DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcnb1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_032446.2	Gene:	Kcnb1 / 16500	MGIID:	96666	Length:	857	Species:	Mus musculus

Alignment Length:	1004	Identity:	434/1004 - (43%)
Similarity:	561/1004 - (55%)	Gaps:	209/1004 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 SRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELC 349
            |||.||: ||||..|.:|||.:.||.:||||:.||||||||:|||.||||:||:|.||::::::|
Mouse    10 SRSTSSL-PPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLQVC 73

  Fly   350 DDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYH 414
            |||||.||||||||||.:|:|||||||||:||:::|||.|:||.:|:|||:||:|||||||.:||
Mouse    74 DDYSLEDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYH 138

  Fly   415 QRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLST 479
            |:||.::||:::|||:||:|:.|||....|||.:|.||:||||||:|.||:::|:|||:||||||
Mouse   139 QKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLST 203

  Fly   480 IALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLL 543
            |||:|||||:||.:|. |...||||||.||||||.|||:||:|||.:||.|||||||.||.||||
Mouse   204 IALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLL 268

  Fly   544 AILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELG 608
            |||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.||.|||
Mouse   269 AILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELG 332

  Fly   609 LLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVC 673
            ||:||||||::|||||.:||||||.||||.|||.:||||.|||||||||||||.|.|||::|.:|
Mouse   333 LLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLC 397

  Fly   674 CICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMD 738
            ||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :|:|||||:|::
Mouse   398 CIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNMKDAFARSIE 459

  Fly   739 LIDVIVDTGKQTNVVHPKGKRQS---TPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRNPAT 800
            ::|::|:  |....|..|.|.|.   :||..:.|....|                |::|.::..|
Mouse   460 MMDIVVE--KNGEGVAKKDKVQDNHLSPNKWKWTKRALS----------------ETSSSKSFET 506

  Fly   801 TGTGCYKNYDHVANLRNSNLHNRRGSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALL--- 862
            ...|              :....|.|||.|         :.|.:|...|..:..:.:.|.:|
Mouse   507 KEQG--------------SPEKARSSSSPQ---------HLNVQQLQDMYSKMAKTQSQPILNTK 548

  Fly   863 ----QQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATATNASNAS--- 920
                |.|.|::.:|..|.......|....|.        :.|.:.||..:.::.||:...|:
Mouse   549 EMAPQSQPQEELEMGSMPSPVAPLPTRTEGV--------IDMRSMSSIDSFISCATDFPEATRFS 605

  Fly   921 -------------NTAP--GSEGAEGGGDGDGGGVDDDNLSQAKGLPIQMMITPGEVAELRRQVA 970
                         :|||  |..||.|   ..||.:.:.|       ||......|...|..|
Mouse   606 HSPLASLSGKSGGSTAPEVGWRGALG---ASGGRLMETN-------PIPEASRSGFFVESPR--- 657

  Fly   971 LENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSD-FHKPICLEMRLAAAGRQA 1034
                     .:::...|::......      .|.:.:....||... :|.|  |..|..||...|
Mouse   658 ---------SSMKTHNPMKLRALKV------NFLEGDPTPLLPALGLYHDP--LRNRGGAAAAVA 705

  Fly  1035 GAYGLLSPLPAPLPPLHGPLLALPPPPPLPPTSCAAVL-LPAISQSSSTSSSYGTTT-------S 1091
            |                              ..||::| .|.:|..||..::....|       .
Mouse   706 G------------------------------LECASLLDKPVLSPESSIYTTASARTPPRSPEKH 740

  Fly  1092 TTIALPLDVSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDS 1156
            |.||.                ||....:...:|.|   ...|.||:               ||||
Mouse   741 TAIAF----------------NFEAGVHQYIDTDT---DDEGQLLY---------------SVDS 771

  Fly  1157 S---DTYASCQTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGISSSTGFIVGLPST 1218
            |   ..:.|  |.|..|.|..|...:.|:..|......|..|.:...:            |||..
Mouse   772 SPPKSLHGS--TSPKFSLGARTEKNHFESSPLPTSPKFLRPNCVYASE------------GLPGK 822

  Fly  1219 NSSGGPRAQVKKSASGDTA--LRNLAAGG 1245
                ||.||.|......|:  :..|..||
Mouse   823 ----GPGAQEKCKLENHTSPDVHMLPGGG 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	74/106 (70%)
		BTB_2	309..408	CDD:280393	68/98 (69%)
		Ion_trans	501..700	CDD:278921	157/198 (79%)
		Ion_trans_2	613..696	CDD:285168	65/82 (79%)
Kcnb1	NP_032446.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		8/11 (73%)
		BTB_POZ_KCNB2	15..141	CDD:349719	85/126 (67%)
		Self-association. /evidence=ECO:0000250\|UniProtKB:P15387	59..75		6/15 (40%)
		Ion_trans	188..424	CDD:366146	181/236 (77%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000250\|UniProtKB:P15387	448..481		14/34 (41%)
		Kv2channel	467..678	CDD:367541	53/285 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..569		26/132 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..627		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..802		12/35 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..857		12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I944
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I737
Isobase	1	0.950	-	0	Normalized mean entropy	S4489
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002877
OrthoInspector	1	1.000	-	-		otm44008
orthoMCL	1	0.900	-	-		OOG6_101602
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3999
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.840