DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tet and Tet3

DIOPT Version :9

Sequence 1:	NP_001261344.1	Gene:	Tet / 38347	FlyBaseID:	FBgn0263392	Length:	2921	Species:	Drosophila melanogaster
Sequence 2:	XP_008761316.1	Gene:	Tet3 / 680576	RGDID:	1590584	Length:	1802	Species:	Rattus norvegicus

Alignment Length:	2356	Identity:	579/2356 - (24%)
Similarity:	833/2356 - (35%)	Gaps:	764/2356 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   648 KKKRKRCGECVGCQRKDNCGECAPCRNDKSHQICKQRRCEKLTEK----KEPKAKTIVFGADGQP 708
            :|||||||.|..|:|.:|||.|..|.|.::|||||.|:||.|.:|    ||
  Rat    51 RKKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKAGLLKE-------------- 101

  Fly   709 VRPDSKRGRG---KGKSSGSGNGTVNATGIAAG--NGTPTTGSRARKNSTKANKLNAAAASATSP 768
            |..:::.|.|   :|.:..:|:......|...|  :..|.....:|:.||....:|.|...|...
  Rat   102 VEINAREGTGPWAQGATVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAREPAGPS 166

  Fly   769 RLSPVPAATLLPQQSPNTTSATGNLQQQQQQQQQQ---YQQHQQLLSQQQLLSQQQQQY------ 824
            .|.  .|......|.|:..:|:|.....:.:....   :....:.:|....||.:..:.
  Rat   167 LLG--AAGPWRVDQKPDWDAASGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMS 229

  Fly   825 -------QQPQQQQQHFQQQQQQHLQQQHAQQQH-------------LPQQQHQITAQIQT--MK 867
                   :.|:.:......:....||...|..:|             .|.....:..:|::  |:
  Rat   230 REAGNNGRAPRPESCSEGGEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSAAME 294

  Fly   868 DQPQQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYAYPSNGYVQSGLG 932
            ....:|..|....|:....|:...:.....::|| .|.:..| .|.....|.|...|..:|:.:.
  Rat   295 GGQGRPRLPGTLPPSEAGLPAPSTRPLLSSEVPQ-VPPLEGL-PLSQSALSIAKEKNISLQTAIA 357

  Fly   933 FDPNYGRSPYAAPVQRYDFQSQQLSTAPSAINQVGLQSVAGFAPSYAGQVSAAPVP----PSQQQ 993
            .                    :.|:...||:.|          ||::...::.|:|    ||
  Rat   358 I--------------------EALTQLSSALPQ----------PSHSTSQASCPLPEALSPS--- 389

  Fly   994 QQQQQQQQQQHLGADLNKTMSGNDTPGYPRVSSVPPRSLNCNGYSGDYSGSPATNSNSNNNSSSN 1058
              ...:..|.:|.|           |.:|   .|||..     :......|||....:.....|.
  Rat   390 --APFRSPQSYLRA-----------PSWP---VVPPEE-----HPSFAPDSPAFPPATPRTEFSE 433

  Fly  1059 TSNTNNSNASNNNATTVVSGGTTTPAPPP----------------TVVAQPASSPMQP--PNQAV 1105
            ..:|:...|:..|:..|     ..|:|.|                :|..:|.:.|.:|  ..:|.
  Rat   434 AWSTDTPPATPRNSWPV-----PRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAP 493

  Fly  1106 PQSPTRSNMLQQQQQQHQSPTGNGLQPYVAPQQQQQQQQQQHLSSPPMQDWNWQQQQQQQQSLGG 1170
            |.||                         ||......|::..|.|
  Rat   494 PSSP-------------------------APAPSPISQREAPLPS-------------------- 513

  Fly  1171 EGYAQGERLHLNTRIKSMIMRKSDPKDPPPDLQQQPQQVQQQQQTGHFLSYSHHLRP---EAALS 1232
                                       ..||..|:.|...||        :.||.|.   |.|..
  Rat   514 ---------------------------SEPDTHQKAQTALQQ--------HLHHKRNLFLEQAHD 543

  Fly  1233 ANGPSS---------ATPTHPLPNLQQQQQQVQQVQQVQQQQQQQQAVGGQVAAEPIGGGGDHIW 1288
            |:.|:|         |.|..|.|....:..:       :::::.....||.|.||..
  Rat   544 ASFPTSTEPQAPGWWAPPGSPAPRPPDKPPK-------EKKKKPPTPAGGPVGAEKT-------- 593

  Fly  1289 KPHHANSFKKPSVVSGYPASQDAQ------LQLQLQQHQP----GQHTTINHSVDPPVVPPQQHP 1343
            .|....|.:||..:. ...|:|.|      .|:.|:..:|    ||..|   ....||.||
  Rat   594 TPGIKASVRKPIQIK-KSRSRDMQPLFLPVRQIILEGLKPQASEGQAPT---PAQLPVPPP---- 650

