DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and si:dkey-43k4.5

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	XP_017212096.1	Gene:	si:dkey-43k4.5 / 100148290	ZFINID:	ZDB-GENE-120215-82	Length:	487	Species:	Danio rerio

Alignment Length:	455	Identity:	180/455 - (39%)
Similarity:	293/455 - (64%)	Gaps:	24/455 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 INVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFY 375
            |||||:|:.:....|::.|.||||:|..|.:.:.|::||||:.:...|::|||:|..|..:|:||
Zfish    20 INVGGLRNTLCSSILKKFPDTRLGQLLSCDSEDDILQLCDDFDVQRKEFYFDRNPGLFPYVLHFY 84

  Fly   376 RTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRK-ENVHEEMRKEAE---------- 429
            :||||||::|:|:.:||.::||||:.:.:|:|||.::|..|| |..|:...:|::
Zfish    85 QTGKLHIMEELCIFSFSQEIEYWGISDFFLDSCCSYRYLDRKLERHHKSWDEESDVSSVDTSVDE 149

  Fly   430 -SLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHI 493
             |...:|.|.|.|.:....:|.||..||.|..|..:::.:::||..:::|...:.:|::|:.|..
Zfish   150 ISDLNKDIEHFHEMRFGNIRKCLWLTLENPGYSIPSKLFSLLSICVVLISIATMCINSIPEYQKF 214

  Fly   494 D-NGTPQDNPQLAMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLET 557
            | ||...::|.:.::|..||.|||.|.:.|...:|:..|||...||:||:::::|.::::| .:.
Zfish   215 DENGNLIEDPTMHVLEVFCICWFTFEVVTRMLLAPNHRKFFLLPLNVIDIISVMPIYITIF-FDM 278

  Fly   558 NKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFS 622
            ...:..:..::.::|||.|:|||.|:||||||||||:|||.|||:||:|:|:|:|:||:||.:||
Zfish   279 LIGSESELGNLGKLVQVLRLMRIFRVLKLARHSTGLRSLGATLRHSYREVGILLLYLAVGVSVFS 343

  Fly   623 SLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPI 687
            .:||.|| :|:|....:||..:||..::||||||||:.|.|..||:..:.|.:.|.||:||||.|
Zfish   344 GMAYTAE-NEEDVGLDTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGTLVVALPITI 407

  Fly   688 IVNNFAEFYKNQMRREKALK---RREALDRAKREGSIVSFH-HIN-LKDAFAKSMDLIDVIVDTG 747
            |.|.|:.||:.|...|.:::   .::.:.|.:|.....:.| ||: |:|   :.|| .||..|||
Zfish   408 IFNKFSHFYRKQKALEASVRNNNNKKFVMRQQRNSGDSAIHGHIHCLED---EEMD-EDVDFDTG 468

Fly 748 747
Zfish 469 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	47/104 (45%)
		BTB_2	309..408	CDD:280393	43/96 (45%)
		Ion_trans	501..700	CDD:278921	91/198 (46%)
		Ion_trans_2	613..696	CDD:285168	40/82 (49%)
si:dkey-43k4.5	XP_017212096.1	BTB_2	20..117	CDD:308049	43/96 (45%)
si:dkey-43k4.5	XP_017212096.1	Ion_trans	185..420	CDD:306908	100/236 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920