DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tet and TET1

DIOPT Version :9

Sequence 1:NP_001261344.1 Gene:Tet / 38347 FlyBaseID:FBgn0263392 Length:2921 Species:Drosophila melanogaster
Sequence 2:XP_011538506.1 Gene:TET1 / 80312 HGNCID:29484 Length:2165 Species:Homo sapiens


Alignment Length:2919 Identity:627/2919 - (21%)
Similarity:913/2919 - (31%) Gaps:1218/2919 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 DNGP-QPPQTQPHLQLKSGFEPFSKLPSFQSQFHGFNEQLLPDGTPMPVPIGAG----VPPGSAA 301
            |:.| |..|..|.::...|.:..|.|.....:...|..|.:.| :.:.:|..:|    :.||...
Human   156 DSVPMQDTQVLPDIETLIGVQNPSLLKGKSQETTQFWSQRVED-SKINIPTHSGPAAEILPGPLE 219

  Fly   302 AVAAATGSIPPGSVGPNSVAGPVGPTAMSSLQTV-AMSPASISVSSPGMMSVGSPLTQLSSLQT- 364
            ......|.....::...|     |...|.:..|| |..|..   ::|.:.|.|:|..||..|.: 
Human   220 GTRCGEGLFSEETLNDTS-----GSPKMFAQDTVCAPFPQR---ATPKVTSQGNPSIQLEELGSR 276

  Fly   365 -------------------------------------------SITPPS------AGSFPA---- 376
                                                       |.:|.|      |||..|    
Human   277 VESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGA 341

  Fly   377 -PPPPNAF---AHHHALN-------------PHHH--------HRGASGYPTPYAELPLYPGFTP 416
             |....||   |:...::             ||..        |..|.| .||  :||..||..|
Human   342 KPDHQEAFEATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALG-ETP--DLPEIPGAIP 403

  Fly   417 LSVKKEPISGGSDFEMLL-KKEDFDLSNSGGAGL-IHHPLQHGQPHPIPMGMHTPTSYDGNNSNN 479
            :.        |..|..:| ::|...:|.|....| :..|:   .|:||.. .:.|:.:....|..
Human   404 VQ--------GEVFGTILDQQETLGMSGSVVPDLPVFLPV---PPNPIAT-FNAPSKWPEPQSTV 456

  Fly   480 SYPQAAGG-------GSGSHTPHTTTTQPTPTTTTPVKVEKLLQSPIARLEARKKERRKQRPNSL 537
            ||..|..|       ||| |||.:::..           ||....|:..:            :::
Human   457 SYGLAVQGAIQILPLGSG-HTPQSSSNS-----------EKNSLPPVMAI------------SNV 497

  Fly   538 ESSAESEASGMDVDPSNPGQVDAVSSTANFKSPL--------SALGMGDSNDANASGCDKQDYGR 594
            |:..:...|.:   |:|         |..|  ||        ::||:...:.|   |..|.|.|.
Human   498 ENEKQVHISFL---PAN---------TQGF--PLAPERGLFHASLGIAQLSQA---GPSKSDRGS 545

  Fly   595 RHHLPPPT---LNHPPMTLPPPTITITPTTHNHNHQNHNHNHSNDNNSSSCSLFQS--KKKRKRC 654
            .......|   :|...:|:|.|.:                   :.::||..:|..:  |||||||
Human   546 SQVSVTSTVHVVNTTVVTMPVPMV-------------------STSSSSYTTLLPTLEKKKRKRC 591

  Fly   655 GECVGCQRKDNCGECAPCRNDK-SHQICKQRRCEKLTEK-----------------KEPKAKTIV 701
            |.|..||:|.|||||..|:|.| ||||||:|:||:|.:|                 :|.|.|.:.
Human   592 GVCEPCQQKTNCGECTYCKNRKNSHQICKKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLK 656

