DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tet and Tet2

DIOPT Version :9

Sequence 1:	NP_001261344.1	Gene:	Tet / 38347	FlyBaseID:	FBgn0263392	Length:	2921	Species:	Drosophila melanogaster
Sequence 2:	XP_006233409.1	Gene:	Tet2 / 310859	RGDID:	1311625	Length:	1959	Species:	Rattus norvegicus

Alignment Length:	2594	Identity:	589/2594 - (22%)
Similarity:	880/2594 - (33%)	Gaps:	875/2594 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 TPHTTTTQ--------PTPTT-TTPVKVEKLLQSPIARLEARKKERRKQRPNSLESSAESEASGM 548
            |.|...|:        |:|.: |.|:.|:....||:|           :||:.
  Rat     6 TTHAEGTRQSPFLIASPSPVSHTEPLAVKLQNGSPLA-----------ERPHP------------ 47

  Fly   549 DVDPSNPGQVDAVSSTANFKSPLSALGMGDSNDANA-----------SGCDKQDYGRRHHLPPPT 602
                    :|:..:...:|:|......|..|..::.           ||| .|:.|.:..:..|:
  Rat    48 --------EVNGDTKWQSFQSYYGIPHMKGSQSSHESPDFIHEGRGYSGC-LQNGGIKRTVSEPS 103

  Fly   603 LN----HPPMTLPPPTITITPTTHNHNHQNHNHNHSNDNNSSSCSLFQSKKKRKRCGECVGCQRK 663
            |:    :..:||          ......:::|...|.:.|....|
  Rat   104 LSGLHLNTKLTL----------DQKAKGESNNFGESQEGNPGKSS-------------------- 138

  Fly   664 DNCGECAPCRNDKSHQICKQRRCEKLTEKKEPKAKTIVFGA--DGQPVR----------PDSKRG 716
                         ||.     ....|::.:||...|.....  |..|.|          |:.:.|
  Rat   139 -------------SHP-----NVSGLSDDREPGTSTAQESTDIDAFPTRNYNGVENTEIPEEQEG 185

  Fly   717 RG-------KGKSSGSGNG-TVNATGIAAGNGTPTTGSRARKNSTKANKLNAAAASATSPRLSPV 773
            ..       |.|:....|| ||:|..:     ..|.|....|.....:.::.|..:.|:|.::.:
  Rat   186 GNDRNALLLKNKAVLMPNGATVSAPSV-----EDTHGEFLEKTQCYPDCVSMAVQNNTTPHVNAL 245

  Fly   774 --PAATLLPQQ--SPNTTSATGNLQQQQQQQQQ----------------------------QYQQ 806
              .||..||::  .|:.|||..|..|....|..                            |..:
  Rat   246 SGQAAIELPREITQPSLTSAQINFSQTSSAQLPPEPAAMVTKACDLDSASKPAGVLGTCAFQKAE 310

  Fly   807 HQQ--------------LLSQQQLLSQQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQ-- 855
            |||              :..|.......::.|.......|......:|.::|:.....:..|.
  Rat   311 HQQKSVLGIGPSSCAENINIQGNTKPFAEEYYAGSDSDLQTSLGSSEQCIKQKETNGAYFRQSSV 375

  Fly   856 --QHQITAQIQTMKDQPQQPMAPMAFYPTWQADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQS 918
              :..|:|...|    |..| :|:|..|..|. ||:|          :.|     ||.:..: :.
  Rat   376 FPEDSISATTMT----PPSP-SPLAPRPVLQL-PSEG----------KGT-----LNDVALE-EH 418

  Fly   919 YAYPSNGYVQSGLGFDPNYGRSPYAAPVQRYDFQSQQLSTAPSAINQVGLQSVAGFAPSYAGQVS 983
            :.||:..        |....|........:....||.|:|:..
  Rat   419 HRYPNQS--------DLTLSREGKTEHQPKKTTSSQSLNTSVH---------------------- 453

  Fly   984 AAPVPPSQQQQQQQQQQQQQHLGADLNKTMSGNDTPGYPRVSSVPPRS-------------LNCN 1035
             .|.||....:|.|                  ||        .|||.|             |..:
  Rat   454 -TPNPPLMLPEQHQ------------------ND--------CVPPCSEKTRKVSDYRMYYLPNH 491

