|
Fly 147 NNGNNSNPDGSNTTVPAPLGSSNNSSSNHANAASGGNSGQRHGDANANAISAASAAVGNPGNQQP 211
::||:|.| |...|.:| .:.|.:.........|.| |....:.:..:..:.:.:...||.:.
Rat 145 HSGNDSGP--SQDAVMSP--DTENLTGEQNMCLVEGES-QEITQSCSQTVEDSQSCISEYGNLEA 204
Fly 212 --------NNSAG-NANSNSNSNSNSN-GSYTRPW----EMESKDNGPQ------PPQTQPHLQL 256
.:|.| .::..||:.|||: |....|. |:.|:.|... .|...|.|.
Rat 205 GISWSLEGTHSEGLLSHQTSNNVSNSHPGCAPSPQRSTSEVTSEKNASDQFVDLCSPVESPKLS- 268
Fly 257 KSGFEPFSKLPSFQSQFHGFNEQLLPDGTPMPVP---------IGAGVPPGSAAAVAAATGSIP- 311
:| |:.|. |......||.:...|| :...|.| :|.......||.|
Rat 269 ----DP-SQNPM------GSEHNCFPDSSFRIVPELDLKTCMSLDESVYP-TALIKFILAGSQPD 321
Fly 312 --------------PGSVG--PNSV--AGPVGPTAMSSL------------QTVAMSPASISVSS 346
|..|| ||.| |..:...|.|:| .:..::..|:|...
Rat 322 VLDTKSEEETLKTTPEKVGSHPNQVVDATSILGQAFSTLPHQWGFPGANLVHSETLAKGSVSPED 386
Fly 347 PGMMSVGSPLTQLSSLQTSI-TPPSAGSFPAPPPPNAFAHHHAL--NPHHHHRGASGY----PTP 404
.|.::: |.|..:|...: .||....| .|.|||..|.:..| .|..|...:.|. .||
Rat 387 LGAITM---LNQPETLGMDMDAPPDLPIF-LPMPPNTVATYSCLLSGPEPHTSASCGLEVQGATP 447
Fly 405 YAELPLYPGFTPLSVKKEPISGGSDFEMLLKKEDFDLSNSGGAGLIHHPLQHGQPHPIPMGMHTP 469
. |.|..|.||...:...: |...:::...........||.|....:|.....|.....|.|
Rat 448 I--LTLDSGHTPQPPQNSEL---SSVPLVIAANSTQAEKQFGANLFPANIQGFTIAPENELQHAP 507
Fly 470 TSYDGNNSNNSYPQAAGGGSGSHTPHTTTTQPTPTTTTPVKVEKLLQSPIARLEARKKERRKQRP 534
.|....:::.|....||. ||...|::......| ::..|:.|
Rat 508 --LDLTQGSHAAPSKLEGGI-SHVSMTSSADDVKAT--------MMSMPVTR------------- 548
Fly 535 NSLESSAESEASGMDVDPSNPGQVDAVSSTANFKSPLSALGMGDSNDANASGCDKQDYGRRHHLP 599
:||::.
Rat 549 ---------------------------ASTSSL-------------------------------- 554
Fly 600 PPTLNHPPMTLPPPTITITPTTHNHNHQNHNHNHSNDNNSSSCSLFQSKKKRKRCGECVGCQRKD 664
|....|||: .::|||.||.|..||:|.
Rat 555 -------PCKSMPPTV-------------------------------ERRKRKACGVCEPCQQKA 581
Fly 665 NCGECAPCRNDK-SHQICKQRRCEKLTEK-----------------KEPKAKTIVFGADGQPVRP 711
|||||..|:|.| ||||||:|:||.|.:| :|.|.|.:....:.:||..
Rat 582 NCGECTYCKNRKNSHQICKKRKCEVLKKKPEATSRVQVTKENKRPQREKKPKVLKTDFNNKPVNG 646
Fly 712 D-------SKRGRGK---------------GKSSGSGNGTVNATGIAAGNGTPTTGSRARKNSTK 754
. |:||.|: .|::| ..|||.....||...|.......|
Rat 647 PKSESMDYSRRGHGEEEQRLGLFTHPLENVRKNAG------GMTGIEVEKWTPNKKSHLAAGQVK 705
Fly 755 ANK-LNAAAASATSPRLSPVPAATLLPQQSPNTTSATGNLQQQQQQQQQQYQQHQQLLSQQQLLS 818
.:: .|.|....:.| |
Rat 706 GSRGANLAGVENSQP-------------------------------------------------S 721
Fly 819 QQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQQHQITAQIQTMKDQPQQPMAPMAFYPTW 883
:..:|...|. ||:
Rat 722 EDDKQQTNPS----------------------------------------------------PTF 734
Fly 884 QADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYAYPSNGYVQSGLGFDPNYGRSPYAAPVQR 948
......|.:| :..:|.:|. ..||.|..:..|....:|
Rat 735 AQTVRNGMKN--VHCLPTDTD--LPLNKLSHEEFSKVLGNN------------------------ 771
Fly 949 YDFQSQQLSTAPSAINQVGLQSVAGFAPSYAGQVSAAPVPPSQQQQQQQQQQQQQHLGADLNKTM 1013
|.:|.|.||..... ......::...||....|..:
Rat 772 ----SSKLLTDPSDCKDA--------------------------MSDTTSREGCDHLKGPRNIVL 806
Fly 1014 SGNDTPGYPRVSSVPPRSLNCNGYSGDYSGSPATNSNSNNNSSSNTSNTNNSNASNNNATTVVSG 1078
. ..|| |||. ||:.:| ..||:..|..:|
Rat 807 F--QKPG-----------LNCR------SGAEST-------------------IFNNHPDTHSTG 833
Fly 1079 GTTTPAPPPTVVAQPASSPMQPPNQAVPQSPTRSNMLQQQQ-------------QQHQSPTGNGL 1130
....| |...|.:.|....|..|:..::::.:: |..::|:.|..