  Fly  1344 PVAAAQPKKSRSRSKASRAAAAAAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPP 1408
                           ||:.||:.:.|.....|                |..|.:.|.|......|
  Rat   651 ---------------ASQGAASQSCATPLPPE----------------PSLALFAPSPSGDSLLP 684

  Fly  1409 PGQDYH--SQYIKTEPGLLG---PPQPNKMEGYERNYQNFIQYADFCQNDGQGQPVQQHHGHGQQ 1468
            |.|:..  |..:..:.|..|   ||..:|:|...|.::     |:|..:.|
  Rat   685 PTQEMRSPSPMVALQSGSTGGPLPPADDKLEELIRQFE-----AEFGDSFG-------------- 730

  Fly  1469 DYAGYHHNSAYYGAGASSFQQNFQQNFVPGYQHSTYGARGKPPANQPHQIHGHGQSLMELDRKPD 1533
                                       :||            |.:.|.|             .|:
  Rat   731 ---------------------------LPG------------PPSVPIQ-------------DPE 743

  Fly  1534 TNSIIPLPTNYEKDIPAYPIPPHRYALGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGK 1598
            ..|.. |||      |..|....       :|..:        |||..|.:.......:...||
  Rat   744 NQSTC-LPT------PESPFATR-------SPKKI--------KIESSGAVTVLSTTCFHSEEG- 785

  Fly  1599 PLNNGFSCCRQGGTRPPT-AEHLKDGTCLGLGIQPKEELIDEDELIDTHGNGLKPIGGVGKAKGK 1662
                       |....|| ||:....|..|....|.:.|       ||
  Rat   786 -----------GQEATPTKAENPLTPTLSGFLESPLKYL-------DT----------------- 815

  Fly  1663 QKPDEIPEIVVKHEKINPMFDTTDRLEKGNKTEIPECECFQSDKNPPEPGTYYTHLGTASSLMDL 1727
                             |.....|...|..:.|.|.|:|.:......| |.||||||:..::..:
  Rat   816 -----------------PTKSLLDTPAKKAQAEFPTCDCVEQIVEKDE-GPYYTHLGSGPTVASI 862

  Fly  1728 RREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKKRPGHRCIAAY 1792
            |...|:|....|:.:||||::|||||||:|:|||:|||||||..||||:|.:|:.|.||.|..|.
  Rat   863 RELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAV 927

  Fly  1793 IVVCMVAWDGMPRLEADNAYKNLIPKLNKYGLPTTRRCATNENRTCACQGLDPESSGASYSFGCS 1857
            ||:.::||:|:||...|..|:.|...|.|||.||:|||..|::|||||||.||.:.|||:|||||
  Rat   928 IVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCS 992

  Fly  1858 WSMYYNGCKYARSKTVRKFRLSVKS--EEAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEHEA 1920
            ||||:||||||||||.|||||:..:  ||..:.:....:||.:||::|::.|::|.||...|..|
  Rat   993 WSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVA 1057

  Fly  1921 SDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCTVHVALLKPGNRDT-RLPDDEQFHVLPL 1984
            .||||||:.|:||||||||:|||||:|:|.||:.:||||...|.|..||.. ::|:|||.|||||
  Rat  1058 IDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPL 1122

  Fly  1985 YTMDGTDEFESVEGQRDKHRTGAVQMLDKFPCEVRVRSTPLIPCRRH---------GKKRKDGDE 2040
            |.|..||||.|.|.|..|..:||:|:|..||.|||....|...||:.         .||:...::
  Rat  1123 YKMATTDEFGSEENQNAKVSSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEK 1187

  Fly  2041 AAPPDG-DQDAV---GDANSQSSSSNGAQSQTQANNQQSSPPALGTA---HIK--KENGNGVNAN 2096
            .:.|:. .|:|:   |.......|..|...      ||:..|:|...   |..  |.:||.|
  Rat  1188 LSTPEKIKQEALELAGVTTDPGLSLQGGLP------QQTLKPSLKVEPQNHFSSFKYSGNAV--- 1243

  Fly  2097 GASSKSKGKGKSNQSNNSSASTPGSAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVHGSNANPQSN 2161
                            ..|.|..||..||            :|....|.:|   .|...|
  Rat  1244 ----------------VESYSVLGSCRPS------------DPYSMSSVYS---YHSRYA----- 1272

  Fly  2162 GGQGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTASYIDSRNYYG 2226
                   ||| |.|.|.                          ..|.|:        :.|..|||
  Rat  1273 -------QPG-LASVNG--------------------------FHSKYT--------LPSFGYYG 1295

