DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shab and Kcna4

DIOPT Version :10

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_067250.2 Gene:Kcna4 / 16492 MGIID:96661 Length:654 Species:Mus musculus


Alignment Length:635 Identity:195/635 - (30%)
Similarity:285/635 - (44%) Gaps:167/635 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 HLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEVR 227
            |:.||.............|.:..:.|.|.|.|.|:|.|:|             |||.|       
Mouse    16 HMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTG-------------GSGGG------- 60

  Fly   228 YAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSM---- 288
                    |.|...|.             |..||..     |..|:.:.....|||..:.:    
Mouse    61 --------PHHHHQTR-------------GAYSSHD-----PQGSRGSRRRRRQRTEKKKLHHRQ 99

  Fly   289 SSIPPPEPFMIAQSK-------------------------------------------------- 303
            ||.|.....|.:.|:                                                  
Mouse   100 SSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGG 164

  Fly   304 ----AVN-----SRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEY 359
                :|.     .||.|||.|:|.|...:||.:.|.|.||...:.|.:         :....|||
Mouse   165 GGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQY---------FDPLRNEY 220

  Fly   360 FFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEE 423
            ||||:..||.:||.:|:: |:|.....:....|::::                |::|..|....:
Mouse   221 FFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEV----------------KFYQLGEEALLK 269

  Fly   424 MRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP 488
            .|::...:|:.::....|.   |::|.:|.|.|.|.:|..||.||::|:|.|::|.:...|.|||
Mouse   270 FREDEGFVREEEDRALPEN---EFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLP 331

  Fly   489 QLQ------------------------HIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPD 528
            :.:                        |::| |....|....:||.|||.||:.|:::|..|.|.
Mouse   332 EFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPS 396

  Fly   529 KWKFFKGGLNIIDLLAILPYFVSL--FLLETNKNATDQFQDVR--RVVQVFRIMRILRILKLARH 589
            :..|||..:||||:::|||||::|  .|.:.......|.|...  .::::.|::|:.||.||:||
Mouse   397 QALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRH 461

  Fly   590 STGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTV 654
            |.|||.||.|||.|.:|||||:.||.:||::|||..||||.||..|.|.|||:.||||.:|||||
Mouse   462 SKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTV 526

  Fly   655 GYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK 704
            ||||:.|.|..||::|::|.|.|||.||||:|:||:||..||..:...|:
Mouse   527 GYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEE 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720 31/113 (27%)
Ion_trans 464..700 CDD:459842 118/264 (45%)
Kcna4NP_067250.2 K_channel_TID 1..>37 CDD:429748 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..145 29/166 (17%)
BTB_POZ 177..304 CDD:453885 42/154 (27%)
Ion_trans 307..571 CDD:459842 118/263 (45%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 463..476 8/12 (67%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 525..530 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..654
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385 652..654
Blue background indicates that the domain is not in the aligned region.

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