DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcna7

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_034726.2	Gene:	Kcna7 / 16495	MGIID:	96664	Length:	489	Species:	Mus musculus

Alignment Length:	494	Identity:	177/494 - (35%)
Similarity:	248/494 - (50%)	Gaps:	106/494 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 GVGGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHE 319
            ||..||.        .|.:|....|::....|    .|||        .....|:.:||.|:|.|
Mouse    13 GVAAASG--------PHVRSPVARAVRAMEPR----CPPP--------CGCCERLVLNVAGLRFE 57

  Fly   320 VLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GK 379
            ...|||.|.|.|.||    |.|             .|..|..|||||||..||.::|.:|:: |:
Mouse    58 TRARTLGRFPDTLLGDPVRRSR-------------FYDGARREYFFDRHRPSFDAVLYYYQSGGR 109

  Fly   380 LHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKC 444
            |.....:.:..|.:::.::|:.                          |.:|.:..|:|    .|
Mouse   110 LRRPAHVPLDVFLEEVSFYGLG--------------------------AAALARLREDE----GC 144

  Fly   445 A----------EYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQ---------- 489
            |          .:.:.||.|.|.|.:|.||||:||:|:|.|::|.:...|.|||.
Mouse   145 AVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPDFRDDRDDPGL 209

  Fly   490 ----------LQHIDNGTPQD--------NPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGG 536
                      |..::..:|..        |....:||.:||.||:.|.::|..|.|.|..|||..
Mouse   210 APVAAATGPFLARLNGSSPMPGAPPRQPFNDPFFVVETLCICWFSFELLVRLVACPSKAVFFKNV 274

  Fly   537 LNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLR 601
            :|:||.:|||||||:|......:....|......:::|.|::|:.||.||:|||.|||.||.|||
Mouse   275 MNLIDFVAILPYFVALGTELARQRGVGQPAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLR 339

  Fly   602 NSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALG 666
            .|.:|||||:.||.:||::|||..||||.|..||.|.||||:||||.:|||||||||:.|.|..|
Mouse   340 ASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDTHFTSIPESFWWAVVTMTTVGYGDMAPVTVGG 404

  Fly   667 KVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKA 705
            |::|::|.|.|||.|:||:|:||:||:.||..:...|:|
Mouse   405 KIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEA 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	32/111 (29%)
		BTB_2	309..408	CDD:280393	32/103 (31%)
		Ion_trans	501..700	CDD:278921	103/198 (52%)
		Ion_trans_2	613..696	CDD:285168	50/82 (61%)
Kcna7	NP_034726.2	BTB_2	47..137	CDD:280393	34/128 (27%)
		BTB	47..130	CDD:197585	31/95 (33%)
		Ion_trans	228..437	CDD:278921	104/208 (50%)
		Ion_trans_2	352..431	CDD:285168	48/78 (62%)
		Selectivity filter. /evidence=ECO:0000250	391..396		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820