DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tet and TET2

DIOPT Version :9

Sequence 1:NP_001261344.1 Gene:Tet / 38347 FlyBaseID:FBgn0263392 Length:2921 Species:Drosophila melanogaster
Sequence 2:NP_001120680.1 Gene:TET2 / 54790 HGNCID:25941 Length:2002 Species:Homo sapiens


Alignment Length:2630 Identity:612/2630 - (23%)
Similarity:900/2630 - (34%) Gaps:893/2630 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   454 LQHGQP-----HPIPMG---MHTPTSYDG----NNSNNS-----YPQAAGGGSGS-HTPHTTTTQ 500
            ||:|.|     ||...|   .|:..||.|    ..|.||     :.|.:.|.|.. .......|.
Human    34 LQNGSPLPERAHPEVNGDTKWHSFKSYYGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTV 98

  Fly   501 PTPTTTTPVKVEKLLQSPIARLEAR----KKER---RKQRPNSLESSAESEASGMDVDPSNPGQV 558
            ..|:.:..::::||.|...|..|.|    .:||   ...:||..:.|.:.|:      .|:..|.
Human    99 SEPSLSGLLQIKKLKQDQKANGERRNFGVSQERNPGESSQPNVSDLSDKKES------VSSVAQE 157

  Fly   559 DAVS-----STANFKSP----LSALGMGDSNDANASGCDKQDYGRRHHLPPPTLNHPPMTLPPPT 614
            :||.     ||.|...|    |..|...:...||            :|.....|......|.|..
Human   158 NAVKDFTSFSTHNCSGPENPELQILNEQEGKSAN------------YHDKNIVLLKNKAVLMPNG 210

  Fly   615 ITITPTTHNHNH-----------------------QNH-NHNHSNDNNSSSCSLFQSK------- 648
            .|::.::..|.|                       .:| |..:|...|..||.:....       
Human   211 ATVSASSVEHTHGELLEKTLSQYYPDCVSIAVQKTTSHINAINSQATNELSCEITHPSHTSGQIN 275

  Fly   649 -----------KKRKRCGECVGCQRKDNCGECAPCRNDKSHQICKQRRCEKLTEKKEPKAKTIVF 702
                       |......|.......||..:.|...|     .|..::.|:|.::|.      ||
Human   276 SAQTSNSELPPKPAAVVSEACDADDADNASKLAAMLN-----TCSFQKPEQLQQQKS------VF 329

  Fly   703 GADGQP----VRPDSKRGRGKGKSSGSGNGTVNATGIAAGNGTPTTGSRARKNSTKANKLNAA-- 761
            .....|    ::..:|...|:...||| :..:.|.|          ||..|  ..|.|::|.|  
Human   330 EICPSPAENNIQGTTKLASGEEFCSGS-SSNLQAPG----------GSSER--YLKQNEMNGAYF 381

  Fly   762 -----------AASATSP-----RLSPVPAATLLPQ-QSPNTTSATGNLQQQQQQQQQQYQQHQQ 809
                       :|:.|.|     .|||.|....:|| .|...::..|.:                
Human   382 KQSSVFTKDSFSATTTPPPPSQLLLSPPPPLPQVPQLPSEGKSTLNGGV---------------- 430

  Fly   810 LLSQQQLLSQQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQQHQITAQIQTMKDQPQQPM 874
                                            |::.|    |.|.|.:....:...::.:|:.| 
Human   431 --------------------------------LEEHH----HYPNQSNTTLLREVKIEGKPEAP- 458

  Fly   875 APMAFYPTWQADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYAYPSNGYVQSGLGFDPNYGR 939
                        |||.         |..:..:.|             ||           |....
Human   459 ------------PSQS---------PNPSTHVCS-------------PS-----------PMLSE 478

  Fly   940 SPYAAPVQRYDFQSQQLSTAPSAINQVGLQS--VAGFAPSY--AGQVSAAPVPPSQQQQQQQQQQ 1000
            .|....|.|.|.|:....|.|....:....|  :....|.:  :|::        |...||..:.
Human   479 RPQNNCVNRNDIQTAGTMTVPLCSEKTRPMSEHLKHNPPIFGSSGEL--------QDNCQQLMRN 535