  Fly   702 FGADGQPVR-PDSKR------GRGKGKSSGSGNGTV--------NATGIAAGNGT---------- 741
            ...|.:||. |.|:.      |.|:.:.......||        :.|||.....|          
Human   657 ADFDNKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTDH 721

  Fly   742 -------------PTTGSRARKNSTKANKLNAAAASATSPRLSPVPAATLLPQQSPNTTSATGNL 793
                         .:..|...|..||:.||...........:..:||.|.:..:..|.......|
Human   722 VKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTL 786

  Fly   794 QQQQQQQQQQYQQHQQLLSQQQLLSQQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQQHQ 858
            :....:..:....|:..:|  .:.:.....:.:.:.....|        ||.......:|...|.
Human   787 ENNSYKFLKDTANHKNAMS--SVATDMSCDHLKGRSNVLVF--------QQPGFNCSSIPHSSHS 841

  Fly   859 IT---AQIQTMKDQPQQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYA 920
            |.   |.|....|||:.|                       :.||...|                
Human   842 IINHHASIHNEGDQPKTP-----------------------ENIPSKEP---------------- 867

  Fly   921 YPSNGYVQSGLGFDPNYGRSPYAAPVQRYDFQSQQLSTAPSAIN-----QVGLQSVAGFAPSYAG 980
                   :.|             :|||            ||.::     ::.|:.|.  |.....
Human   868 -------KDG-------------SPVQ------------PSLLSLMKDRRLTLEQVV--AIEALT 898

  Fly   981 QVSAAPVPPSQQQQQQQQQQQQQHLGADLNKTMS-----GNDTPGYPRVSSVPPRSLNCNGYSGD 1040
            |:|.||...|...:.::.::.:|...:.||...:     ..|... |.:...||:..:|......
Human   899 QLSEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQD-PNLQGEPPKLNHCPSLEKQ 962

  Fly  1041 -------YSGSPATNSNSNNNSSSNTSNTNN----------------SNASNNNATTVVSGGTTT 1082
                   ::|...|.|||:.||::|.::|.:                ||:|..:....::.|..|
Human   963 SSCNTVVFNGQTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIIT 1027

  Fly  1083 PAPPPTVVAQ--PASSPMQPPNQAVPQSPTRSNMLQQQQQQHQSPTGNGLQPYVAPQQQQQ---- 1141
            .......:.|  |.::.::..||.:..    |..|.......|..|...::..||.|..|.    
Human  1028 LDNCSNDLHQLPPRNNEVEYCNQLLDS----SKKLDSDDLSCQDATHTQIEEDVATQLTQLASII 1088

  Fly  1142 -----QQQQQHLSSPPMQDWNWQQQQQQQQSLGGEGYAQGERLHLN-----TRIKSMIMRKSDPK 1196
                 :.:.:.:.|.|........||:..|..|.........:|.|     |:.|:...:|:...
Human  1089 KINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPTQKKTKST 1153

  Fly  1197 DPPPDLQQQPQQVQQQQ---QTGHFLSYSHHLRPEAALSANGPS--SATPTHPLPNLQQQQQQVQ 1256
            ......:::|..|..|:   |....|||.:....:..:::...:  ...| |..|          
Human  1154 PSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCP-HDFP---------- 1207

  Fly  1257 QVQQVQQQQQQQQAVGGQVAAEPIGGGGDHIWKP-HHANSFKKPSVV---------SGYPASQDA 1311
                         .|.|::::      ...|||| ....|..:|..|         ..||.|.:.
Human  1208 -------------TVFGKISS------STKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEE 1253

  Fly  1312 QLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRSKASRAAAAAAAAAEAAAEI 1376
            ::::     :|....::.|                    .|:.|..||.               .
Human  1254 KVKV-----EPLDSLSLFH--------------------LKTESNGKAF---------------T 1278

  Fly  1377 DRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQDYHSQYIKTEPGLLGPPQPNKMEGYERNYQ 1441
            |:..||...     ..::|:...||......||.|                              
Human  1279 DKAYNSQVQ-----LTVNANQKAHPLTQPSSPPNQ------------------------------ 1308

