DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shab and Kcnq3

DIOPT Version :9

Sequence 1:NP_001189037.1 Gene:Shab / 38352 FlyBaseID:FBgn0262593 Length:1607 Species:Drosophila melanogaster
Sequence 2:NP_690887.2 Gene:Kcnq3 / 110862 MGIID:1336181 Length:873 Species:Mus musculus


Alignment Length:871 Identity:172/871 - (19%)
Similarity:303/871 - (34%) Gaps:247/871 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   443 KCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIAL-TLNTLPQLQHIDNGTPQDNPQLAM 506
            |....|..:::.||:|. .:|....|:  :..|||..:.| .|.|..:.:.:      ....|.:
Mouse   104 KYRRIQTLIYDALERPR-GWALLYHAL--VFLIVLGCLILAVLTTFKEYETV------SGDWLLL 159

  Fly   507 VEAVCITWFTLEYILRFSASP--DKWKFFKGG----------LNIIDLLAILPYFVSLFLLETNK 559
            :|...|..|..|:.||..|:.  .::|.::|.          |:|..|:|.:|  |.....:.|.
Mouse   160 LETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVP--VVAVGNQGNV 222

  Fly   560 NATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGV 618
            .||.        ::..|.::|||:|::.|.....:.||..:....|||      |.|.|.|:   
Mouse   223 LATS--------LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILS--- 276

  Fly   619 LIFSSLAYFAEKD---------EKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCC 674
               |.|.|..|||         |...:|.:..:..||..||:.|:||||..|.|..|::|.....
Mouse   277 ---SFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFS 338

  Fly   675 ICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRR----EALDRAKR-----------------E 718
            :.||...|||..|:.:..|...:.|.|::...|||    |.:..|.|                 .
Mouse   339 LIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRLDLVATWRFY 403

  Fly   719 GSIVSFHHI---NLKDAFAKSMDLID-VIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779
            .|:|||...   .|:.|.::.:.|:| |.:...:.:|.   |||..:..|:..    ::.:|...
Mouse   404 ESVVSFPFFRKEQLEAAASQKLGLLDRVRLSNPRGSNT---KGKLFTPLNVDA----IEESPSKE 461

  Fly   780 LSQTDGNSTEGESTSGRNPA--------TTGTGCYKNYDHVANLRNSNLHNRRGSSSE---QDAV 833
            ......|:.|...|:.|..|        ..|||     |.:|        ..||..::   :|.:
Mouse   462 PKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTG-----DPMA--------EDRGYGNDFLIEDMI 513

  Fly   834 PPYSFDNPNARQTSMMAMESYRR---------EQQALLQQQQQQQQQML-QMQQIQQKAPNGNGG 888
            |..   ....|...::....|::         :.:.:::|.......|| :::.:|.:       
Mouse   514 PTL---KAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR------- 568

  Fly   889 ATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPI 953
                     :.|:......:......:...::.|.|..:...          ::..:::|.....
Mouse   569 ---------IDMIFTPGPPSTPKHKKSQKGSAFTYPSQQSPR----------NEPYVARAATSET 614

  Fly   954 QMMITPGEVAELRRQV--------ALENLQNQRMDNLEQDV-----------PVEFECCFCTTKD 999
            :.....|:..::.|||        .|.::..|.|:.|:..|           |.|.|     .|:
Mouse   615 EDQSMMGKFVKVERQVHDMGKKLDFLVDMHMQHMERLQVHVTEYYPTKGASSPAEGE-----KKE 674

  Fly  1000 FKEFTDAEGVISL--------PTSDFHK-PICLEMRLAAAGRQAGAYGLLSPLPAPLP------- 1048
            ...::|.:.:|..        |...||: ||          .:.|.||..:..|..|.       
Mouse   675 DNRYSDLKTIICNYSETGPPDPPYSFHQVPI----------DRVGPYGFFAHDPVKLTRGGPSST 729

  Fly  1049 ------PLHGPLLALPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTT------------------ 1089
                  |..|...|..|           .:||.::...|..|.:..|                  
Mouse   730 KAQANLPSSGSTYAERP-----------TVLPILTLLDSCVSYHSQTELQGPYSDHISPRQRRSI 783

  Fly  1090 ---TSTTIALPLDVSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADL 1151
               :.|.::|   :|:.:.....|.|.|  :.:.:.:....|..|..:.:....|......:.| 
Mouse   784 TRDSDTPLSL---MSVNHEELERSPSGF--SISQDRDDYVFGPSGGSSWMREKRYLAEGETDTD- 842

  Fly  1152 ASVDSSDTYASCQTHPFLSQGDLTAD 1177
                 :|.:....:.|..|.||..:|
Mouse   843 -----TDPFTPSGSMPMSSTGDGISD 863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShabNP_001189037.1 BTB 309..416 CDD:197585
BTB_2 309..408 CDD:280393
Ion_trans 501..700 CDD:278921 62/225 (28%)
Ion_trans_2 613..696 CDD:285168 29/91 (32%)
Kcnq3NP_690887.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
Ion_trans 140..364 CDD:278921 65/245 (27%)
Ion_trans_2 270..354 CDD:285168 30/89 (34%)
Selectivity filter. /evidence=ECO:0000250 317..322 3/4 (75%)
Mediates interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:O43525 357..538 40/203 (20%)
KCNQ_channel 453..657 CDD:281513 34/249 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..603 2/37 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..742 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..873 16/109 (15%)
KCNQC3-Ank-G_bd 781..867 CDD:288784 16/94 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.