DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shab and kcnd3

DIOPT Version :9

Sequence 1:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster
Sequence 2:	NP_001096411.1	Gene:	kcnd3 / 100125015	XenbaseID:	XB-GENE-5867971	Length:	653	Species:	Xenopus tropicalis

Alignment Length:	678	Identity:	202/678 - (29%)
Similarity:	318/678 - (46%)	Gaps:	115/678 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 PEPFMIA-QSKAVNSRVSINVGGVRHEVLWR-TLERLPHTRLGRLRECTTHEAIVELCDDYSLAD 356
            |.|...| ::|..:..:.:||.|.|.:. || ||||.|.|.||     :|.:...     ::...
Frog    26 PMPLAPADKNKRQDEVIILNVSGRRFQT-WRTTLERYPDTLLG-----STEKEFF-----FNEET 79

  Fly   357 NEYFFDRHPKSFSSILNFYRTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVH 421
            .||||||.|:.|..|||||||||||.....|:.|:.::|.::|:....:..||..:|..||
Frog    80 KEYFFDRDPEVFRCILNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRK---- 140

  Fly   422 EEMRKEAESLRQRDEEEFGEGKCA----EYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIAL 482
               |:.||  |..|:.||...:.|    ..::.:|...|.|:||..|.|...::..||.:|.|..
Frog   141 ---RENAE--RLMDDNEFENNQEAMPSLTLRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITN 200

  Fly   483 TLNTLPQLQHIDNGTPQDNPQLA----------MVEAVCITWFTLEYILRFSASPDKWKFFKGGL 537
            .:.|:|      .||...|.:|.          .::..|:..||:||:||..|:|.:::|.:..:
Frog   201 VVETVP------CGTVPGNKELPCGERYDVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFMRSVM 259

  Fly   538 NIIDLLAILPYFVSLFLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRN 602
            :|||::||:||::.|.:  ||.      :||.......|:.|:.||.|.:|||.||:.||:||::
Frog   260 SIIDVVAIMPYYIGLVM--TNN------EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKS 316

  Fly   603 SYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGK 667
            ...|||.|:..|.|.::||:::.::|||....:||.|||.:||:..:||||:||||:.|.|..||
Frog   317 CASELGFLLFSLTMAIIIFATVMFYAEKGSSSSKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGK 381

  Fly   668 VIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMRREK---ALKRREALDRAKREGSIVSFHHINL 729
            :.|::|.:.||||||||:|:||:||:..|....|.:|   ..|.|.|..|..:.||..::.|...
Frog   382 IFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSTAYLHSKR 446

  Fly   730 KDAFAKSMDLIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQTDGNSTEGESTS 794
            .....::::|:                |..:. |:||:....::|...|.|...:  .|.|.|..
Frog   447 NGLLNEALELM----------------GSTEE-PHIGKSASLIESQHHHLLHCLE--KTTGLSYL 492

  Fly   795 GRNP-ATTGTGCYKNYDHV------ANLRNSNLHNRRGSSSEQDAVPPYS--------------- 837
            ..:| .:..|...||::.:      .|.|.|::.|...|.|     |..|
Frog   493 VDDPLLSVRTSTMKNHEFMDEQMFEQNCRESSMQNYPSSRS-----PSLSSNHGLTTSCCSRRNK 552

  Fly   838 ----FDNPNARQTSMMAMESYRREQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNL 898
                ..|.|...|.:.:|:    |...:..|...|.........:..|:.:        .:.:|.
Frog   553 KTTHLPNSNVPATRLRSMQ----ELSTIHIQCSDQPSLTASRSSLNLKSDD--------ELRSNC 605

  Fly   899 AMVAASSAATAVATATNASNASNTAPGS 926
            .....::|..::.|....|....|.|||
Frog   606 KASQITTAIISIPTPPALSPEGETRPGS 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	41/107 (38%)
		BTB_2	309..408	CDD:280393	38/99 (38%)
		Ion_trans	501..700	CDD:278921	84/208 (40%)
		Ion_trans_2	613..696	CDD:285168	41/82 (50%)
kcnd3	NP_001096411.1	Shal-type	3..28	CDD:288455	1/1 (100%)
		BTB	42..139	CDD:197585	41/107 (38%)
		BTB_2	42..131	CDD:280393	38/99 (38%)
		Ion_trans	217..412	CDD:278921	82/202 (41%)
		Ion_trans_2	328..408	CDD:285168	41/79 (52%)
		DUF3399	442..563	CDD:288712	26/144 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910