYKIGITCYLLLGLIAML---VVLETFCELHELKKFRKMFYVKKD-----KDEDLVH 292

  Fly   723 SFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTP 763
            ...|..|  :|:...:.:..:.:..||:   .|....||.|
Mouse   293 IMEHDQL--SFSSVTEQVAGLKEEQKQS---EPFVASQSPP 328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720
Ion_trans 464..700 CDD:459842 53/258 (21%)
Kcnk1NP_032456.2 Ion_trans_2 <98..157 CDD:462301 19/101 (19%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:O00180 117..122 1/5 (20%)
Ion_trans_2 191..267 CDD:462301 20/88 (23%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:O00180 225..230 2/4 (50%)
Important for intracellular retention in recycling endosomes. /evidence=ECO:0000250|UniProtKB:O00180 293..299 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..336 6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

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