  Fly  1036 GYSGDYSGSPATNSNSNNNSSSNTSNTNNSNASNNNATTVVSGGTTTPAPPPTVVAQPASSPMQP 1100
            |:.||...:.........:.....:|...:..|                    |:|.|....::.
  Rat   492 GHGGDLQENSQYLMGHGEHEILKDANKGQTQGS--------------------VLAAPGWIELKA 536

  Fly  1101 P--NQAVPQSPTRSNMLQQQQQQHQSPTG--NGLQ--------------PYVAPQQQQQQQQQQH 1147
            .  ::|:.|:..::..|....:...|||.  ..:|              ||:....|.:.:.|.:
  Rat   537 SHFHKALHQTECKATSLHSGLRYQTSPTNQIGSIQSTGSVNMTGEFQRPPYIQKTAQPEHKSQMY 601

  Fly  1148 L------SSPPMQDWNWQQQQQQQQ------SLGGEGYAQGERLHLNTRIKSMIMRKSDPKDPPP 1200
            .      .||.|.|.:.|.|:...|      .|..|  |.|.:.|.:.|:           ||..
  Rat   602 QVEMNQGPSPGMGDQHLQFQKTSYQECISRTDLPPE--AHGPQYHFHQRV-----------DPST 653

  Fly  1201 DLQQQPQQVQQQQQTGHFLSYSHH---LRPEAALSANGPSSATPTHPL--PNLQQQQQQVQQVQQ 1260
            |    .||..:.:....||.::.|   .:.:|:.::|.|......|.|  .|.:|..|....:..
  Rat   654 D----KQQATEAELFSSFLQHTPHKQAAQTQASQNSNFPQVCQQQHQLQRKNKEQMPQTFSHLHG 714

  Fly  1261 VQQQQQQQQAVGGQVAAEPIGGGGDHIWKP-----HHA----------------------NSFKK 1298
            ...:|.|.|.. |.:.||....|.:...||     |.|                      ||.|.
  Rat   715 TNHEQSQGQCF-GTIKAEESFCGENQYSKPSNFQTHSAQGGLEQVQNVNRSFPYAKIETPNSSKV 778

  Fly  1299 PSVVSGY--PAS----QDAQLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRS 1357
            .::.|.|  |||    |:..|.|.:....|.|..|   ...|..|.|.|.......|.::.:...
  Rat   779 QTLCSNYTHPASESREQNLHLDLFIGNRTPNQQNT---QCFPNNVTPSQDVAHRCFQEQEQKPHQ 840

  Fly  1358 KASRAAAAAAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQ-DYHSQYIKTE 1421
                     |::.:......||..|..|.    :...|.|..|..|...|.|.| ..|:|
  Rat   841 ---------ASSLQGLKGRSRDEFSVPPA----EATQARYLVHIQAKALPVPKQGGSHTQ----- 887

  Fly  1422 PGLLGPPQPNKMEGYERNYQNFIQYADFCQNDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASS 1486
               :.|.:..:.....|..        ..|...| |.:||     .|..:|:|
  Rat   888 ---ISPQKDTQKHAALRRL--------LLQKQEQ-QQIQQ-----SQSESGHH------------ 923

  Fly  1487 FQQNFQQNFVPG-----YQHSTYGARGKPPANQPHQIHGHGQSLMELDRKPDTNSIIPLPTNYEK 1546
             |........||     .:|.|.|    |..|.|.:|. ....|:..| ...|.|||   ...|:
  Rat   924 -QMPRPIKIEPGSKLSSCKHPTSG----PQENMPKRIK-QESPLLSCD-GGRTESII---ETMER 978

  Fly  1547 DIPAYPIPPHRYALGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGG 1611
            .:..:.:..            |..:.:|....:..|.:.........|||
  Rat   979 HLKQFQLKA------------LCDYKILTLNSQRQGDVETATNARSAGSE--------------- 1016

  Fly  1612 TRPPTAE---HLKDGTCLGLGIQPKEELIDE--DELIDTHGNGLKPIGGVG---------KAKGK 1662
            ...|.||   .|.:.|       |.:...|.  .::.::..:...|:..:.         |.|.:
  Rat  1017 NHTPAAEPQASLSEKT-------PTKRTADSVLTDVSESPSDSDTPVEDISCEACKNAAEKRKKR 1074

