Protein Alignment KIF22 and Kif22

DIOPT Version :10

• Sequence 1: NP_015556.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 665
• Species: Homo sapiens
• Sequence 2: XP_063142300.1
• Gene: Kif22 / 293502
• RGDID: 1311886
• Length: 667
• Species: Rattus norvegicus
• Alignment Length: 644
• Identity: 531/644 - (82%)
• Similarity: 580/644 - (90%)
• Gaps: 14/644 - (2%)

Human    10 RRREMAAASAAAISGAGRCRLSKIGATRRPPPARVRVAVRLRPFVDGTAGASDPPCVRGMDSCSL 74
            ::||||:||    ||..| .|||.|.:||||.||||||||||||:|   .|.:||||||:|||||
  Rat    10 QQREMASAS----SGPSR-SLSKGGVSRRPPLARVRVAVRLRPFMD---EAKEPPCVRGIDSCSL 66

Human    75 EIANWRNHQETLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLG 139
            |:||||.:||||||||||||||:|||||:|.||||||||||||||||||||||||||||||||||
  Rat    67 EVANWRKYQETLKYQFDAFYGEKSTQQDVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLG 131

Human   140 SPEQPGVIPRALMDLLQLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGN 204
            ||||||||||||||||||||||.||||||.:||.|||||||||||||||||||||||||||||||
  Rat   132 SPEQPGVIPRALMDLLQLTREESAEGRPWDISVAMSYLEIYQEKVLDLLDPASGDLVIREDCRGN 196

Human   205 ILIPGLSQKPISSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQREGK 269
            ||||||:||||:||::||:|||||||||.|||||||||||||||||||||:|||||.||||||||
  Rat   197 ILIPGLTQKPITSFSEFEQHFLPASRNRVVGATRLNQRSSRSHAVLLVKVEQRERLTPFRQREGK 261

Human   270 LYLIDLAGSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDALNQGLPRVPYRDSKLTRLLQDSLG 334
            |||||||||||||||||:|:||||||||||||||||||||||||||||:||||||||||||||||
  Rat   262 LYLIDLAGSEDNRRTGNQGIRLKESGAINTSLFVLGKVVDALNQGLPRIPYRDSKLTRLLQDSLG 326

Human   335 GSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQPHALGPVKLSQKELLGPPEA 399
            ||||||||||||||||||.||:|||||.|||||||||||||||||||||.||||.|||||||.||
  Rat   327 GSAHSILIANIAPERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPVKLPQKELLGPSEA 391

Human   400 KRARGPEEEEIGSPEPMAAPASASQKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQGAPLLSTP 464
            |:|:|||||..||||..|||||||||||.|||||:|||||||.|||::|||.||||||.|||:||
  Rat   392 KKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLGSQGSQGIPLLNTP 456

Human   465 KRERMVLMKTVEEKDLEIERLKTKQKELEAKMLAQKA---EEKENHCPTMLRPLSHRTVTGAKPL 526
            |||||||:||||||:|||||||.||||||||:|||:|   :|||| .||:|:|.|..:.:.||||
  Rat   457 KRERMVLIKTVEEKNLEIERLKMKQKELEAKVLAQEALDPKEKEN-TPTILQPSSSCSGSVAKPL 520

Human   527 KKAVVMPLQLIQEQAASPNAEIHILKNKGRKRKLESLDALEPEEKAEDCWELQISPELLAHGRQK 591
            |||||||||.||:|:.|.| :||:|| ||.||||||....|..||.||.||:||||||||.||:|
  Rat   521 KKAVVMPLQRIQKQSESSN-KIHLLK-KGHKRKLESSHESEAVEKDEDYWEIQISPELLARGRKK 583

Human   592 ILDLLNEGSARDLRSLQRIGPKKAQLIVGWRELHGPFSQVEDLERVEGITGKQMESFLK 650
            :|.|||||||||||||||||.||||||||||||||||::|||||:||||:|||:|||||
  Rat   584 LLHLLNEGSARDLRSLQRIGQKKAQLIVGWRELHGPFNEVEDLEQVEGISGKQVESFLK 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF22	NP_015556.1	KISc_KID_like	43..366	CDD:276827	290/322 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..428		39/48 (81%)
		ComEA	596..646	CDD:441164	44/49 (90%)
Kif22	XP_063142300.1	None