Protein Alignment KIF22 and kif22

DIOPT Version :9

• Sequence 1: XP_024306038.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 723
• Species: Homo sapiens
• Sequence 2: NP_001107063.1
• Gene: kif22 / 561788
• ZFINID: ZDB-GENE-080204-34
• Length: 634
• Species: Danio rerio
• Alignment Length: 620
• Identity: 328/620 - (52%)
• Similarity: 417/620 - (67%)
• Gaps: 45/620 - (7%)

Human    34 GATRRPPPARVRVAVRLRPFVDGTAGASDPPCVRGMDSCSLEIANWRNHQETLKYQFDAFYGERS 98
            ||......:||||||||||::|.....|:..||||:....|||.||||..|||:||||.|:||.:
Zfish    10 GAAGSKRTSRVRVAVRLRPYMDKQDEKSEGSCVRGLGPQKLEIINWRNATETLQYQFDVFHGEET 74

Human    99 TQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREEGA 163
            |||:::..||:|||.|:|.||||||.||||||||||||||||.|||||||||:.::..|...:..
Zfish    75 TQQEVFLTSVKPILPHILNGQNASVFAYGPTGAGKTHTMLGSQEQPGVIPRAVKEVFNLVGAQKK 139

Human   164 EGRPWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLSQKPISSFADFERHFLPA 228
            |...|..|:.|||||||.|||||||.|.|.||.||||...|||||||:..|:||||||:.||:||
Zfish   140 EQDGWEYSIGMSYLEIYNEKVLDLLSPGSQDLPIREDKDRNILIPGLTHTPLSSFADFDTHFIPA 204

Human   229 SRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKE 293
            |.|||..:|:||||||||||:||:||.:.:|..|.||:.|||||:|||||||||||||:|:||||
Zfish   205 SLNRTTASTKLNQRSSRSHAILLIKVVKSQRGPPHRQQTGKLYLVDLAGSEDNRRTGNQGIRLKE 269

Human   294 SGAINTSLFVLGKVVDALNQGL-PRVPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVS 357
            |||||.|||.|.|||||||.|. .|||||||||||||||||||||||::|.|||||.::|.||.|
Zfish   270 SGAINLSLFTLSKVVDALNTGAGGRVPYRDSKLTRLLQDSLGGSAHSVMITNIAPEYKYYFDTFS 334

Human   358 ALNFAARSKEVINRPFTNESLQPHALGPVKLSQKEL----LGPPEAKRARGPEEEEIGSPEPMAA 418
            ||||||:||:::||||..|::....:.|.|.:::|.    .|.|:.||::..::.| .||.|
Zfish   335 ALNFAAKSKQIVNRPFVRETVLAPTIAPGKRTREEQEAGGSGEPQNKRSKEGKKAE-HSPSP--- 395

Human   419 PASASQKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQGAPLLSTPKRERMVLMKTVEEKDLEIE 483
                     ||...||.|.::|:|||:|:::          ::.:.:|||:.|:|||.:...||:
Zfish   396 ---------PLHPQSSPDSSVLDRLLALEKM----------MMGSAERERLNLLKTVAQSRKEIQ 441

Human   484 RLKTKQKELE--AKMLAQKAE--EKENH----CPTMLRPLSHRTVTGAKPLK-KAVVMPLQLIQE 539
            .||.||||||  |.|..::.|  |||:.    ..|.|.||..:..|.|||.| :|||.|||:.|.
Zfish   442 MLKEKQKELEDKANMFNKQKETTEKESKDALLFKTDLPPLHRKQSTAAKPRKQQAVVTPLQVSQV 506

Human   540 QAASPNAEIHILKNKGRKRKLESLDALEPEEK-------AEDC-WELQISPELLAHGRQKILDLL 596
            |.....|.:........|:|....:..:.:|.       .||. ||.::.|.||...|:|||..|
Zfish   507 QPLQQCAVVCKPSQTLVKKKRVQTEVCDGKENIGVDLPPVEDVNWESRLDPALLEQSRKKILQTL 571

Human   597 NEGSARDLRSLQRIGPKKAQLIVGWRELHGPFSQV 631
            |.||.::|:|||:||.|||:||:||||::|.|:||
Zfish   572 NSGSLKELKSLQQIGDKKAKLIMGWREINGDFTQV 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF22	XP_024306038.1	KISc_KID_like	43..366	CDD:276827	220/323 (68%)
		ComEA	<596..632	CDD:333350	23/36 (64%)
kif22	NP_001107063.1	KISc	19..351	CDD:214526	225/331 (68%)
		KISc_KID_like	19..343	CDD:276827	220/323 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..406		16/61 (26%)
		HHH_3	571..620	CDD:289597	23/36 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194325971
Domainoid	1	1.000	418	1.000	Domainoid score	I4197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32011
Inparanoid	1	1.050	601	1.000	Inparanoid score	I5260
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51545
OrthoDB	1	1.010	-	-		D453797at33208
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		oto49375
orthoMCL	1	0.900	-	-		OOG6_108211
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6129
SonicParanoid	1	1.000	-	-		X6252
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440