  Fly  1663 QKPDEIPEIVVKHEKINPMFDTTDRLEKGNKTEIPECECFQSDKNPPEPGTYYTHLGTASSLMDL 1727
            :|..:.....:...|..|......|..|....|..|             |.||||||...::..:
  Rat  1075 KKRSQNNSNRMVQRKSGPSKAKQRRKRKRRSNEKDE-------------GPYYTHLGAGPNVAAI 1126

  Fly  1728 RREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKKRPGHRCIAAY 1792
            |...|||....|:.:|||:::|||||||:|||||:||||.||:..|||:|.:|:.|..|.|..|.
  Rat  1127 RTIMEERFGEKGKAIRIERVIYTGKEGKSSQGCPIAKWVYRRSSTEEKLLCLVRVRAKHTCDTAV 1191

  Fly  1793 IVVCMVAWDGMPRLEADNAYKNLIPKLNKYGLPTTRRCATNENRTCACQGLDPESSGASYSFGCS 1857
            ||:.::.|||:|:..|...|..|...|:..|:.|.||||.||||.|.|||.:||:.|||:|:|||
  Rat  1192 IVIVILLWDGIPKPLASELYSELTEILSNRGICTNRRCAQNENRNCCCQGENPETCGASFSYGCS 1256

  Fly  1858 WSMYYNGCKYARSKTVRKFRL--SVKSEEAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEHEA 1920
            |||||||||:||||..|||||  ....||..:..|:..:||::||::|::.|.:|.||.::||.|
  Rat  1257 WSMYYNGCKFARSKNPRKFRLHGDEPKEEEKLGSHLQNLATVIAPIYKKLAPDAYRNQVEFEHRA 1321

  Fly  1921 SDCRLGLEPGKPFSGVTACLDFCAHSHRDLHNMQDGCTVHVALLKPGNRDT-RLPDDEQFHVLPL 1984
            .:|||||:.|:|||||||||||.||:|||..||.:|.||.|.|.:..||:. ..|:|||.|||||
  Rat  1322 IECRLGLKEGRPFSGVTACLDFSAHAHRDQQNMANGSTVVVTLTREDNREVGGQPEDEQLHVLPL 1386

  Fly  1985 YTMDGTDEFESVEGQRDKHRTGAVQMLDKFPCEVRVRSTPLIPCRRHGKKRKDGDEAAPPDGDQD 2049
            ||:...|||.|.|||.:|...|::|:|..|.             ||..::..|     ||
  Rat  1387 YTIATEDEFGSTEGQEEKILQGSIQVLHSFR-------------RRRVRRLVD-----PP----- 1428

  Fly  2050 AVGDANSQSSSSNGAQSQTQANNQQSSPPALGTAHIKKENGNGVNANGASSKSKGKGKSNQSNNS 2114
                       .|..|.:.:|               ||       |...||......|:.:..:|
  Rat  1429 -----------KNCRQKKLEA---------------KK-------ARKLSSLENCSNKNEKEKSS 1460

  Fly  2115 SASTPGSAPPSTPSPRCQTPVTNNPSPAGSAFSTPPVHGSNANPQSNGGQGTGNQPGQLMSSNSS 2179
            |.:.|                                                      |.:.|.
  Rat  1461 SRTRP------------------------------------------------------MENASP 1471

  Fly  2180 LMNMATMIDTFTDAQLQSNQISSTVLDSPYSYDYQTASYIDSRNYYGQWPTPHAPMGMQAQVGGL 2244
            ::.|.        |||   ::|.:|:..|.|.          :.:..|...|..|.
  Rat  1472 MIQMT--------AQL---RLSGSVIQQPQSL----------QRHLQQVQRPPQPQ--------- 1506

  Fly  2245 GGGGPGGTVAGVPPLTPSTPTAQPQLGVPPATSIAGGTTTGAPTGALPATAPPTATPTQLETSNG 2309
                        ||        |||..:|..:...|..::|:....:...||.:..|:....::.
  Rat  1507 ------------PP--------QPQHILPSNSQPVGSHSSGSTNVYMRQPAPLSPYPSSSHAADM 1551

