DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and Kcna1

DIOPT Version :10

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_034725.3 Gene:Kcna1 / 16485 MGIID:96654 Length:495 Species:Mus musculus


Alignment Length:474 Identity:170/474 - (35%)
Similarity:260/474 - (54%) Gaps:72/474 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 RVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSIL 372
            ||.||:.|:|.|...:||.:.|:|.||..::...:         :....|||||||:..||.:||
Mouse    38 RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRY---------FDPLRNEYFFDRNRPSFDAIL 93

  Fly   373 NFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDE 436
            .:|:: |:|.....:.:..||::::::.:.|..:|     |:.:.:..:.||.|...|.      
Mouse    94 YYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME-----KFREDEGFIKEEERPLPEK------ 147

  Fly   437 EEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQ---------- 491
                     |||:.:|.|.|.|.:|..|||||::|::.|::|.:...|.|||:|:          
Mouse   148 ---------EYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIH 203

  Fly   492 HIDNGTPQDNPQL-----AMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVS 551
            .|||.|......:     .:||.:||.||:.|.::||.|.|.|..|||..:|.||::||:|||::
Mouse   204 RIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFIT 268

  Fly   552 L--FLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFL 614
            |  .:.|...|...:......:::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||
Mouse   269 LGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFL 333

  Fly   615 AMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVL 679
            .:||::|||..||||.:|.::.|.|||:.||||.::||||||||:||.|..||::|::|.|.|||
Mouse   334 FIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVL 398

  Fly   680 VIALPIPIIVNNFAEFYKNQMRREKA----------------LKRREALDRAKRE---------G 719
            .||||:|:||:||..||..:...|:.                |.||.:...:|.|         .
Mouse   399 TIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNN 463

  Fly   720 SIVSFHHINLKDAFAKSMD 738
            ||..:...|::.....:.|
Mouse   464 SIAHYRQANIRTGNCTTAD 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720 32/106 (30%)
Ion_trans 464..700 CDD:459842 116/252 (46%)
Kcna1NP_034725.3 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 30/98 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
BTB_POZ 37..163 CDD:453885 43/153 (28%)
Ion_trans 166..418 CDD:459842 116/251 (46%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495
Blue background indicates that the domain is not in the aligned region.

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