DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shab and Kcnb2

DIOPT Version :10

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_446452.2 Gene:Kcnb2 / 117105 RGDID:621349 Length:907 Species:Rattus norvegicus


Alignment Length:849 Identity:393/849 - (46%)
Similarity:511/849 - (60%) Gaps:138/849 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 LQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEA 344
            |.|..|||..|: ||||..|.:||..:.||.|||||:.||||||||:|||.||||:||:|.|||:
  Rat     9 LNRKTSRSTLSL-PPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHES 72

  Fly   345 IVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCC 409
            ::|:||||:|.:|||||||||.:|:||||||||||||:::|||.|:|..:|:|||:||:||||||
  Rat    73 LLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCC 137

  Fly   410 QHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILF 474
            |.:|||:||.::||:|:|||::|:|:.|||....|.|.:|.||:||||||:|.||:::|::||||
  Rat   138 QARYHQKKEQMNEELRREAETMREREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILF 202

  Fly   475 IVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
            ||||||||:|||||:||..|. |.|.||.:||.||||||.|||:||:|||.:||:|||||||.||
  Rat   203 IVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLN 267

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            :|||||||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.|
  Rat   268 VIDLLAILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRS 331

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            |.|||||:||||||::|||||.:||||||..|||.|||.:||||.|||||||||||||.|.|||:
  Rat   332 YNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKI 396

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAF 733
            :|.:|||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :||||||
  Rat   397 VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNLKDAF 458

  Fly   734 AKSMDLIDVIVD-TGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTSGRN 797
            |:||:||||.|: .|:..|:.........:|:..:.....       ||:|..|.:         
  Rat   459 ARSMELIDVAVEKAGESANIKDSVDDNHLSPSRWKWARKA-------LSETSSNKS--------- 507

  Fly   798 PATTGTGCYKN-YDHVANLRNSNLHNRRGSSSEQ--------------DAVPPYSFDNPNARQTS 847
                    |:| |..|:...:....|...|||.|              .....:|..||:.::  
  Rat   508 --------YENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQTHSHPNPDCQE-- 562

  Fly   848 MMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVAT 912
                   :.|:.:..:::.:.::.:...:|:              .||....:|...|.::..:.
  Rat   563 -------QPERPSAYEEEIEMEEVVCPQEQL--------------AVAQTEVIVDMKSTSSIDSF 606

  Fly   913 ATNASNASNT------APGSEGAEGGGDGDGGGVDDD---------NLSQAKG----------LP 952
            .:.|::.:.|      .|.:...:.....|..|:|:.         .||:.||          .|
  Rat   607 TSCATDFTETERSPLPPPSASHLQMKFPTDLPGMDEHQRVRAPPFLTLSRDKGPAAREAALDYAP 671

  Fly   953 IQMMIT-----------PGEVAE-----------LRRQVALENLQNQRMDNLEQDVPVEFECCFC 995
            |.:.:.           |...::           |:.:....|.|..| .:..|..|........
  Rat   672 IDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENR-GSAPQTPPSTARPLPV 735

  Fly   996 TTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAAAGRQAGAYGLLSPLPAPLPPLH--GPLLALP 1058
            ||.||          .|.|......|.||..|....|         |||......|  ||...|.
  Rat   736 TTADF----------PLTTPQHMSTILLEEALPQGQR---------PLPGADVSAHCQGPSKGLS 781

  Fly  1059 PPPP 1062
            |..|
  Rat   782 PRVP 785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB_POZ_Shab-like 306..414 CDD:349720 74/107 (69%)
Ion_trans 464..700 CDD:459842 179/236 (76%)
Kcnb2NP_446452.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 6/13 (46%)
BTB_POZ_KCNB2 19..145 CDD:349719 85/126 (67%)
Ion_trans 192..428 CDD:459842 179/236 (76%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 4/4 (100%)
Kv2channel 471..755 CDD:397541 52/341 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..570 4/28 (14%)
FFAT. /evidence=ECO:0000250|UniProtKB:Q92953 605..611 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..860 27/126 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 884..907
Blue background indicates that the domain is not in the aligned region.

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