Protein Alignment Shab and kcnd1

DIOPT Version :9

• Sequence 1: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Sequence 2: NP_001119942.1
• Gene: kcnd1 / 100001681
• ZFINID: ZDB-GENE-081105-40
• Length: 632
• Species: Danio rerio
• Alignment Length: 570
• Identity: 182/570 - (31%)
• Similarity: 285/570 - (50%)
• Gaps: 77/570 - (13%)

  Fly   311 INVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFY 375
            :||.|:|.:....||:|.|.|.||...:        |..  |:....||||||.|:.|..|||||
Zfish    44 VNVSGLRFQTWKNTLDRYPDTLLGSSEK--------EFF--YNEDTQEYFFDRDPEMFRHILNFY 98

  Fly   376 RTGKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDEEEFG 440
            |||:||...:.|:.||.::|.::|:....:..||..:|..||:...|.:..:.|:....|..
Zfish    99 RTGRLHYPRQECIQAFDEELAFYGIVPDIIGDCCMEEYRDRKKENQERLAVDTEAEMATDTP--- 160

  Fly   441 EGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLP--QLQHIDNGTPQDNP- 502
            ....:.:::.||...|.|:||..|.|...::..||.:|.||..:.|:|  .|:    |:.:|.|
Zfish   161 LPPHSTHRERLWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCRPLK----GSKKDLPC 221

  Fly   503 ----QLAM--VEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNA 561
                .||.  ::..|:..||.||::|..|:|.:.||.:..:::||::||:||::.|.:.|.
Zfish   222 GEKYSLAFFCMDTACVLIFTFEYLMRLFAAPSRCKFMRSVMSVIDVVAIMPYYIGLVMPEN---- 282

  Fly   562 TDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAY 626
                :||.......|:.|:.||.|.:|||.||:.||:||::...|||.|:..|.|.::||:::.:
Zfish   283 ----EDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMF 343

  Fly   627 FAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNN 691
            :|||..|.|.|.|||.:||:..:||||:||||:.|.|..||:.|::|.:.||||||||:|:||:|
Zfish   344 YAEKGTKGTNFTSIPASFWYTIVTMTTLGYGDMVPNTIAGKIFGSICSLSGVLVIALPVPVIVSN 408

  Fly   692 FAEFYKNQMRREKALKRRE---------------ALDRAKREGSIVSFHH---INLKDAFAKSMD 738
            |:..|....|.:|...:::               |..:.|.||......|   :.||:..:....
Zfish   409 FSRIYHQNQRADKMRAQQKVRLARIRLAKKGTTNAFLQYKEEGGFHDRDHDGALCLKNRSSFEHQ 473

  Fly   739 LIDVIVDTGKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHNLSQ-TDGNSTEGESTSGRNPATTG 802
            ...::....|.||       .:.|..:....:.:..:.|:..|: |..:|.:|.|||
Zfish   474 HHHLLHCLEKTTN-------HEFTDELTFSEMCMTESVGYRTSRSTSISSQQGVSTS-------- 523

  Fly   803 TGCYKNYDHVA-NLRNSNLHNRRGSSSEQD-------AVPPYSFDNPNAR 844
             .|.:.....| .|.||.:...|||..|.|       .:.|.|..:.|||
Zfish   524 -CCPRRAKRRAIRLANSTVSVSRGSVQELDTLHVHKTTIRPQSRSSLNAR 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shab	NP_001189037.1	BTB	309..416	CDD:197585	39/104 (38%)
		BTB_2	309..408	CDD:280393	36/96 (38%)
		Ion_trans	501..700	CDD:278921	84/205 (41%)
		Ion_trans_2	613..696	CDD:285168	42/82 (51%)
kcnd1	NP_001119942.1	Shal-type	3..28	CDD:288455
		BTB_2	42..131	CDD:280393	36/96 (38%)
		BTB	44..132	CDD:197585	36/97 (37%)
		Ion_trans	217..415	CDD:278921	85/205 (41%)
		Ion_trans_2	331..411	CDD:285168	42/79 (53%)
		DUF3399	445..542	CDD:288712	23/112 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810