Rat 834 SQHQP---------PEKVPNKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQLSEAPSENSS 889
Fly 1131 QPYVAPQQQQQQQQQQHLSS---------PPMQDWNWQQQQQQQQSLGGEGYAQGERLHLNTRIK 1186
.......::..|:....|:| ...||.| .||:.||.:|
Rat 890 PSKTEKDEETDQRTASLLNSCKDVLHSVRKDFQDPN----------------VQGKSLHHDT--- 935
Fly 1187 SMIMRKSDPKDPPPDLQQQPQQVQQQQQTGHFLSYSHHLRPEAALS-ANGPS---SATPTHPLPN 1247
::....:.....||.....|.: ..|:.:...|.|..| |:|.: |:..:.|||.
Rat 936 -VVFNGQNRAFKSPDSFATNQAL--------IKSHEYSRSPTAGKSIASGKAPLDSSKNSCPLPE 991
Fly 1248 LQQQQQQVQQVQQVQQ---------QQQQQQAVGGQVAAE--PIGGGGDHIWKPHHANSFKKP-S 1300
..|..:...||....| |......:...|||: .:....:|| .|...|:...| |
Rat 992 ESQNLENFSQVLICDQNLNSHDPSCQDAPYSQIEEDVAAQLTQLASTINHI-NPEFRNAESTPES 1055
Fly 1301 VVSGYPASQDAQLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRSKASRAAAA 1365
:|:.....:.:|.:..:||..| ::|.:. |:|| :.:|||::.:::.:...:.
Rat 1056 LVAKNTQQKHSQEKRMVQQKPP---SSIQNK---PIVP--------STKPKKTQKKARPTPYTSK 1106
Fly 1366 AAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQDYHSQYIKTEPGLLGPPQP 1430
....|.|.:..:.|:...: .|:..| ...|..:|.::....|...|
Rat 1107 RKKKAPAHSSQESDQKKQE-------RLAIEY-------------SKMHDIWISSQFQRFGQSGP 1151
Fly 1431 NKMEGYERNYQNFIQYADFCQNDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASSFQQNFQ--- 1492
..:....||...|.|.. :|| .|.....|.|..:.......|.:|.:
Rat 1152 RSLPVLLRNIPIFDQIL---------KPV-------TQSKTSSHPNKLFPPINQIKFTRNPELAK 1200
Fly 1493 -------QNFVP--GYQHSTYGARGKPPANQPHQIHGHGQSLMELDRKPDTNSIIPLPTNYEKDI 1548
.:.:| .::..:.|.....||: :..||.::.:|:|
Rat 1201 ETVKVEPSDSLPTCQFKMESSGQAFSEPAD-----NSQGQPMVNVDQK----------------- 1243
Fly 1549 PAYPIPPHRYALGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTR 1613
|:|:|. :||......: |.|....:.:||:....::. ..
Rat 1244 -AHPLPQ--------SPPSNQCANI---------MAGAAQTHFHLGARKNLVHQ---------IP 1281
Fly 1614 PPTAEHLKDGTCLGLGIQPKEELIDEDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKI 1678
|||.. ||.| |.|:....:.|:. |.|..:.| |..:..|||:.
