Protein Alignment Shab and CATSPER1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_444282.3
• Gene: CATSPER1 / 117144
• HGNCID: 17116
• Length: 780
• Species: Homo sapiens
• Alignment Length: 859
• Identity: 147/859 - (17%)
• Similarity: 270/859 - (31%)
• Gaps: 329/859 - (38%)

  Fly    85 YQQHNEAIAIARGLQAATPADIGDNQPYYD--TSGNV--DWERAMGAGGAGAYGGIGIGSLPAAG 145
            |:.|:..:...||.....|    :.|.::|  .|.:|  ....:.......|:|..|.|..|:.|
Human    43 YELHHHGVPHQRGESHHPP----EFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQG 103

  Fly   146 GAAYHLGPANPAGLVSRHLDYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVTGSGSGAGTGTG 210
            .             |..|..||:..|                        ..:...|.....|:
Human   104 A-------------VPSHRSYGEDYH------------------------DELQRDGRRHHDGS- 130

  Fly   211 TGAGSGSGSGAAGKEVRYAPFPVASPTH----SIPTTSQQIVGSVGGVGVGGASSQSISGGVPTH 271
                            :|..|...|.:|    |.....|.:          |.:....|.|||.|
Human   131 ----------------QYGGFHQQSDSHYHRGSHHGRPQYL----------GENLSHYSSGVPHH 169

  Fly   272 SQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHT----- 331
            .:::..|.....|.        |.|:    |::.:...:.::.|::|:....  .::||.
Human   170 GEASHHGGSYLPHG--------PNPY----SESFHHSEASHLSGLQHDESQH--HQVPHRGWPHH 220

  Fly   332 ----RLGRLRECTTHE----------------------AIVELCDDYSLAD---NEYFFDRHPKS 367
                ..||.|....|:                      .|.:...:|...|   :||....||..
Human   221 HQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHH 285

  Fly   368 FSSILNFYRT-------------GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKY-HQRKE 418
            ...  ::::|             |..|             ..|...|  |::|..|... |..:.
Human   286 TQH--HYHQTHRHRDYHQHQDHHGAYH-------------SSYLHGD--YVQSTSQLSIPHTSRS 333

  Fly   419 NVHE------------------------EMRKEAESLRQR-----------------------DE 436
            .:|:                        .|.:.:.::|.|                       :|
Human   334 LIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEE 398

  Fly   437 EEFGEGKCAEYQK------------YLWELLEKPNTSFAARV------IAVISILFIV--LSTIA 481
            .:|.:.|....|:            :|||.|......|...:      :|..:.:|.|  |:|:.
Human   399 GQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVM 463

  Fly   482 LTLNTLPQLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASP-----DKWK---FFKGGLN 538
            |...|..:::      .:.......::::....:.:|.:|:..|..     |.|.   ||...:.
Human   464 LVAQTFAEVE------IRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMA 522

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARH---STGLQSLGFTL 600
            ::|.|          |::|:..|. ..|.:.|:::||:.:|.||.:::.|.   .|.:|.:..||
Human   523 VLDFL----------LMQTHSFAI-YHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTL 576

  Fly   601 RNSYKELGLLMLFLAMGVLIFSSL--AYFAEKDEKDTKFVSIPETFW----------WAGITMTT 653
            ..|...:..:::.:...:.:||::  |.|.:.|.|  :|.:|..|.:          |:.|.|.:
Human   577 GQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPK--RFQNIFTTIFTLFTLLTLDDWSLIYMDS 639

  Fly   654 VGYGDIYPTTALGKVIGTVCCICGVLVI----------ALPIPIIVNNF-AEFYK--NQMRREKA 705
            ...|..|              |..:|||          .|.|.::|::| ...:|  .:.::|:|
Human   640 RAQGAWY--------------IIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERA 690

  Fly   706 LKRREAL-------------DRAKREGSIVS------------------FHHINL-------KDA 732
            .:.:|.|             .....||:::.                  ||::.|       :..
Human   691 ARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQK 755

  Fly   733 FAKSMDLIDVIVDT 746
            |.....:||.||||
Human   756 FRSQAAVIDEIVDT 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	23/155 (15%)
		Ion_trans	464..700	CDD:459842	55/279 (20%)
CATSPER1	NP_444282.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..306		48/314 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	376..412		4/35 (11%)
		Ion_trans	446..677	CDD:459842	54/263 (21%)