Protein Alignment Shab and kcnb2

DIOPT Version :10

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: XP_002937117.3
• Gene: kcnb2 / 100489419
• XenbaseID: XB-GENE-989392
• Length: 901
• Species: Xenopus tropicalis
• Alignment Length: 1023
• Identity: 432/1023 - (42%)
• Similarity: 559/1023 - (54%)
• Gaps: 229/1023 - (22%)

  Fly   280 LQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEA 344
            |.|..|||..|: ||||..|.:|||.:.||.|||||:.||||||||:|||.||||:||:|.|||:
 Frog     9 LNRKTSRSTLSL-PPEPVEIIRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHES 72

  Fly   345 IVELCDDYSLADNEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCC 409
            ::|:||||:|.:|||||||||.:|:||||||||||||:::|||.|:|..:|:|||:||:||||||
 Frog    73 LLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCC 137

  Fly   410 QHKYHQRKENVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILF 474
            |.:|||:||.::||:|:|||:||:|:.|||....|.|.:|.||:||||||:|.||:::|:|||||
 Frog   138 QARYHQKKEQMNEELRREAETLREREGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIISILF 202

  Fly   475 IVLSTIALTLNTLPQLQHIDN-GTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLN 538
            ||||||||:|||||.||..|. |.|.||||||.||||||.|||:||:|||.:||:|||||||.||
 Frog   203 IVLSTIALSLNTLPDLQETDEFGQPNDNPQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLN 267

  Fly   539 IIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNS 603
            ||||||||||:|::||.|:||:.. |||:||||||:|||||||||||||||||||||||||||.|
 Frog   268 IIDLLAILPYYVTIFLTESNKSVL-QFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRS 331

  Fly   604 YKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKV 668
            |.|||||:||||||::|||||.:||||||..|||.|||.:||||.|||||||||||||.|.|||:
 Frog   332 YNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKI 396

  Fly   669 IGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVSFHHINLKDAF 733
            :|.:|||.||||||||||||||||:||||.|.|:|||:||||||:||||.|||||   :||||||
 Frog   397 VGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVS---MNLKDAF 458

  Fly   734 AKSMDLIDVIVD-TGKQTNVVHPKGKRQSTPN---IGRQTLDVQSAPGHNLSQTDGNS------- 787
            |:||:||||:|| :...:|.:........:|:   ..|:|          ||:|..|.
 Frog   459 ARSMELIDVVVDKSADGSNKMEKPSDNHLSPSRWKWSRRT----------LSETSSNKSFDNKYQ 513

  Fly   788 --TEGESTSGRNPATTGTGCYKNYDHVANLRNSNLHNR----------RGSSSEQDAVPPYSFDN 840
              ::.:|....|.|::..      .|::..:...|:|.          ..|..||.||||
 Frog   514 EVSQHDSQEQLNNASSSP------QHLSAQKLEELYNEITKAQSHPSVNSSFQEQAAVPP----- 567

  Fly   841 PNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANN---LAMVA 902
                        :|..|               ::|:::..|       .|...||..   ..|.:
 Frog   568 ------------AYEEE---------------IEMEEVSTK-------KTQLSVAQKDIVTDMRS 598

  Fly   903 ASSAATAVATATN-------------ASNASNTAPGSEGAEGGGDGDGGGVDDDNLSQAKGLPIQ 954
            .||..:..:.||:             .||.....|.....|.|.||        |::|.......
 Frog   599 VSSIDSFASCATDFTETERSPLTPYPGSNLEIRFPSYTVPEEGHDG--------NVTQILPRSKY 655

  Fly   955 MMITPGEVAELRRQVALENLQNQRMDN------LEQDVPVEFECCFCTTK------------DFK 1001
            |...|.:|.   .:..|....|:. ||      |:.....|.|...|:.:            :||
 Frog   656 MGFAPKDVT---FEYKLSERSNKN-DNGTPKILLQDQAGNEVESPECSLRRNNPLRSRSLKVNFK 716

  Fly  1002 E-----------FTDAEGVISLPTSDFHKPICLEMRLAAAGRQAGAYGLLSPLPA---------- 1045
            |           ||.|     ||.:....|:...::|:..        .|...|:
 Frog   717 EGKGMSQAGPTNFTSA-----LPVNMIDHPLYTHLQLSTI--------FLRDYPSQEQPSNLQTD 768

  Fly  1046 ---------PLPPLHGP-LLALPPPPPLPPTSCAAVLLPAISQSSSTSSSYGTTTSTTIALPLDV 1100
                     .:.|.|.| |.|||                  |...|:.:..||.....:
 Frog   769 SSSEHSRSLQVSPKHNPKLFALP------------------SNMKSSFTEIGTEDEDFM------ 809

  Fly  1101 SLRYGATICSSSNFNHNYNNNFNTTTVGGGGNGTLLFGGNYNGSNNNNADLASVDSSDTYAS--C 1163
                  .||...|   |...|..|........|..:           |.: .||.|.....|  |
 Frog   810 ------QICGEKN---NTQENMKTNCTEEKPEGHFV-----------NLE-TSVLSPQKIVSQNC 853

  Fly  1164 QTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGISSSTGF 1211
            ....:|.:.|...:.|.|...::   ::|::..:..:     :..||:
 Frog   854 TQDIYLPEVDSNQETNQEESKVE---NHLFVPEVHPD-----TGETGY 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	74/107 (69%)
		Ion_trans	464..700	CDD:459842	183/236 (78%)
kcnb2	XP_002937117.3	BTB_POZ_KCNB2	19..145	CDD:349719	86/126 (68%)
		Ion_trans	192..428	CDD:459842	183/236 (78%)
		Kv2channel	471..755	CDD:397541	64/363 (18%)