Rat 1282 PPTLP----------GISP-------DPLLPDPASALRK-GNVLSSNG------ITVVTTKHEEA 1322
Fly 1679 -----NPMFDTTDRLE---KGN-----------------KTEIPECECFQSDKNP-PEPGTYYTH 1717
.|...|||..: .|| :.|...|:|.:.|..| .:.|.||||
Rat 1323 QTSSNGPSDPTTDSAQADFNGNVMDFLSMPAKKLIAELKEQEAATCQCARPDGGPQKDKGPYYTH 1387
Fly 1718 LGTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKK 1782
||...|:..:|...|.|....|:.:||||||:||||||:|||||||||||||:..|||::.:|::
Rat 1388 LGAGPSVAAVRELMETRYGQKGKAIRIEKIVFTGKEGKSSQGCPVAKWVIRRSGPEEKVICLVRE 1452
Fly 1783 RPGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLNKY-GLPTTRRCATNENRTCACQGLDPE 1846
|..|.|..|.|||.::.|:|:|||.||..||.|...|..| |.||.|||..|:.|||.|||.:|:
Rat 1453 RVDHYCSTAVIVVLILLWEGIPRLMADRLYKELTENLRSYSGHPTDRRCTLNKKRTCTCQGTNPK 1517
Fly 1847 SSGASYSFGCSWSMYYNGCKYARSKTVRKFRLS-------------------------------- 1879
:.|||:|||||||||:||||:.||...|||||:
Rat 1518 TCGASFSFGCSWSMYFNGCKFGRSANPRKFRLAPNYPLHDYYKRITGRCSEGSDVKTGWIIPERK 1582
Fly 1880 --VKSEEAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEHEASDCRLGLEPGKPFSGVTACLDF 1942
:..||..:|:::..:||:||||:||:.|.:|.||.:||..|.|||||.|.|:||||||.|:||
Rat 1583 TLISREEKQLEENLQDLATVLAPVYKQMAPVAYQNQVEYEDIAGDCRLGNEEGRPFSGVTCCMDF 1647
Fly 1943 CAHSHRDLHNMQDGCTVHVALLKPGNRDTRLPDDEQFHVLPLYTMDGTDEFESVEGQRDKHRTGA 2007
|||||:|:|||.:|.||...|::...||..:|.|||.||||||.:..||||.||||.:.|.::||
Rat 1648 CAHSHKDIHNMNNGSTVVCTLIREDGRDRSVPGDEQLHVLPLYRLADTDEFGSVEGMKAKIQSGA 1712
Fly 2008 VQMLDKFPCEVR--VRSTPLIPCRRHGK-KRKDGDEAAPPDGDQDAVGDANSQSSSSNGAQSQTQ 2069
:|: ..|...| ..|.|:..|.:..| |.||
Rat 1713 IQV--NGPTRKRRLCFSEPVPRCGKRAKMKEKD-------------------------------- 1743
Fly 2070 ANNQQSSPPALGTAHIKKENGNGVNANGASSKSKGKGKSNQSNNSSASTPGSAPPSTPSPRCQTP 2134
|::| |.|.|.| .:||.|.|: |
Rat 1744 -----------------KKSG----ATGLSKK-----------RNSACTKGA------------P 1764
Fly 2135 VTNNPSPAGSAFSTP-PVHGSNANPQSNGGQGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSN 2198
.::|.....||.||| ||...:.: |...|..|.
Rat 1765 GSHNTKIYSSASSTPHPVKDESTD--------------------------------FCPLQASST 1797
Fly 2199 QISSTVLDSPYSYDYQTASYIDSRNYYGQWPTPHAPMGMQAQVGGLGGGGPGGTVAGVPPLTPST 2263
:.|:.:.: :||| ||.|
Rat 1798 ETSTCMYN-------KTAS----------------------------GGFP-------------- 1813
Fly 2264 PTAQPQLGVPPATSIAGGTTTGAPTGALPATAPPTATPTQLETSNGYGPGNYQTLVSNPASNLTN 2328
|||: ..:.|.
Rat 1814 -----------------------------------------ETSS--------------ILHCTM 1823
Fly 2329 PGGVTTEVQQQHQQAQQQSALTGGVGPGGLPVVGGAPGDLKGRLVSEENPDSTTLVNHHHHHHNL 2393
|.|. |..| ..|||:..| :|.
Rat 1824 PSGA-------HSGA------------------NAAPGECTG------------IVQ-------- 1843
Fly 2394 TESKLTALTAMQPMTNLAPLTTSHHPQEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPPPHSA 2458
|.:::.|| ||.:
Rat 1844 TAAEVAAL-----------------------------------------------------PHQS 1855
Fly 2459 YSAYDAYQNMNYNYGYHQAYSPYGMYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGSANPAAG 2523
....|: |....|.|.|| .|.|.:
Rat 1856 LPIADS--------------------PLHAEPLTSPP---------DHLTSN------------- 1878
Fly 2524 AGSLISSHGSVASAGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQQVQQL 2588
|..||:..|
Rat 1879 --------------------------------------------------------QSNQQLPFL 1887
Fly 2589 QQEAPQTILPDLSNGQTNSDTVATPTPTGDSSSNDAGPGNPGAGNQAPASGAGAATTAPPIASPG 2653
.:||.:.......:.:|:|...|.|..
Rat 1888 --SSPQKLASCQVEDERHSETDEPPQPED------------------------------------ 1914
Fly 2654 STNSTKIEPIGEVAEINE----NIEAFQDPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDRH 2714
|.:.:::| :.|.:.||..||||||..|||||||||:.|:||||::..|.|.
Rat 1915 ----------GNIPQLDEFWSDSEEIYNDPAFGGVAIAPIHGSVLIECARKELHATTSLSSPKRE 1969
Fly 2715 HPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDLDNKAKEERE 2761
.|.|::|:||||:|||:..||.|....|.:.||:. .|...:||
Rat 1970 VPFRVSLVFYQHKNLNKPNHGFDINRIKCKCKKVT----KKPPADRE 2012
| 