  Fly  1001 QQQHL--GADLNKTMSGND---------TPGYPRVSSVPPRSLNCNGY-SGDYSGSPATNSNSNN 1053
            ::|.:  |.|..:|   .|         .||:..:.:  ||......: ..:.:..|:......|
Human   536 KEQEILKGRDKEQT---RDLVPPTQHYLKPGWIELKA--PRFHQAESHLKRNEASLPSILQYQPN 595

  Fly  1054 NSSSNTSN--TNNSNASNNNATTVVSGGTTTPAPPPTVVAQPASSPMQPPNQAVPQSPTRSNMLQ 1116
            .|:..||.  |.|||                         .|...|.|...|...|...:|.|.|
Human   596 LSNQMTSKQYTGNSN-------------------------MPGGLPRQAYTQKTTQLEHKSQMYQ 635

  Fly  1117 --QQQQQHQSPTGNGLQPYVAPQQQQQQQQQQHLSSPPMQDWNWQQQQQQQQSLGGEGYAQGERL 1179
              ..|.|.|......|| :..|..|....:..||....:|.                  ..|.|.
Human   636 VEMNQGQSQGTVDQHLQ-FQKPSHQVHFSKTDHLPKAHVQS------------------LCGTRF 681

  Fly  1180 HLNTRIKSMIMRKSDPKDPPPDLQQQPQQVQQQQQTGHFLSYSHHL--RPEAALSANGPSSATPT 1242
            |...|..|...:...|.     |:|...  ||..:|..| |.||.|  :|....:...||.:  :
Human   682 HFQQRADSQTEKLMSPV-----LKQHLN--QQASETEPF-SNSHLLQHKPHKQAAQTQPSQS--S 736

  Fly  1243 HPLPNLQQQQQ--QVQQVQQVQQ---------QQQQQQAVGGQVAAEPIGGGGDHIWKPHHANSF 1296
            | ||..|||||  |::..:::.|         .||::.:..||...|...         |..|.:
Human   737 H-LPQNQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTKVEECF---------HGENQY 791

  Fly  1297 KKPSVVSGYPASQDAQLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRSKASR 1361
            .|.|....:      .:|:.|::.|     .||....|                   .|::..|.
Human   792 SKSSEFETH------NVQMGLEEVQ-----NINRRNSP-------------------YSQTMKSS 826

  Fly  1362 AAAAAAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQDYHSQYIKTEPGLLG 1426
            |.....:.:.....:..::..|               .||....|......:|.||.   |..:.
Human   827 ACKIQVSCSNNTHLVSENKEQT---------------THPELFAGNKTQNLHHMQYF---PNNVI 873

  Fly  1427 PPQPNKMEGYERNYQNFIQYADFCQ---NDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASSFQ 1488
            |.|......::...|. .|.|...|   |..|....||.....||.|..::|.:.:.        
Human   874 PKQDLLHRCFQEQEQK-SQQASVLQGYKNRNQDMSGQQAAQLAQQRYLIHNHANVFP-------- 929

  Fly  1489 QNFQQNFVP--GYQHSTYGARGKPPA--NQPH---QIHGHGQSLMELDRKPDTNSIIPLPTNYEK 1546
                   ||  |..|:.     .||.  .|.|   :.|...:...:..::|.|.|   ..:...:
Human   930 -------VPDQGGSHTQ-----TPPQKDTQKHAALRWHLLQKQEQQQTQQPQTES---CHSQMHR 979

  Fly  1547 DIPAYP-IPPHRYALGHGAPP--------------------------------HLSH-------- 1570
            .|...| ..||  |..|.|||                                ||..        
Human   980 PIKVEPGCKPH--ACMHTAPPENKTWKKVTKQENPPASCDNVQQKSIIETMEQHLKQFHAKSLFD 1042

  Fly  1571 HGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTRPPTAEHLKDGTCLGLGIQPKEE 1635
            |..|..|.:....:...|....|                  ||..||..|...|      ...|:
Human  1043 HKALTLKSQKQVKVEMSGPVTVL------------------TRQTTAAELDSHT------PALEQ 1083

