DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and Kcnd1

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001099218.1	Gene:	Kcnd1 / 116695	RGDID:	621364	Length:	650	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	209/677 - (30%)
Similarity:	309/677 - (45%)	Gaps:	128/677 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 PPEPFMIAQSKAVNSR----VSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYS 353
            ||.|    :.||  ||    :.:||.|.|.|....||:|.|.|.||...:...::|
  Rat    28 PPAP----EVKA--SRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDA--------- 77

  Fly   354 LADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKE 418
             ...||||||.|..|..:|||||||:||...:.|:.||.::|.::|:....:..||..:|..||
  Rat    78 -ESGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRK- 140

  Fly   419 NVHEEMRKEAESLRQRDE-EEFGEGKC----AEYQKYLWELLEKPNTSFAARVIAVISILFIVLS 478
                  ::.||.|.:.:| |:.|||..    :..::.||...|.|:||.||.|...::..||.:|
  Rat   141 ------KENAERLAEDEEAEQAGEGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVS 199

  Fly   479 TIALTLNTLP---------QLQHIDNGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFK 534
            .||..:.|:|         :.|...:..|   .....::..|:..||.||:||..|:|.:.:|.:
  Rat   200 VIANVVETIPCRGPARWPTKEQPCGDRFP---TAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLR 261

  Fly   535 GGLNIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFT 599
            ..:::||::|||||::.||:   .||     .||.......|:.|:.||.|.:|||.||:.||:|
  Rat   262 SVMSLIDVVAILPYYIGLFV---PKN-----DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYT 318

  Fly   600 LRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTA 664
            |::...|||.|:..|.|.::||:::.::|||....|.|.|||..||:..:||||:||||:.|:|.
  Rat   319 LKSCASELGFLLFSLTMAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTI 383

  Fly   665 LGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSFHH 726
            .||:.|::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..|..:.|:..:|..
  Rat   384 AGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQ 448

  Fly   727 INLKDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPG---------HNLSQ 782
            .                    ||...:...|..:.      |.|.|:|...         |.|.:
  Rat   449 Y--------------------KQNGGLEDSGSGEG------QMLCVRSRSAFEQQHHHLLHCLEK 487

  Fly   783 TDGNSTEGE----------STSGRNPATT-------GTG------CYKNYDHVA-NLRNSNLHNR 823
            |..:....|          |..||...:|       |.|      |.:..:..| .|.||.....
  Rat   488 TTCHEFTDELTFSEALGAVSLGGRTSRSTSVSSQPMGPGSLFSSCCSRRGERRAIRLANSTASVS 552

  Fly   824 RGSSSEQDAV-------PPYSFDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQK 881
            |||..|.|.:       .|.|..:.||:....:.:....|:..|.:..............|
  Rat   553 RGSMQELDTLAGLRRSPAPQSRSSLNAKPHDSLDLNCESRDFVAAIISIPTPPANTPDESQ---- 613

  Fly   882 APNGNGGATGGGVANNLAMVAASSAAT 908
             |:..||...||:||  ..:..||.||
  Rat   614 -PSSPGGGGSGGMAN--TTLRNSSLAT 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	38/106 (36%)
		BTB_2	309..408	CDD:280393	35/98 (36%)
		Ion_trans	501..700	CDD:278921	83/198 (42%)
		Ion_trans_2	613..696	CDD:285168	41/82 (50%)
Kcnd1	NP_001099218.1	BTB_POZ	6..143	CDD:365784	47/137 (34%)
		Ion_trans	185..417	CDD:395416	94/242 (39%)
		DUF3399	447..550	CDD:403174	22/128 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810