DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and Kcnb2

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_446452.2 Gene:Kcnb2 / 117105 RGDID:621349 Length:907 Species:Rattus norvegicus


Alignment Length:849 Identity:393/849 - (46%)
Similarity:511/849 - (60%) Gaps:138/849 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 LQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEA 344
            |.|..|||..|: ||||..|.:||..:.||.|||||:.||||||||:|||.||||:||:|.|||:
  Rat     9 LNRKTSRSTLSL-PPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHES 72

  Fly   345 IVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCC 409
            ::|:||||:|.:|||||||||.:|:||||||||||||:::|||.|:|..:|:|||:||:||||||
  Rat    73 LLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCC 137

  Fly   410 QHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILF 474
            |.:|||:||.::||:|:|||::|:|:.|||....|.|.:|.||:||||||:|.||:::|::||||
  Rat   138 QARYHQKKEQMNEELRREAETMREREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILF 202

  Fly   475 IVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
            ||||||||:|||||:||..|. |.|.||.:||.||||||.|||:||:|||.:||:|||||||.||
  Rat   203 IVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLN 267

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            :|||||||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.|
  Rat   268 VIDLLAILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRS 331

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            |.|||||:||||||::|||||.:||||||..|||.|||.:||||.|||||||||||||.|.|||:
  Rat   332 YNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKI 396

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAF 733
            :|.:|||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :||||||
  Rat   397 VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNLKDAF 458

  Fly   734 AKSMDLIDVIVD-TGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRN 797
            |:||:||||.|: .|:..|:.........:|:..:.....       ||:|..|.:         
  Rat   459 ARSMELIDVAVEKAGESANIKDSVDDNHLSPSRWKWARKA-------LSETSSNKS--------- 507

  Fly   798 PATTGTGCYKN-YDHVANLRNSNLHNRRGSSSEQ--------------DAVPPYSFDNPNARQTS 847
                    |:| |..|:...:....|...|||.|              .....:|..||:.::  
  Rat   508 --------YENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQTHSHPNPDCQE-- 562

  Fly   848 MMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVAT 912
                   :.|:.:..:::.:.::.:...:|:              .||....:|...|.::..:.
  Rat   563 -------QPERPSAYEEEIEMEEVVCPQEQL--------------AVAQTEVIVDMKSTSSIDSF 606

  Fly   913 ATNASNASNT------APGSEGAEGGGDGDGGGVDDD---------NLSQAKG----------LP 952
            .:.|::.:.|      .|.:...:.....|..|:|:.         .||:.||          .|
  Rat   607 TSCATDFTETERSPLPPPSASHLQMKFPTDLPGMDEHQRVRAPPFLTLSRDKGPAAREAALDYAP 671

  Fly   953 IQMMIT-----------PGEVAE-----------LRRQVALENLQNQRMDNLEQDVPVEFECCFC 995
            |.:.:.           |...::           |:.:....|.|..| .:..|..|........
  Rat   672 IDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENR-GSAPQTPPSTARPLPV 735

  Fly   996 TTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAAAGRQAGAYGLLSPLPAPLPPLH--GPLLALP 1058
            ||.||          .|.|......|.||..|....|         |||......|  ||...|.
  Rat   736 TTADF----------PLTTPQHMSTILLEEALPQGQR---------PLPGADVSAHCQGPSKGLS 781

  Fly  1059 PPPP 1062
            |..|
  Rat   782 PRVP 785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585 75/106 (71%)
BTB_2 309..408 CDD:280393 69/98 (70%)
Ion_trans 501..700 CDD:278921 154/198 (78%)
Ion_trans_2 613..696 CDD:285168 64/82 (78%)
Kcnb2NP_446452.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 6/13 (46%)
BTB_POZ_KCNB2 19..145 CDD:349719 85/126 (67%)
Ion_trans 192..428 CDD:395416 179/236 (76%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 4/4 (100%)
Kv2channel 471..755 CDD:397541 52/341 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..570 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..860 27/126 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 884..907
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 362 1.000 Domainoid score I919
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002877
OrthoInspector 1 1.000 - - otm46099
orthoMCL 1 0.900 - - OOG6_101602
Panther 1 1.100 - - O PTHR11537
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.910

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