  Fly  1442 NFIQYADFCQNDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASSFQQNFQQNF-------VPGY 1499
                    |.|                         ...|.....|||..::..       :||.
Human  1309 --------CAN-------------------------VMAGDDQIRFQQVVKEQLMHQRLPTLPGI 1340

  Fly  1500 QHSTYGARGKPPANQPHQIHGHGQSLMELDRKPDTNSIIPLPTNYEKDIPAYPIPPHRYALGHGA 1564
            .|.|                                   |||.:               ||    
Human  1341 SHET-----------------------------------PLPES---------------AL---- 1351

  Fly  1565 PPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTRPPTAEHLKDGTCLGLG 1629
                                              .|.|....|..|.|...|             
Human  1352 ----------------------------------TLRNVNVVCSGGITVVST------------- 1369

  Fly  1630 IQPKEELIDEDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKINPMFDTTDRLEKGNKT 1694
                    ..:|.:.:...|......|..|: |...|.......     ||   |.:.:.....:
Human  1370 --------KSEEEVCSSSFGTSEFSTVDSAQ-KNFNDYAMNFFT-----NP---TKNLVSITKDS 1417

  Fly  1695 EIPECEC----FQSDKNPPEPGTYYTHLGTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGK 1755
            |:|.|.|    .|.||.|     ||||||...|:..:|...|.|....|..:|||.:||||||||
Human  1418 ELPTCSCLDRVIQKDKGP-----YYTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGK 1477

  Fly  1756 TSQGCPVAKWVIRRADLEEKILVVVKKRPGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLN 1820
            :|.|||:||||:||:..|||:|.:|::|.||.|..|.:||.::.|||:|...||..|..|...|.
Human  1478 SSHGCPIAKWVLRRSSDEEKVLCLVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLK 1542

  Fly  1821 KY-GLPTTRRCATNENRTCACQGLDPESSGASYSFGCSWSMYYNGCKYARSKTVRKFRLSVKSE- 1883
            .| |.||.|||..||||||.|||:|||:.|||:|||||||||:||||:.||.:.|:||:...|. 
Human  1543 SYNGHPTDRRCTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPL 1607

  Fly  1884 ------------------------------EAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEH 1918
                                          |..:||::..:||.|||::||..|.:|.||.:||:
Human  1608 HTYYERITKGRNPERRYMKPERISPGHEAMEKNLEDNLQSLATRLAPIYKQYAPVAYQNQVEYEN 1672

  Fly  1919 EASDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCTVHVALLKPGNRDTR-LPDDEQFHVL 1982
            .|.:||||.:.|:||||||||||||||.|||:|||.:|.||...|.:..||... :|.|||.|||
Human  1673 VARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVL 1737

  Fly  1983 PLYTMDGTDEFESVEGQRDKHRTGAVQML----DKFPCEVRVRSTPLIPCRRHGKKRKDGDEAAP 2043
            |||.:..||||.|.||...|.::||:::|    .|..|..:       |..|.||||     ||.
Human  1738 PLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPRRKKRTCFTQ-------PVPRSGKKR-----AAM 1790

  Fly  2044 PDG---------DQDAVGDANSQSSSSNGAQSQTQANNQQSSPPALGTAHIKKENGNGVNANGAS 2099
            ...         ::..:.....:::|:      |..|::.||.|.||:           |.....
Human  1791 MTEVLAHKIRAVEKKPIPRIKRKNNST------TTNNSKPSSLPTLGS-----------NTETVQ 1838

  Fly  2100 SKSKGKGKSNQSNNSSASTPG-SAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVHGSNANPQSNGG 2163
            .:.|.:.:.:....||.:|.. |..||.|.|      ....||   .||..|...| |.|     
Human  1839 PEVKSETEPHFILKSSDNTKTYSLMPSAPHP------VKEASP---GFSWSPKTAS-ATP----- 1888