  Fly  1636 LIDEDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKINPMFDTTDRLEKGNKTEIPECE 1700
            .....|...|.......:...     .:.|.::.:..:|:     :.||..:    .:.:.|.|.
Human  1084 QTTSSEKTPTKRTAASVLNNF-----IESPSKLLDTPIKN-----LLDTPVK----TQYDFPSCR 1134

  Fly  1701 CFQSDKNPPEPGTYYTHLGTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKW 1765
            |.:......| |.:|||||...::..:|...|||....|:.:|||:::|||||||:|||||:|||
Human  1135 CVEQIIEKDE-GPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKW 1198

  Fly  1766 VIRRADLEEKILVVVKKRPGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLNKYGLPTTRRC 1830
            |:||:..|||:|.:|::|.||.|.||.||:.::.|:|:|...||..|..|...|.|||..|.|||
Human  1199 VVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLSLADKLYSELTETLRKYGTLTNRRC 1263

  Fly  1831 ATNENRTCACQGLDPESSGASYSFGCSWSMYYNGCKYARSKTVRKFRL--SVKSEEAAIEDHMNL 1893
            |.||.|||||||||||:.|||:||||||||||||||:||||..|||:|  ....||..:|.|:..
Human  1264 ALNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQN 1328

  Fly  1894 IATLLAPVFKQVCPRSYDNQTKYEHEASDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCT 1958
            ::||:||.:|::.|.:|:||.:|||.|.:|||||:.|:||||||||||||||:||||||||:|.|
Human  1329 LSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQNGST 1393

  Fly  1959 VHVALLKPGNRD-TRLPDDEQFHVLPLYTMDGTDEFESVEGQRDKHRTGAVQMLDKFPCEVRVRS 2022
            :...|.:..||: ...|:|||.||||||.:...|||.|||.|.:|.|:||:|:|..|..:||:.:
Human  1394 LVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKKRSGAIQVLSSFRRKVRMLA 1458

  Fly  2023 TPLIPCRRHGKKRKDGDEAAPPDGDQDAVGDANSQSSSSNGAQSQTQANNQQSSPPALGTAHIKK 2087
            .|:..||   :::.:..:||           |...||..|                         
Human  1459 EPVKTCR---QRKLEAKKAA-----------AEKLSSLEN------------------------- 1484

  Fly  2088 ENGNGVNANGASSKSKGKGKSNQSNNSSASTPGSAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVH 2152
                                |:..|....|.|.           :|..|.|.|.|          
Human  1485 --------------------SSNKNEKEKSAPS-----------RTKQTENASQA---------- 1508

  Fly  2153 GSNANPQSNGGQGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTAS 2217
                           .|..:|:..:..:|.             ||.|                  
Human  1509 ---------------KQLAELLRLSGPVMQ-------------QSQQ------------------ 1527

  Fly  2218 YIDSRNYYGQWPTPHAPMGMQAQVGGLGGGGPGGTVAGVPPLTPSTPTAQPQLGVPPAT-SIAGG 2281
                            |..:|.|                ||........|.|....|.| |:...
Human  1528 ----------------PQPLQKQ----------------PPQPQQQQRPQQQQPHHPQTESVNSY 1560

  Fly  2282 TTTGAPTGALPATAPPTATPTQLETSNGYG---PGNYQTLVSNPASNLTN--------PGGVTTE 2335
            :.:|:....:....|.:..|....||:.||   |.|:.:..|..|.:..|        ||.:...
Human  1561 SASGSTNPYMRRPNPVSPYPNSSHTSDIYGSTSPMNFYSTSSQAAGSYLNSSNPMNPYPGLLNQN 1625

  Fly  2336 VQQQHQQAQQQSALTGGVGPGGLPVVGGAPGDLKGRLVSEENPDSTTLVNHHHHHHNLTESKLTA 2400
            .|....|..           |.|.|...:|      .:...:|.|..:             .|..
Human  1626 TQYPSYQCN-----------GNLSVDNCSP------YLGSYSPQSQPM-------------DLYR 1660

