DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and Kcnc1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_006540709.1	Gene:	Kcnc1 / 16502	MGIID:	96667	Length:	594	Species:	Mus musculus

Alignment Length:	493	Identity:	176/493 - (35%)
Similarity:	256/493 - (51%)	Gaps:	80/493 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 NSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSS 370
            :.|:.|||||.||:....||..||.|||..|.|...|...     ||....:|:||||||..|:.
Mouse     7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAH 66

  Fly   371 ILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESL---- 431
            |||:|||||||...::|...:.::|.:||:||..:|.||...|.|     |.:..:..:|.
Mouse    67 ILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQ-----HRDAEEALDSFGGAP 126

  Fly   432 ---RQRDEEEFGEGKCAE---------------------------YQKYLWELLEKPNTSFAARV 466
               ...|.:..|.|...:                           :|..:|.|.|.|.:|..||.
Mouse   127 LDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARY 191

  Fly   467 IAVISILFIVLSTIALTLNT---------LPQLQHIDNGT-------PQDNPQLAMVEAVCITWF 515
            :|..|:.||::|.....|.|         ..:::::.|||       .:....|..:|.||:.||
Mouse   192 VAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWF 256

  Fly   516 TLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRI 580
            |.|:::|....|:|.:|.|..|||||.:||||:::.:.|...:..|.   :||...::|.|.:||
Mouse   257 TFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAA---KDVLGFLRVVRFVRI 318

  Fly   581 LRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEK---------DEKDTK 636
            |||.||.||..||:.||.|||.|..|..||::|||:|||||:::.|:||:         ..:.|.
Mouse   319 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTH 383

  Fly   637 FVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMR 701
            |.:||..||||.:||||:||||:||.|..|.::|.:|.:.|||.||:|:|:|||||..:|...|.
Mouse   384 FKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMA 448

  Fly   702 REK-ALKRREALDRAKREGS-------IVSFHHINLKD 731
            ::| ..|:::.:.|..:.||       :.|.||....|
Mouse   449 KQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSD 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	47/106 (44%)
		BTB_2	309..408	CDD:280393	44/98 (45%)
		Ion_trans	501..700	CDD:278921	94/207 (45%)
		Ion_trans_2	613..696	CDD:285168	45/91 (49%)
Kcnc1	XP_006540709.1	BTB_KCNC1_3	6..122	CDD:349721	50/124 (40%)
Kcnc1	XP_006540709.1	Ion_trans	189..447	CDD:366146	106/260 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820