Protein Alignment Shab and Kcns1

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_446406.1
• Gene: Kcns1 / 117023
• RGDID: 621524
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 189/540 - (35%)
• Similarity: 294/540 - (54%)
• Gaps: 86/540 - (15%)

  Fly   298 MIAQSKAVNSRV---------SINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYS 353
            |:::.....|||         .:||||||..:..|.|.|.|.||||||:...:.|....|||||.
  Rat     1 MVSEFPGPGSRVPWRPRDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAVSEEQARRLCDDYD 65

  Fly   354 LADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKE 418
            .|..|::|||||..|..:|:|||||.||::||:||.||..:.:|||:.|..|.:||:.:|.:|:.
  Rat    66 AAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERRV 130

  Fly   419 NVHEEMRKEAE------------SLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVIS 471
            .......::::            |..||:...:|..:|...::.||..:|.|..|..:::.:.:|
  Rat   131 TRPRAWDEDSDAPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVS 195

  Fly   472 ILFIVLSTIALTLNTLPQLQHIDNGTP-------------QDNPQLAMVEAVCITWFTLEYILRF 523
            |..::.|..|:.:::||:.|..:....             :|:|.|..:|..||.||:.|...|.
  Rat   196 IGVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRL 260

  Fly   524 SASPDKWKFFKGGLNIIDLLAILPYFVSLF---LLETNKNAT-DQFQDVRRVVQVFRIMRILRIL 584
            ..:|....||...||:||::::||::::|.   .|...:.|: ::..|:.:||||||:|||.|:|
  Rat   261 LLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDRRGASGEELGDLGKVVQVFRLMRIFRVL 325

  Fly   585 KLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGI 649
            |||||||||:|||.||::||:|:|:|:|:||:||.:||.:||.||  ||:..|.:||..:||..:
  Rat   326 KLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAE--EKNVGFDTIPACWWWGTV 388

  Fly   650 TMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDR 714
            :||||||||:.|.|..||:..:.|.:.|:||:||||.||.|.|:.||    ||:|||
  Rat   389 SMTTVGYGDVVPETVAGKLAASGCILGGILVVALPITIIFNKFSHFY----RRQKAL-------- 441

  Fly   715 AKREGSIVSFHHINLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779
               |.::.|......:|..:....:.||.::|.::|:
  Rat   442 ---EAAVRSSGQREFEDLLSSVDGVSDVSLETSRETS---------------------------- 475

  Fly   780 LSQTDGNSTEGESTSGRNPA 799
               .:|.||:.|:.:...||
  Rat   476 ---QEGRSTDLETQAPSEPA 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	54/116 (47%)
		Ion_trans	464..700	CDD:459842	104/252 (41%)
Kcns1	NP_446406.1	BTB_POZ	21..126	CDD:453885	51/104 (49%)
		Ion_trans	188..439	CDD:459842	106/256 (41%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	392..397		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..497		10/60 (17%)