  Fly  2401 LTAMQPMTNLA--PLTTSHHPQEGFVKPKPPPSDYTAQYTAQY-------------------PNN 2444
            ..:..|::.|:  |:.|.:.|:.|          .:..:|::|                   ||.
Human  1661 YPSQDPLSKLSLPPIHTLYQPRFG----------NSQSFTSKYLGYGNQNMQGDGFSSCTIRPNV 1715

  Fly  2445 YQMYPPPPPPPHSAYSAYDAYQNMNYNYGYHQAYSPYGMYPQQTPPPTPPPPSPNWNMYGHHQTG 2509
            :.:...||.|.|          .|:.::          |......||....|:.::....||...
Human  1716 HHVGKLPPYPTH----------EMDGHF----------MGATSRLPPNLSNPNMDYKNGEHHSPS 1760

  Fly  2510 SVNSGYGSANPAAGAGSLISSH------GSVASAGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQ 2568
            .:...| ||.|.....||.:.|      ..::....||.| |:|.   |:|.:...:|....:..
Human  1761 HIIHNY-SAAPGMFNSSLHALHLQNKENDMLSHTANGLSK-MLPA---LNHDRTACVQGGLHKLS 1820

  Fly  2569 QQQQQQQQQQQQQQQQVQQLQQEAPQTILPDLSNGQTNSDTVATPTPTGDSSSNDAGPGNPGAGN 2633
            ....|::|                |..::..:::|..::|.|     ..||.             
Human  1821 DANGQEKQ----------------PLALVQGVASGAEDNDEV-----WSDSE------------- 1851

  Fly  2634 QAPASGAGAATTAPPIASPGSTNSTKIEPIGEVAEINENIEAFQDPQMGGVAIALNHGSVLIECA 2698
                                                    ::|.||.:||||:|..|||:|||||
Human  1852 ----------------------------------------QSFLDPDIGGVAVAPTHGSILIECA 1876

  Fly  2699 KHEMHATTAVRRPDRHHPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDLDNKAKEERERL 2763
            |.|:||||.::.|:|:||||::|:||||:::|..:||:..||.||.         .||:|:.|..
Human  1877 KRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAKMA---------EKAREKEEEC 1932

  Fly  2764 IKKAAGEDMDELDEDALMQDEPVPIKKESSANGQQLKNGASGSKKKKSSDSKKSQANEQSK---N 2825
            .|  .|.|.             ||.|              |..||.|...::..:.:|.:.   .
Human  1933 EK--YGPDY-------------VPQK--------------SHGKKVKREPAEPHETSEPTYLRFI 1968

  Fly  2826 EKVALHAPTLTTTSWTTLFPTHPCVVSGKY 2855
            :.:|....::||.|..|..|.....|:|.|
Human  1969 KSLAERTMSVTTDSTVTTSPYAFTRVTGPY 1998

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TetNP_001261344.1 zf-CXXC 646..686 CDD:251032 7/57 (12%)
Tet_JBP 1857..>1990 CDD:289611 78/135 (58%)
Tet_JBP <2676..2727 CDD:289611 32/50 (64%)
TET2NP_001120680.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..154 11/46 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..287 0/20 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..368 8/29 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..488 28/195 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 703..748 19/50 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..949 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1075..1095 4/25 (16%)
Tet_JBP 1290..>1417 CDD:315517 72/126 (57%)
Interaction with DNA 1290..1303 11/12 (92%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1475..1507 12/98 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1521..1587 18/128 (14%)
Tet_JBP <1853..1905 CDD:315517 32/51 (63%)
2-oxoglutarate binding. /evidence=ECO:0000269|PubMed:24315485 1896..1898 1/1 (100%)
Substrate binding. /evidence=ECO:0000269|PubMed:24315485 1902..1904 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1932..1961 10/57 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 302 1.000 Domainoid score I1397
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 549 1.000 Inparanoid score I1149
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002939
OrthoInspector 1 1.000 - - otm40386
orthoMCL 1 0.900 - - OOG6_104768
Panther 1 1.100 - - O PTHR23358
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
66.050

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