Protein Alignment Shab and Kcnc3

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_036008594.1
• Gene: Kcnc3 / 16504
• MGIID: 96669
• Length: 807
• Species: Mus musculus
• Alignment Length: 771
• Identity: 222/771 - (28%)
• Similarity: 301/771 - (39%)
• Gaps: 287/771 - (37%)

  Fly    32 VGQLQGGQAAGQQQQQQQATQQQQHSKQQQQQQQQQQQQLQLKQHQQQQQDILYQQHNEAIAIAR 96
            |...:|.|..|:||.|...|.|...|........||||
Mouse     7 VWSFRGRQGTGKQQPQPVPTPQPPESSPPPLPPPQQQQ--------------------------- 44

  Fly    97 GLQAATPADIGDNQPYYDTSGNVDWERAMGAGGAGAYGGIGIGSLPAAGGAAYHLGPANPAGLVS 161
                       .:||                                  |.|     |:|||
Mouse    45 -----------CSQP----------------------------------GTA-----ASPAG--- 56

  Fly   162 RHLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEV 226
            ..|..|.||..|.|..||||.|:|...|.|..:|
Mouse    57 APLSCGPGGRRAEPCPGLPAVAMGRHGGGGGDSG------------------------------- 90

  Fly   227 RYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSI 291
                                                                             
Mouse    91 ----------------------------------------------------------------- 90

  Fly   292 PPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLAD 356
                            ::.|||||||||....||..||.|||..|   |..||....  ||....
Mouse    91 ----------------KIVINVGGVRHETYRSTLRTLPGTRLAGL---TEPEAAARF--DYDPGT 134

  Fly   357 NEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVH 421
            :|:||||||..|:.:||:|||||||...::|...|.::|.:||:||..:|:||...|.|     |
Mouse   135 DEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQ-----H 194

  Fly   422 EEMRKEAESLRQRD-----------------EEEFGEG-------------KCAE---------- 446
            .:..:..:|....|                 ::|.|.|             .|.:
Mouse   195 RDAEEALDSFEAPDSSANANANAGGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPA 259

  Fly   447 -------------YQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDN--- 495
                         :|..:|.|.|.|.:|.|||.:|..|:.||::|.....|.|.....||.|
Mouse   260 GGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTV 324

  Fly   496 -------GTPQDN---------PQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLA 544
                   |.|.:|         |.|..||.||:.|||.|:::|.:..|||.:|.|..|||||.:|
Mouse   325 TQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVA 389

  Fly   545 ILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGL 609
            |||:::.:.|...:..|.   :||...::|.|.:|||||.||.||..||:.||.|||.|..|..|
Mouse   390 ILPFYLEVGLSGLSSKAA---KDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLL 451

  Fly   610 LMLFLAMGVLIFSSLAYFAEK---DEKD------TKFVSIPETFWWAGITMTTVGYGDIYPTTAL 665
            |::|||:|||||:::.|:||:   |..|      |.|.:||..||||.:||||:||||:||.|..
Mouse   452 LIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWS 516

  Fly   666 GKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR-EALDRAKREGS 720
            |.::|.:|.:.|||.||:|:|:|||||..:|...|.::|..|:: :.:.|..:.||
Mouse   517 GMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGS 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	49/107 (46%)
		Ion_trans	464..700	CDD:459842	114/263 (43%)
Kcnc3	XP_036008594.1	BTB_KCNC1_3	91..204	CDD:349721	52/122 (43%)
		Ion_trans	290..551	CDD:459842	114/263 (43%)