DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shab and Kcna5

DIOPT Version :10

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_666095.1 Gene:Kcna5 / 16493 MGIID:96662 Length:602 Species:Mus musculus


Alignment Length:608 Identity:196/608 - (32%)
Similarity:288/608 - (47%) Gaps:150/608 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 GGVGVGGASSQSISG--GVP----THSQSNTTGALQR-TH-SRSMSSIP-PPEPFMIAQSKAVNS 307
            ||...|.:..||..|  |.|    .::||..|...:| || .......| ||.|..:.|.:..::
Mouse    18 GGGEAGASCVQSPRGECGCPPTAGLNNQSKETSPRRRATHEDAGQGGRPLPPMPQELPQPRRPSA 82

  Fly   308 -----------------------------RVSINVGGVRHEVLWRTLERLPHTRLG----RLREC 339
                                         ||.||:.|:|.|....||.:.|:|.||    |||. 
Mouse    83 EDEEGEGDPGLGTVEEDQAPQDSGSLHHQRVLINISGLRFETQLGTLAQFPNTLLGDPVKRLRY- 146

  Fly   340 TTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDEL 403
                        :....|||||||:..||..||.:|:: |:|.....:.:..|:|::        
Mouse   147 ------------FDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEI-------- 191

  Fly   404 YLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIA 468
                    :::|..:...|..| |.|...:.:|:.....   |:|:.:|.:.|.|.:|.:||.||
Mouse   192 --------RFYQLGDEAMERFR-EDEGFIKEEEKPLPRN---EFQRQVWLIFEYPESSGSARAIA 244

  Fly   469 VISILFIVLSTIALTLNTLPQ-------LQH----------------IDNGTPQDNPQLA----- 505
            ::|:|.|::|.|...|.|||:       |:|                ..:|.....|.:|     
Mouse   245 IVSVLVILISIITFCLETLPEFRDERELLRHPPVPPQPPAPAPGANGSGSGVLSSGPTVAPLLPR 309

  Fly   506 -------MVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATD 563
                   :||..|:.|||.|.::||.|.|.|.:|.:..:||||::||.|||::|......:....
Mouse   310 TLADPFFIVETTCVIWFTFELLVRFFACPSKAEFSRNIMNIIDIVAIFPYFITLGTELAEQQPGG 374

  Fly   564 QFQDVRR-----VVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS 623
            ..|:.::     :::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||.:||::|||
Mouse   375 GGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSS 439

  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688
            ..||||.|.:.:.|.|||:.||||.:|||||||||:.|.|..||::|::|.|.|||.||||:|:|
Mouse   440 AVYFAEADNQGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVI 504

  Fly   689 VNNFAEFYKNQMRREK--ALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTN 751
            |:||..||..:...|:  |||..:.:.|  ||..:                       |||.|..
Mouse   505 VSNFNYFYHRETDHEEQAALKEEQGIQR--RESGL-----------------------DTGGQRK 544

  Fly   752 VVHPK-------GKRQSTPNIGR 767
            |...|       |..:||.:|.|
Mouse   545 VSCSKASFCKTGGPLESTDSIRR 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720 32/141 (23%)
Ion_trans 464..700 CDD:459842 115/275 (42%)
Kcna5NP_666095.1 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P22460 1..202 52/212 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..107 19/88 (22%)
BTB_POZ 111..237 CDD:453885 43/158 (27%)
Ion_trans 240..515 CDD:459842 115/274 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..297 2/22 (9%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 407..420 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 469..474 4/4 (100%)
PDZ-binding 600..602
Blue background indicates that the domain is not in the aligned region.

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