Protein Alignment KIF22 and kif22

DIOPT Version :10

• Sequence 1: NP_015556.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 665
• Species: Homo sapiens
• Sequence 2: NP_001107063.1
• Gene: kif22 / 561788
• ZFINID: ZDB-GENE-080204-34
• Length: 634
• Species: Danio rerio
• Alignment Length: 647
• Identity: 344/647 - (53%)
• Similarity: 439/647 - (67%)
• Gaps: 53/647 - (8%)

Human    34 GATRRPPPARVRVAVRLRPFVDGTAGASDPPCVRGMDSCSLEIANWRNHQETLKYQFDAFYGERS 98
            ||......:||||||||||::|.....|:..||||:....|||.||||..|||:||||.|:||.:
Zfish    10 GAAGSKRTSRVRVAVRLRPYMDKQDEKSEGSCVRGLGPQKLEIINWRNATETLQYQFDVFHGEET 74

Human    99 TQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREEGA 163
            |||:::..||:|||.|:|.||||||.||||||||||||||||.|||||||||:.::..|...:..
Zfish    75 TQQEVFLTSVKPILPHILNGQNASVFAYGPTGAGKTHTMLGSQEQPGVIPRAVKEVFNLVGAQKK 139

Human   164 EGRPWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLSQKPISSFADFERHFLPA 228
            |...|..|:.|||||||.|||||||.|.|.||.||||...|||||||:..|:||||||:.||:||
Zfish   140 EQDGWEYSIGMSYLEIYNEKVLDLLSPGSQDLPIREDKDRNILIPGLTHTPLSSFADFDTHFIPA 204

Human   229 SRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKE 293
            |.|||..:|:||||||||||:||:||.:.:|..|.||:.|||||:|||||||||||||:|:||||
Zfish   205 SLNRTTASTKLNQRSSRSHAILLIKVVKSQRGPPHRQQTGKLYLVDLAGSEDNRRTGNQGIRLKE 269

Human   294 SGAINTSLFVLGKVVDALNQGL-PRVPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVS 357
            |||||.|||.|.|||||||.|. .|||||||||||||||||||||||::|.|||||.::|.||.|
Zfish   270 SGAINLSLFTLSKVVDALNTGAGGRVPYRDSKLTRLLQDSLGGSAHSVMITNIAPEYKYYFDTFS 334

Human   358 ALNFAARSKEVINRPFTNESLQPHALGPVKLSQKEL----LGPPEAKRARGPEEEEIGSPEPMAA 418
            ||||||:||:::||||..|::....:.|.|.:::|.    .|.|:.||::..::.| .||.|
Zfish   335 ALNFAAKSKQIVNRPFVRETVLAPTIAPGKRTREEQEAGGSGEPQNKRSKEGKKAE-HSPSP--- 395

Human   419 PASASQKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQGAPLLSTPKRERMVLMKTVEEKDLEIE 483
                     ||...||.|.::|:|||:|:::          ::.:.:|||:.|:|||.:...||:
Zfish   396 ---------PLHPQSSPDSSVLDRLLALEKM----------MMGSAERERLNLLKTVAQSRKEIQ 441

Human   484 RLKTKQKELE--AKMLAQKAE--EKENH----CPTMLRPLSHRTVTGAKPLK-KAVVMPLQLIQE 539
            .||.||||||  |.|..::.|  |||:.    ..|.|.||..:..|.|||.| :|||.|||:.|.
Zfish   442 MLKEKQKELEDKANMFNKQKETTEKESKDALLFKTDLPPLHRKQSTAAKPRKQQAVVTPLQVSQV 506

Human   540 QAASPNAEI-----HILKNKGRKRKLESLDA-------LEPEEKAEDCWELQISPELLAHGRQKI 592
            |.....|.:     .::|.|  :.:.|..|.       |.|.|...  ||.::.|.||...|:||
Zfish   507 QPLQQCAVVCKPSQTLVKKK--RVQTEVCDGKENIGVDLPPVEDVN--WESRLDPALLEQSRKKI 567

Human   593 LDLLNEGSARDLRSLQRIGPKKAQLIVGWRELHGPFSQVEDLERVEGITGKQMESFLKANIL 654
            |..||.||.::|:|||:||.|||:||:||||::|.|:|||||:::||:|.|:..||:|||||
Zfish   568 LQTLNSGSLKELKSLQQIGDKKAKLIMGWREINGDFTQVEDLKKIEGVTVKRFSSFIKANIL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF22	NP_015556.1	KISc_KID_like	43..366	CDD:276827	220/323 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..428		11/52 (21%)
		ComEA	596..646	CDD:441164	30/49 (61%)
kif22	NP_001107063.1	KISc_KID_like	19..343	CDD:276827	220/323 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..406		16/61 (26%)
		GPS2_interact	393..468	CDD:464868	34/96 (35%)
		ComEA	571..620	CDD:441164	30/48 (63%)