  Fly  2227 QWPT-----PHAPMGMQAQVGGLGGGGPGGTVAGVPPLTPSTPTAQPQLGVPPATSIAGGTTTGA 2286
             :|:     |...:|..|    .|.||.||:....|.|.....:..|..|             ||
  Rat  1296 -FPSSNPVFPSQFLGPSA----WGHGGGGGSFEKKPDLHALHNSLNPAYG-------------GA 1342

  Fly  2287 PTGALPATAPPTAT--PTQLETSNGY-GPGNY---QTLVSNPASNLTNP-----GGVTTEVQQQH 2340
            ....||..|..|..  |........| ||..|   :....:|||...:|     |.....::|:.
  Rat  1343 EFAELPGQAVSTDNHHPAPHHQQPAYPGPKEYLLPKVPQLHPASRDPSPFAQSSGCYNRSIKQEP 1407

  Fly  2341 ----QQAQQQSALTGGVGPGGLPVV--GGAPGDLKGRLVS--EENPDSTTLVNHH------HHHH 2391
                .||:.....:|.:....||..  .|.||.|.|:...  ..:|..|..|..:      ....
  Rat  1408 VDPLTQAEAVPRDSGKMSRTPLPEASQNGGPGHLWGQYSGGPSMSPKRTNSVGGNWGVFPSGESP 1472

  Fly  2392 NLTESKLTALTAMQPMTNLAPLTTSHHP--QEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPP 2454
            .:...||.:..|       :.||.||.|  |.|....:       .|.:|.:|.......|
  Rat  1473 TIVPDKLNSFGA-------SCLTPSHFPDSQWGLFTGE-------GQQSAPHPGGRLRGKP---- 1519

  Fly  2455 PHSAYSAYDAYQNMNYNYGYHQAYSPYGMYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGSA- 2518
                                   :||.......:....|..|...|.|.......|:..|.|..
  Rat  1520 -----------------------WSPCKFGNGTSALSGPSLPEKPWGMGAGDFNSSLKGGPGFQD 1561

  Fly  2519 ---NPAAGAGSLISSHGSVASAGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQ 2580
               ||                  |.:::..:|.||
  Rat  1562 KLWNP------------------VKVEEGRIPTPG------------------------------ 1578

  Fly  2581 QQQQVQQLQQEAPQTILPDLSNGQTNSDTVATPTPTGDSSSNDAGPGNPGAGNQAPASGAGAATT 2645
                ..|| ::|.|.....||:.:.....:.:.....|..|.:.|                   |
  Rat  1579 ----ANQL-EKAWQAFGMPLSSNEKLFGALKSEEKLWDPFSLEEG-------------------T 1619

  Fly  2646 APPIASPGSTNSTKIEPIGEVAEINENI-----EAFQDPQMGGVAIALNHGSVLIECAKHEMHAT 2705
            |....|.|.....|..|  .|.|..|.:     ..|.|..:||||:|..|.|:|||||:.|:|||
  Rat  1620 AEEPLSKGVVKEEKTGP--GVEEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHAT 1682

  Fly  2706 TAVRRPDRHHPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDLDNKAKEERERLIKKAAGE 2770
            |.:::|:|.||||::|:||||:|||:..||:..||.||:      .|..:|::.:|...:...|:
  Rat  1683 TPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMK------QLAERARQRQEEAARLGLGQ 1741

  Fly  2771 DMDELDEDALMQDEPVPIKKESSANGQQLKNGASGSKKKKSSDSKKSQANEQSKNEKVALHAPT- 2834
                               :|:...|::.|.|.:...:.:..:.|.:....|      ||..||
  Rat  1742 -------------------QEAKLYGKKRKWGGAMVAEPQHKEKKGAVPTRQ------ALAMPTD 1781

  Fly  2835 --LTTTSWTTLFPTHP 2848
              :|.:|:.....|.|
  Rat  1782 SAVTVSSYAYTKVTGP 1797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tet	NP_001261344.1	zf-CXXC	646..686	CDD:251032	22/37 (59%)
		Tet_JBP	1857..>1990	CDD:289611	76/135 (56%)
		Tet_JBP	<2676..2727	CDD:289611	29/50 (58%)
Tet3	XP_008761316.1	zf-CXXC	50..89	CDD:251032	22/37 (59%)
		Tet_JBP	992..>1119	CDD:289611	69/126 (55%)
		Tet_JBP	<1660..1704	CDD:289611	26/43 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1797
eggNOG	1	0.900	-	-		E1_28N65
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002939
OrthoInspector	1	1.000	-	-		otm44521
orthoMCL	1	0.900	-	-		OOG6_104768
Panther	1	1.100	-	-	O	PTHR23358
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900