Protein Alignment KIF22 and KIP3

DIOPT Version :9

• Sequence 1: XP_024306038.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 723
• Species: Homo sapiens
• Sequence 2: NP_011299.1
• Gene: KIP3 / 852655
• SGDID: S000003184
• Length: 805
• Species: Saccharomyces cerevisiae
• Alignment Length: 648
• Identity: 182/648 - (28%)
• Similarity: 290/648 - (44%)
• Gaps: 118/648 - (18%)

Human    80 RNHQETLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQP 144
            |.|...:|:.||..:.|.|:|..:|..:..|:|..:|:|.|::|.|||.||.|||:|:.|:|.||
Yeast   145 RRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSGTPSQP 209

Human   145 GVIPRALMDLL----QLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDP--ASGDLVIREDCRG 203
            |:|..|:.:|.    .|..|:..|       :::||||||.|::.|||.|  .|..||||||.:.
Yeast   210 GIIFLAMEELFNKITDLKDEKDFE-------ISLSYLEIYNERIRDLLKPETPSKRLVIREDTQN 267

Human   204 NILIPGLSQKPISSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQRE- 267
            :|.:..||....::..|.....:..:.|||...|..|:.||||||||.:.:.|..:|.....:.
Yeast   268 HIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDLTSQHT 332

Human   268 -GKLYLIDLAGSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDA--LNQGLP--RVPYRDSKLTR 327
             ..|.:|||||||....|.|:|:||.|...||.||..||..::|  ||.|..  .:|||||||||
Yeast   333 FATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSRSCHIPYRDSKLTR 397

Human   328 LLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTN-ESLQPHALGPVKL--S 389
            ||:.||||:..:::|..|:|....|.:|::.|.:|.|:||:..:...| :||..|....:|:  .
Yeast   398 LLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRHVGSYLKMITE 462

Human   390 QKELLGPPEAKRARGPEE----------------------EEIGSPEPMAAPASASQKLSPLQKL 432
            ||.     :.:..|..||                      |.:...:...|.....|....|:.|
Yeast   463 QKR-----QIEELREREEKMISLKLTKYKLNKEKIQLAINECVNRVQQTYAGVETYQVAKTLKSL 522

Human   433 SSMDPAMLERL-LSLDRLL------ASQGSQGAPLLSTPKRERMVLMKTVEEKDLEIERLKT--- 487
            .......|:.: |.:|.|:      .|..::..|::|..:.....|...:.|.:::.:...|
Yeast   523 ILCKRRFLQMVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHELEMKFDETDTLSS 587

Human   488 ---KQKELEAKMLAQKAEEKENH-------CPTMLRPLSHRTVTGAKPLKKAVVMPLQLIQEQAA 542
               :...::...|.:..:..|.:       |...:..|....:     |..:.:|..:|:.:...
Yeast   588 VIHQVHSIDLNKLREMEDWDETYDLVYLESCLNQISELQRNEI-----LVNSSIMTEKLMSDPGL 647

Human   543 SPNAEIHILKN--KGRKRKLESL--DALEPEEKAEDCWELQI-SPELLAHGRQKILDLLNEGSAR 602
              |:....|..  ..|...:||:  |.:..:|:.|......| :|:  ::.....::::|. :|.
Yeast   648 --NSRFKFLSKWLMNRTPNIESIIQDLVHIDEEFESFARTFIANPD--SNFTNTNINIINT-TAA 707

Human   603 DL----RSLQRIGPKKAQLIVGWRELHGPFSQVAAHWTGGGRGRGRPGTPETLSP---IDPVP 658
            ||    .:|||..                |||....||          :|: |||   |:|.|
Yeast   708 DLAVPAETLQRQN----------------FSQKKVKWT----------SPD-LSPSPMIEPQP 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF22	XP_024306038.1	KISc_KID_like	43..366	CDD:276827	119/297 (40%)
		ComEA	<596..632	CDD:333350	10/39 (26%)
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	120/299 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810