Protein Alignment KIF22 and KIP3

DIOPT Version :10

• Sequence 1: NP_015556.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 665
• Species: Homo sapiens
• Sequence 2: NP_011299.1
• Gene: KIP3 / 852655
• SGDID: S000003184
• Length: 805
• Species: Saccharomyces cerevisiae
• Alignment Length: 595
• Identity: 165/595 - (27%)
• Similarity: 256/595 - (43%)
• Gaps: 146/595 - (24%)

Human    80 RNHQETLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQP 144
            |.|...:|:.||..:.|.|:|..:|..:..|:|..:|:|.|::|.|||.||.|||:|:.|:|.||
Yeast   145 RRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSGTPSQP 209

Human   145 GVIPRALMDLL----QLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDP--ASGDLVIREDCRG 203
            |:|..|:.:|.    .|..|:..|       :::||||||.|::.|||.|  .|..||||||.:.
Yeast   210 GIIFLAMEELFNKITDLKDEKDFE-------ISLSYLEIYNERIRDLLKPETPSKRLVIREDTQN 267

Human   204 NILIPGLSQKPISSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQRE- 267
            :|.:..||....::..|.....:..:.|||...|..|:.||||||||.:.:.|..:|.....:.
Yeast   268 HIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDLTSQHT 332

Human   268 -GKLYLIDLAGSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDA--LNQGLP--RVPYRDSKLTR 327
             ..|.:|||||||....|.|:|:||.|...||.||..||..::|  ||.|..  .:|||||||||
Yeast   333 FATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSRSCHIPYRDSKLTR 397

Human   328 LLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTN-ESLQPHALGPVKLSQK 391
            ||:.||||:..:::|..|:|....|.:|::.|.:|.|:||:..:...| :||..|
Yeast   398 LLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRH---------- 452

Human   392 ELLGPPEAKRARGPEEEEIGSPEPMAAPASASQKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQ 456
                              :||
Yeast   453 ------------------VGS-------------------------------------------- 455

Human   457 GAPLLSTPKRERMVLMKTVEEKDLEIERLKTKQKELEAKMLAQKAEEKE------NHCPTMLRPL 515
                          .:|.:.|:..:||.|:.:::::.:..|.:....||      |.|...::
Yeast   456 --------------YLKMITEQKRQIEELREREEKMISLKLTKYKLNKEKIQLAINECVNRVQ-- 504

Human   516 SHRTVTG------AKPLKKAVVMPLQLIQEQAASPNAEIHILKNKGRKRKLESLDALEPEEKAED 574
              :|..|      ||.||..::...:.:|......:..|.:.:.       |...|.|.:....:
Yeast   505 --QTYAGVETYQVAKTLKSLILCKRRFLQMVKLEVDNLILLFER-------EESTAAEMQPVISN 560

Human   575 CWELQISPELLAHGRQKILDLLNEGSARD-----LRSLQRIGPKKAQLIVGWRE------LHGPF 628
            |  ..||.:|.    .||.:|..:....|     :..:..|...|.:.:..|.|      |....
Yeast   561 C--RMISGQLY----NKIHELEMKFDETDTLSSVIHQVHSIDLNKLREMEDWDETYDLVYLESCL 619

Human   629 SQVEDLERVE 638
            :|:.:|:|.|
Yeast   620 NQISELQRNE 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF22	NP_015556.1	KISc_KID_like	43..366	CDD:276827	119/297 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..428		3/48 (6%)
		ComEA	596..646	CDD:441164	10/54 (19%)
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	120/299 (40%)