  Fly  2310 YGPGNYQT----------LVSNPASNLTNPGGVTTEVQQQHQQAQQQSALTGGVGPGGLPVVGGA 2364
            ||..|:..          |..:| ||..||.........|:..:|...:::...||   |.:|
  Rat  1552 YGDANHVNFHPTSSHAAGLYLSP-SNSMNPYPGLFNQNNQYAASQCNGSMSADSGP---PFLG-- 1610

  Fly  2365 PGDLKGRLVSEENPDSTTLVNHHH----HHHNLTESKLTALTAMQPMTNLAPLTTSHHPQEGFVK 2425
                      ..:|.|.:...|.:    |..||               ||.|:.|.:
  Rat  1611 ----------PYSPQSQSRGLHRYPNQDHLSNL---------------NLPPIHTLY-------- 1642

  Fly  2426 PKPPPSDYTAQYTAQY--PNNYQM-------YPPPPPPPH-SAYSAYDAYQNMNYNYGYHQAYSP 2480
              |..||...:| ..|  .||.|.       .|..|...| ..:|:| |...|:.::....:..|
  Rat  1643 --PQRSDSPFKY-LNYGNQNNVQRDRDAFTNCPLKPNVHHLPTFSSY-ATPKMDGHFMGAASRLP 1703

  Fly  2481 YGMYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGSANPAAGAGSLISS----HGS-----VAS 2536
            |.            .|:..:....||....:..||    |.|.:||:.||    |..     |:.
  Rat  1704 YS------------HPNMEYKSSDHHLPPHMIHGY----PTAASGSVSSSSHAFHNKENDNMVSH 1752

  Fly  2537 AGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQQVQQLQQEAPQTILPDLS 2601
            ...||.:.:   ||..|.:....                               :.|...|||.|
  Rat  1753 TANGLSRVL---PGFNHDRTASA-------------------------------QGPLYSLPDYS 1783

  Fly  2602 NGQTNSDTVATPTPTGDSSSNDAGPGNPGAGNQAPASGAGAATTAPPIASPGSTNSTKIEPIGEV 2666
            ..:                       .||...|..||                     :|.|...
  Rat  1784 QEK-----------------------QPGVSGQDGAS---------------------VEDIEVW 1804

  Fly  2667 AEINENIEAFQDPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDRHHPTRMTLIFYQHRNLNR 2731
            ::...|   ||||.:||||||..|||:||||||.|:||||.|.:|:|..|.|::|:||||:|||.
  Rat  1805 SDSEHN---FQDPSIGGVAIAPTHGSILIECAKCEVHATTKVNKPNRKKPARISLVFYQHKNLNE 1866

  Fly  2732 CRHGIDEWEEKMRVKKINTDLDNKAKEERERLIKKAAGEDMDELDEDALMQDEPVPIKKESSANG 2796
            .:|.:..||.||.         .||::|.         |:.::...|.:.|
  Rat  1867 PKHSLAVWEAKMA---------GKARKEE---------EECEKYGSDHVSQ-------------- 1899

  Fly  2797 QQLKNGASGSKKKKSSDSKKSQANEQSKNEKVALHAPTLTTTSWTTLFPTHPCVVSGKY 2855
               ||.....|::.:...:..:.:.......:|.:..::||.|..|..|.....|:|.|
  Rat  1900 ---KNHGKRVKREPTGPQETPKPSYLRFIHSLAENTVSMTTDSTVTTRPYAFTQVTGPY 1955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tet	NP_001261344.1	zf-CXXC	646..686	CDD:251032	2/39 (5%)
		Tet_JBP	1857..>1990	CDD:289611	76/135 (56%)
		Tet_JBP	<2676..2727	CDD:289611	33/50 (66%)
Tet2	XP_006233409.1	Tet_JBP	1107..>1439	CDD:394797	172/393 (44%)
Tet2	XP_006233409.1	Tet_JBP	<1800..1892	CDD:394797	48/112 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1797
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1377
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002939
OrthoInspector	1	1.000	-	-		otm44521
orthoMCL	1	0.900	-	-		OOG6_104768
Panther	1	1.100	-	-	O	PTHR23358
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050