Protein Alignment Shab and kcnq2b

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_068078185.1
• Gene: kcnq2b / 100537363
• ZFINID: ZDB-GENE-120130-1
• Length: 872
• Species: Danio rerio
• Alignment Length: 933
• Identity: 186/933 - (19%)
• Similarity: 335/933 - (35%)
• Gaps: 284/933 - (30%)

  Fly   448 QKYLWELLEKPNTSFAARVIAVI---SILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLAMVE 508
            |.:|:.:||:|      |..|.|   .:..:|.|.:.|:: :|:.:.:      ......|.::|
Zfish    78 QNFLYNVLERP------RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYE------KSSEDALYILE 130

  Fly   509 AVCITWFTLEYILR-FSAS--------PDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKN--AT 562
            .|.|..|.:|||:| :||.        ..:.||.:....:||::.::. .:|:....|..|  ||
Zfish   131 IVTIVVFGVEYIVRIWSAGCCCRYRGWRGRLKFARKPFCVIDIMVLIA-SISVLAAGTQGNVFAT 194

  Fly   563 DQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGVLIF 621
            .       .::..|.::|||::::.|.....:.||..:....|||      |.|.|.||
Zfish   195 S-------AIRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLCLILA------ 246

  Fly   622 SSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIP 686
            |.|.|.|||::.: .|.:..:..||..||:||:||||.||.|..|:::.....:.||...|||..
Zfish   247 SFLVYLAEKEDNE-MFETYADALWWGLITLTTIGYGDKYPITWNGRLLAATFTLIGVSFFALPAG 310

  Fly   687 IIVNNFAEFYKNQMRREKALKRRE----ALDRAKREGSIVSFHHINLK--------DAFAKSMDL 739
            |:.:.||...:.|.|::...|||.    .:..|.|      |:..||.        |.:.:::.:
Zfish   311 ILGSGFALKVQEQHRQKHFEKRRNPAAGLIQAAWR------FYATNLNRTDLYSTWDYYERTISV 369

  Fly   740 -----------IDVIVDTGKQTNVVHPKGKRQSTPNIGRQTL---DVQSAPGHNLSQTDG-NSTE 789
                       :|::.:...::.:...| :.|..|:..::..   .|.|:|.:  |.|.| ||.:
Zfish   370 PMYRLIPPLNQLDLLRNLKSKSGLSFRK-EAQPEPSPSQKVSLKERVFSSPRN--SATKGKNSPQ 431

  Fly   790 GESTSGRNPATTG-----TGCYKNYDHVANLRNSNLHNRRGSSSEQD----AVPPYSF--DN--- 840
            |:.:..|:|:...     :...|:.......|.......:|::|.|:    ::|....  ||
Zfish   432 GQQSLRRSPSANSIEDSPSKVPKSLSFGDRNRARQAFRFKGAASRQNSEEASLPGEDIVDDNKSC 496

  Fly   841 ----------PNARQT-----SMMAMESYRREQQAL--------LQQQQQQQQQML-QMQQIQQK 881
                      |..:.|     .|..|.|.|:.:::|        ::|.......|| :::.:|.:
Zfish   497 HCEFVPQDLTPGLKVTIRAVCIMRFMVSKRKFKESLRPYDVMDVIEQYSAGHLDMLARIKNLQSR 561

  Fly   882 APNGNGGATGGGVANNLAMVAASSAATAVATATNASNASNTAPGSEGAEGGGDGDGGGVDDDNLS 946
                            |.|:......:.......::..|..:|..........|.|..:.|.:
Zfish   562 ----------------LDMILGPPGPSTPRPKKCSTKGSKESPQWSSRVDQIVGRGAPITDKD-- 608

  Fly   947 QAKG-----LP--IQMMITPGEVAELRRQVA--------LENLQNQRMDNLEQDVPVEFECCFCT 996
            :.||     ||  ..||   |.:.::.:||.        |.|:..|||     .:|......:..
Zfish   609 RPKGTTDGELPEDPSMM---GRLGKVEKQVMSMERKLDFLVNIYIQRM-----GIPQSETDAYFA 665

  Fly   997 TKDFKEFTDAEGVISLPTSDFHKPICLEM------RLAAAGRQAGAYGLLSP------------- 1042
            :|:    .|       |...:|.|:...:      ::..:...||......|
Zfish   666 SKE----PD-------PAPPYHSPVEHMVKSGSINKIIRSNSSAGQKNFDPPPSTCVNHHCPPST 719

  Fly  1043 --LPAPLP-------PLHGPLLALPPPPPLPPTSCAAVL-----------LPAISQSSSTSSSYG 1087
              .|...|       |:..|.|...||||....|.....           .||.....::.:..|
Zfish   720 SWHPQTAPEAGQGSSPMGDPSLVRIPPPPANERSSGGHSGGSRGHHHSRGTPAEDGRPASQAQAG 784

  Fly  1088 TTTSTTIALPL----DVSLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNN 1148
            ..:.|:|::|.    ::...:.....|.|..|.::.||             ..|.|
Zfish   785 AESDTSISIPSVDHEELERSFSGFSISQSKENLDFLNN-------------AYFSG--------- 827

  Fly  1149 ADLASVDSSDTYASC-QTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGISSSTGFI 1212
                       .:.| :..|::::|:  :|.:.:.||
Zfish   828 -----------VSRCTKVRPYIAEGE--SDTDSDLCA---------------------------- 851

  Fly  1213 VGLPSTNSSGGPRAQVKKSASGD 1235
               ||.:|:.|..|...:..:|:
Zfish   852 ---PSPHSATGDGAYADRGWTGN 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	71/256 (28%)
kcnq2b	XP_068078185.1	Ion_trans	92..324	CDD:459842	70/252 (28%)
		KCNQ_channel	439..656	CDD:460954	41/242 (17%)
		KCNQ2_u3	670..751	CDD:465213	16/87 (18%)
		KCNQC3-Ank-G_bd	783..869	CDD:463411	22/151 (15%)