Protein Alignment Shab and Shab

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_061508664.1
• Gene: Shab / 1276592
• VectorBaseID: AGAMI1_012264
• Length: 1355
• Species: Anopheles gambiae
• Alignment Length: 1621
• Identity: 859/1621 - (52%)
• Similarity: 973/1621 - (60%)
• Gaps: 397/1621 - (24%)

  Fly     1 MVGERDRDREAVRWATGESTPLQTNNGVLQMVGQLQGGQAAGQQQQQQQATQQQQHSKQQQQQQQ 65
            |||:|||:||||||..||:||...|||   ..|.:.||
Mosquito     8 MVGDRDREREAVRWELGETTPPPFNNG---GPGSMCGG--------------------------- 42

  Fly    66 QQQQQLQLKQHQQQQQDILYQQHNEAIAIARGLQAATPADIGDNQPYYDTSGNVDWERAMGA--G 128
                                              .|.|                    |:||  |
Mosquito    43 ----------------------------------TALP--------------------ALGAIGG 53

  Fly   129 GAGAY-GGIGIGSLPAAGGAAYHLGPANPAGLVSRHLDYGDGGHLAGPSAGLPAGAVGSGAGAGA 192
            ||||. |....|:.|..  |:..:||....|          ||   |.:.||.|.:|     .||
Mosquito    54 GAGALPGSFDDGNAPTT--ASSIIGPLASVG----------GG---GSTTGLSALSV-----TGA 98

  Fly   193 GAGASVTGSGSGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVG 257
            |...|::|||.|..:|.|.|||.|.|...:||||||||||:.||||           ....:..|
Mosquito    99 GPAGSLSGSGPGGASGVGGGAGGGGGGAGSGKEVRYAPFPIQSPTH-----------QAAAMAAG 152

  Fly   258 GASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLW 322
            .|::       |.::|. ....|||.|||||||| |||||||.:|||:|.||.||||||:|||||
Mosquito   153 NATN-------PNYAQM-AQAPLQRAHSRSMSSI-PPEPFMIMRSKALNRRVLINVGGVKHEVLW 208

  Fly   323 RTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMC 387
            |||||||||||||||||.|||||.||||||||.||||||||||||||||||||||||||:|||||
Mosquito   209 RTLERLPHTRLGRLRECNTHEAISELCDDYSLIDNEYFFDRHPKSFSSILNFYRTGKLHLVDEMC 273

  Fly   388 VLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLW 452
            |||||||||||||||||||||||||||||||:|||||||||||||||:|||||:||||:||||||
Mosquito   274 VLAFSDDLEYWGVDELYLESCCQHKYHQRKEHVHEEMRKEAESLRQREEEEFGDGKCAQYQKYLW 338

  Fly   453 ELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTL 517
            ||||||||||||||||||||||||||||||||||||.||...|||.||||:||||||||||||||
Mosquito   339 ELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPSLQSDHNGTSQDNPELAMVEAVCITWFTL 403

  Fly   518 EYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILR 582
            ||:||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mosquito   404 EYVLRFSASPDKWKFFKGGLNIIDLFAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILR 468

  Fly   583 ILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWA 647
            ||||||||||||||||||||||||||||||||||||||||||||||||||..|||:|||||||||
Mosquito   469 ILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEPQTKFISIPETFWWA 533

  Fly   648 GITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREAL 712
            ||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   534 GITMTTVGYGDIYPTTPLGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREAL 598

  Fly   713 DRAKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPG 777
            |||||||||||||||||:||||||||||||||||                              |
Mosquito   599 DRAKREGSIVSFHHINLRDAFAKSMDLIDVIVDT------------------------------G 633

  Fly   778 HNLSQTDGNST-EGESTS-GRNPATTGTGCYKNYDHVA------NLRNSNLHNR----------R 824
            ||:|..||||| ||:|.| |||||.||.||||||.|.|      |.::|::...          .
Mosquito   634 HNMSVADGNSTEEGDSVSGGRNPAMTGVGCYKNYKHSAGPRKRVNSQDSSVFQHAQNESFAQPMM 698

  Fly   825 GSSSEQDAVPPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGA 889
            |:|.:.:|.||||   |:.:..||.|.:....|:|.|:.|:..|.:..:.|
Mosquito   699 GASLDTEAAPPYS---PSMQHHSMAANDMDAGEEQQLIMQETPQHEPPVMM-------------- 746

