DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and Kcna2

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_032443.3 Gene:Kcna2 / 16490 MGIID:96659 Length:499 Species:Mus musculus


Alignment Length:481 Identity:175/481 - (36%)
Similarity:262/481 - (54%) Gaps:90/481 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 RVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPKSF 368
            ||.||:.|:|.|...:||.:.|.|.||    |:|.             :....|||||||:..||
Mouse    34 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRY-------------FDPLRNEYFFDRNRPSF 85

  Fly   369 SSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLR 432
            .:||.:|:: |:|.....:.:..||:::.::.:.|..:                 ||.:|.|...
Mouse    86 DAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAM-----------------EMFREDEGYI 133

  Fly   433 QRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP----QLQHI 493
            :.:|....|.   |:|:.:|.|.|.|.:|..||:||::|::.|::|.::..|.|||    :.:.:
Mouse   134 KEEERPLPEN---EFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDM 195

  Fly   494 DNG-----------------TPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIID 541
            ..|                 |...:| ..:||.:||.||:.|:::||.|.|.|..||...:||||
Mouse   196 HGGGVTFHTYSNSTIGYQQSTSFTDP-FFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIID 259

  Fly   542 LLAILPYFVSL--FLLETNKNATDQFQDVR-RVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            ::||:|||::|  .|.|..::|....|.:. .:::|.|::|:.||.||:|||.|||.||.||:.|
Mouse   260 IVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKAS 324

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            .:|||||:.||.:||::|||..||||.||:|::|.|||:.||||.::||||||||:.|||..||:
Mouse   325 MRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKI 389

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKAL------------------KRREALDRA 715
            :|::|.|.|||.||||:|:||:||..||..:...|:..                  |.|.|...:
Mouse   390 VGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTIS 454

  Fly   716 K------REG---SIVSFHHINLKDA 732
            |      :||   |...|...|||.|
Mouse   455 KSDYMEIQEGVNNSNEDFREENLKTA 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585 31/111 (28%)
BTB_2 309..408 CDD:280393 31/103 (30%)
Ion_trans 501..700 CDD:278921 104/201 (52%)
Ion_trans_2 613..696 CDD:285168 50/82 (61%)
Kcna2NP_032443.3 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142 1..125 32/120 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
BTB_POZ 33..159 CDD:365784 44/157 (28%)
Ion_trans 162..420 CDD:395416 117/258 (45%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 312..325 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142 497..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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