Protein Alignment KIF22 and kif22

DIOPT Version :9

• Sequence 1: XP_024306038.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 723
• Species: Homo sapiens
• Sequence 2: XP_031748433.1
• Gene: kif22 / 394855
• XenbaseID: XB-GENE-979888
• Length: 680
• Species: Xenopus tropicalis
• Alignment Length: 676
• Identity: 351/676 - (51%)
• Similarity: 453/676 - (67%)
• Gaps: 69/676 - (10%)

Human     1 MAAGGSTQQRRREMAAASAAAISGAGRCRLSKIGATRRPPPARVRVAVRLRPFVDGTAGASDPPC 65
            |...|..|:....||.            |:|.:...::|..|||||||||||:::.....:...|
 Frog     1 MVLTGPPQRESVSMAK------------RVSILDQHKKPSSARVRVAVRLRPYMEKEDEKAPAAC 53

Human    66 VRGMDSCSLEIANWRNHQETLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTG 130
            |||:||.||||.||||..||::||||||||:.:||::||.|||..||.|||.||||||.||||||
 Frog    54 VRGLDSQSLEIVNWRNQLETMQYQFDAFYGDSATQREIYMGSVCHILPHLLIGQNASVFAYGPTG 118

Human   131 AGKTHTMLGSPEQPGVIPRALMDLLQLTREE--GAEGRPWALSVTMSYLEIYQEKVLDLLDPASG 193
            |||||||||:|.||||||||:.||||:||..  |.|...|..::||||:|||||||:|||:|.:.
 Frog   119 AGKTHTMLGNPSQPGVIPRAVRDLLQMTRTAAGGHENENWTYTITMSYVEIYQEKVMDLLEPKNK 183

Human   194 DLVIREDCRGNILIPGLSQKPISSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRE 258
            ||.||||...||||||::||.|:||.||:.||:|||:||||.:|:||.||||||||||:||.:.:
 Frog   184 DLPIREDKDHNILIPGVTQKTINSFGDFDEHFIPASQNRTVASTKLNDRSSRSHAVLLIKVQKSQ 248

Human   259 RLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDALNQGLPRVPYRDS 323
            :::||||..|||||||||||||||||||:|:|||||||||:|||.|.||||||||||||:|||||
 Frog   249 QVSPFRQLTGKLYLIDLAGSEDNRRTGNQGIRLKESGAINSSLFTLSKVVDALNQGLPRIPYRDS 313

Human   324 KLTRLLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQPHALGPVKL 388
            ||||||||||||:|||::|||||||:::|.||::||||||:||::||:||:.|:.|..|..|...
 Frog   314 KLTRLLQDSLGGTAHSVMIANIAPEQKYYFDTLTALNFAAKSKQIINKPFSQETTQSIAALPAMK 378

Human   389 SQKELLGPPEAKRARGPEEEEIGSPEPMAAPASASQKLSPLQK--LSSMDPAMLERLLSLDRLLA 451
            ..:|     ||:.|.|..:.:....:...:..:.|...:..:|  |:::|||::||||.||::|.
 Frog   379 RPRE-----EAETAAGSRQRKKSKTDSTESSPNTSMDAASKRKLNLAALDPAVVERLLKLDKILT 438

Human   452 SQGSQGAPLLSTPKRERMVLMKTVEEKDLEIERLKTKQKELEAKMLAQKAE-EKE---------- 505
            .:|.:.|.||||||||||.|:|..||..:||||||.||||||.|.:..:|. ||.
 Frog   439 EKGMKEAQLLSTPKRERMALLKKWEESQMEIERLKEKQKELEQKAIEAEARLEKSTNSDCNLSDS 503

Human   506 --NHCPTMLRPLSHRTVTGAKPLKKAVVMPLQ----------LIQEQAASPNAE----------- 547
              :.| |...||..|..:.||..|...|:|:|          |..|:...|.:|
 Frog   504 SVSEC-TFRAPLRGRNTSTAKAKKVLRVLPMQGEHPGANGGVLATERHVDPESERSETLLGNSQL 567

Human   548 -------IHILKNKGRKRKLESLDALEPEEKAEDCWELQISPELLAHGRQKILDLLNEGSARDLR 605
                   |.:.:.|  |:|..|.|..|    .:..||:.:..:||..||::||.|||.||.::|:
 Frog   568 QSTIEEGIPVFEKK--KKKPVSCDGRE----NQPTWEVNVRTDLLESGRERILKLLNTGSVKELK 626

Human   606 SLQRIGPKKAQLIVGWRELHGPFSQV 631
            |||:||.|||:||:||||::|||..|
 Frog   627 SLQKIGDKKAKLIIGWREVNGPFKNV 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF22	XP_024306038.1	KISc_KID_like	43..366	CDD:276827	228/324 (70%)
		ComEA	<596..632	CDD:333350	23/36 (64%)
kif22	XP_031748433.1	KISc_KID_like	31..356	CDD:276827	228/324 (70%)
		HHH_3	617..665	CDD:403900	23/36 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	451	1.000	Domainoid score	I4700
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32011
Inparanoid	1	1.050	667	1.000	Inparanoid score	I5701
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51545
OrthoDB	1	1.010	-	-		D142221at32523
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		otm55217
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6252
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080