  Fly   890 TGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQ 954
                                 ||....:|
Mosquito   747 ---------------------ATRAYYNN------------------------------------ 754

  Fly   955 MMITPGEVAELRRQVALENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHK 1019
             ..:..||.|||||||||.....:.|..:.::|.||||||||:|::|||.||||::.|||||||.
Mosquito   755 -QWSHEEVEELRRQVALETSSTSKRDKSDTELPSEFECCFCTSKEYKEFIDAEGLMPLPTSDFHT 818

  Fly  1020 PICLEMRL---------AAAGRQAGAYGLLSPLPAPLPPLHGPLLALPPPPPLPPTSCAAVLLPA 1075
            .:|:|||:         .|...|.|...:..|.|....|:..|          .||:.|.   .|
Mosquito   819 TVCMEMRMLRNSMNNNCIATANQFGPSTISYPYPYMDTPIKHP----------APTNGAN---GA 870

  Fly  1076 ISQSSSTSSSYGTTTSTTIALPLDVSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGN 1140
            ||..||...:..                 |||                    ||||.||.:
Mosquito   871 ISNGSSGGGAAA-----------------GAT--------------------GGGGGGTFI---- 894

  Fly  1141 YNGSNNNNADLASVDSSDTYASCQTHPFLSQGDLTADFNDEACALD-IDMDNLYINPLERE---- 1200
              .||:||.||||||||||||||||||||||.|||:|..|....|| :|.:||||||||::
Mosquito   895 --NSNSNNGDLASVDSSDTYASCQTHPFLSQADLTSDIVDMPFDLDTLDTNNLYINPLEKDSQQK 957

  Fly  1201 --------QHQGISSSTGFIVGLPSTNSSGGPRAQVKKSASGDTALRNLAAGGVGAGGLSPLNDV 1257
                    .||.:......:|.:    ..|.||:|||||||||||||:|        |.||::|.
Mosquito   958 QQQQQQQHHHQLLMLQQRPMVAM----GVGVPRSQVKKSASGDTALRSL--------GASPMDDE 1010

  Fly  1258 YQS-----FDVQERGSRVSLNENSVPKHRKTRFQQSFTAMRPSGATGVLG----SSVLGGMRPRA 1313
            |:.     ||..:|||.|||||..||||||||||||      ||:| ||.    ||.|...||:.
Mosquito  1011 YRQFQGSPFDAADRGSHVSLNETPVPKHRKTRFQQS------SGST-VLAAATTSSALSVARPKT 1068

  Fly  1314 RFEDTKLDDETGGRREGELAGGSGSPAASGSGGLSGQGPKKKRSVFMPGKSLATATKLINQHLFG 1378
            |||:.|...|:     .|.|..:|:.|.:.|...:| ..|.:||.|||.||||:|||||||||||
Mosquito  1069 RFENLKSSIES-----LEDAAATGAAATTSSTTTAG-SKKTRRSSFMPAKSLASATKLINQHLFG 1127

  Fly  1379 IQN-----VGAKAKFESKHSSSIDSIDASPNLEHHRRSKSILKNKSDISRVLSDPESERLLADNM 1438
            |.|     .||..|..   |.||||::.||.||.||||||||||||:.||:||||||||||||||
Mosquito  1128 IPNSTPKDAGADTKLS---SISIDSLETSPQLETHRRSKSILKNKSEASRLLSDPESERLLADNM 1189

  Fly  1439 SGSGVSDNGTVMG-ESGSDYSPNKLPHSVLAKSISPPPLRHRTLMHQRSGPATL--QSKP---TK 1497
            |||||||||..|| :|.:|||.:    :::|.||:|...||| |.||||.||:|  .:||   :|
Mosquito  1190 SGSGVSDNGANMGSDSNTDYSGS----TMIATSITPLVQRHR-LTHQRSTPASLGATAKPLAASK 1249

  Fly  1498 FQTPRYPEEQALRQVKPLLSRG----------TPSTSASAGSADGQQTRDSSLDSETTFTS 1548
            |..|||.:|:..||.||.|:||          |.......|      ||:||.:|||.|::
Mosquito  1250 FSLPRYSQEEVTRQTKPQLTRGVGIGTYVDHLTGDRRLDTG------TRESSTESETAFST 1304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	100/107 (93%)
		Ion_trans	464..700	CDD:459842	223/235 (95%)
Shab	XP_061508664.1	None