DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shab and kcnv2

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_002934230.1	Gene:	kcnv2 / 100498412	XenbaseID:	XB-GENE-940169	Length:	562	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	176/489 - (35%)
Similarity:	274/489 - (56%)	Gaps:	60/489 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 INVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFY 375
            |||||..:.:.:......|.:|:|||...|..:..::||||||..::.|||||.|..|..|.|||
Frog   112 INVGGTSYRISYGVAASYPKSRIGRLATYTDRQRKLDLCDDYSPKEDVYFFDRDPAIFHHIYNFY 176

  Fly   376 RTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKE----AESLRQRDE 436
            |||.|.:.||:|..:|.:::.||||...:...||:..:.:|:::::|:::.:    ||...:.:|
Frog   177 RTGVLWVRDELCPRSFLEEINYWGVRVKHTPRCCRISFEERQDDLNEQLKVQRELRAEMETEENE 241

  Fly   437 EEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHID-NGTPQD 500
            |.|........::.:|.::|||.:|..|:.|||.|..|:::|.:|:||||:..:|:.: .|.|..
Frog   242 ELFRGMLYGHLRRRIWNMMEKPFSSVTAKAIAVASSFFVLISVVAMTLNTVEDMQYKNAAGLPSG 306

  Fly   501 NPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLE-------TN 558
            .|.|..||.:|||:|||||:||..::||...|.:..||.:||:||||.::.: |||       :.
Frog   307 KPYLEHVETLCITFFTLEYLLRLMSTPDLQHFGRSVLNAVDLIAILPLYLQM-LLESFADEDRSG 370

  Fly   559 KNATDQFQ--------DVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLA 615
            |.::.:.:        .:.:|:::.|:|||.||||||||||||::.|||||..|:::|.|.||:|
Frog   371 KGSSHEHEIEAVGRVGKLGQVLRIMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLFLFIA 435

  Fly   616 MGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLV 680
            |||..||::.|..|.|...|.|.|||..:|||.::::||||||:||.|.||::...:|...|:::
Frog   436 MGVFSFSAMVYSVEHDVSGTNFTSIPHAWWWAAVSISTVGYGDVYPETHLGRLFAFLCIAFGIIL 500

  Fly   681 IALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAFAKSMDLIDVIVD 745
            ..:||.|:.|.|:::|..       ||..|.....|:.|.:    |.
Frog   501 NGMPISILYNKFSDYYSK-------LKSYEYTTIRKKRGKV----HF------------------ 536

  Fly   746 TGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779
            ||:....|:........||          .||||
Frog   537 TGRAVQKVNSCCCGPPVPN----------TPGHN 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	42/104 (40%)
		BTB_2	309..408	CDD:280393	40/96 (42%)
		Ion_trans	501..700	CDD:278921	92/213 (43%)
		Ion_trans_2	613..696	CDD:285168	36/82 (44%)
kcnv2	XP_002934230.1	BTB	112..212	CDD:197585	42/99 (42%)
		BTB	112..201	CDD:295341	38/88 (43%)
		Ion_trans	310..520	CDD:278921	91/217 (42%)
		Ion_trans_2	445..508	CDD:285168	26/62 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010