  Fly  2164 QGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTASYIDSRNYYGQW 2228
                          :.|.|.||....|::..                                  
Human  1889 --------------APLKNDATASCGFSERS---------------------------------- 1905

  Fly  2229 PTPHA--PMGMQAQVGGLGGGGPG----GTVAGVPPLTPSTPTAQPQLGVPPATSIAGGTTTGAP 2287
            .|||.  |.|..:........|||    |.||.:|.|  |.|..:|.:...|:|.:         
Human  1906 STPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTL--SAPVMEPLINSEPSTGV--------- 1959

  Fly  2288 TGALPATAPPTATPTQLETSNGYGPGNYQTLVSNPASNLTNPGGVTTEVQQQHQQAQQQSALTGG 2352
                  |.|  .||.|        |.:..:.:::|....::|    .|..:||.:|.:       
Human  1960 ------TEP--LTPHQ--------PNHQPSFLTSPQDLASSP----MEEDEQHSEADE------- 1997

  Fly  2353 VGPGGLPVVGGAPGDLKGRLVSEENPDSTTLVNHHHHHHNLTESKLTALTAMQPMTNLAPLTTSH 2417
                                                                             
Human  1998 ----------------------------------------------------------------- 1997

  Fly  2418 HPQEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPPPHSAYSAYDAYQNMNYNYGYHQAYSPYG 2482
                       ||||                                                  
Human  1998 -----------PPSD-------------------------------------------------- 2001

  Fly  2483 MYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGSANPAAGAGSLISSHGSVASAGVGLQKAMVP 2547
                                                                             
Human  2002 ----------------------------------------------------------------- 2001

  Fly  2548 VPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQQVQQLQQEAPQTILPDLSNGQTNSDTVAT 2612
                                                                             
Human  2002 ----------------------------------------------------------------- 2001

  Fly  2613 PTPTGDSSSNDAGPGNPGAGNQAPASGAGAATTAPPIASPGSTNSTKIEPIGEVAEINENIEAFQ 2677
             .|..|                                .|.|....|:..|.|....:|:|  |.
Human  2002 -EPLSD--------------------------------DPLSPAEEKLPHIDEYWSDSEHI--FL 2031

  Fly  2678 DPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDRHHPTRMTLIFYQHRNLNRCRHGIDEWEEK 2742
            |..:||||||..|||||||||:.|:||||.|..|:|:||||::|:||||:|||:.:||.:.    
Human  2032 DANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFEL---- 2092

  Fly  2743 MRVKKINTDLDNKAKEERERLIKKAAGEDMDELDEDALMQDEPVPIKKESSANGQQLKNGASGSK 2807
                       ||.|.|                                    .::.||     |
Human  2093 -----------NKIKFE------------------------------------AKEAKN-----K 2105

  Fly  2808 KKKSSDSKKSQAN---EQSK--NE--KVALH-APTLTTTSWTTLFP---THPCVVSGKY 2855
            |.|:|:.|...||   |||.  ||  ::..| |.|||..:..|:.|   ||   |:|.|
Human  2106 KMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTH---VAGPY 2161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TetNP_001261344.1 zf-CXXC 646..686 CDD:251032 27/42 (64%)
Tet_JBP 1857..>1990 CDD:289611 73/164 (45%)
Tet_JBP <2676..2727 CDD:289611 33/50 (66%)
TET1XP_011538506.1 zf-CXXC 585..624 CDD:251032 27/38 (71%)
PET <1035..>1057 CDD:297147 5/25 (20%)
Tet_JBP 1580..>1736 CDD:289611 67/155 (43%)
Tet_JBP <2037..2081 CDD:289611 30/43 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 302 1.000 Domainoid score I1397
eggNOG 1 0.900 - - E1_28N65
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S8087
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40386
orthoMCL 1 0.900 - - OOG6_104768
Panther 1 1.100 - - LDO PTHR23358
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.810

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