DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tet and Tet1

DIOPT Version :9

Sequence 1:	NP_001261344.1	Gene:	Tet / 38347	FlyBaseID:	FBgn0263392	Length:	2921	Species:	Drosophila melanogaster
Sequence 2:	XP_038955252.1	Gene:	Tet1 / 309902	RGDID:	1310993	Length:	2058	Species:	Rattus norvegicus

Alignment Length:	2842	Identity:	595/2842 - (20%)
Similarity:	880/2842 - (30%)	Gaps:	1201/2842 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 NNGNNSNPDGSNTTVPAPLGSSNNSSSNHANAASGGNSGQRHGDANANAISAASAAVGNPGNQQP 211
            ::||:|.|  |...|.:|  .:.|.:.........|.| |....:.:..:..:.:.:...||.:.
  Rat   145 HSGNDSGP--SQDAVMSP--DTENLTGEQNMCLVEGES-QEITQSCSQTVEDSQSCISEYGNLEA 204

  Fly   212 --------NNSAG-NANSNSNSNSNSN-GSYTRPW----EMESKDNGPQ------PPQTQPHLQL 256
                    .:|.| .::..||:.|||: |....|.    |:.|:.|...      .|...|.|.
  Rat   205 GISWSLEGTHSEGLLSHQTSNNVSNSHPGCAPSPQRSTSEVTSEKNASDQFVDLCSPVESPKLS- 268

  Fly   257 KSGFEPFSKLPSFQSQFHGFNEQLLPDGTPMPVP---------IGAGVPPGSAAAVAAATGSIP- 311
                :| |:.|.      |......||.:...||         :...|.| :|.......||.|
  Rat   269 ----DP-SQNPM------GSEHNCFPDSSFRIVPELDLKTCMSLDESVYP-TALIKFILAGSQPD 321

  Fly   312 --------------PGSVG--PNSV--AGPVGPTAMSSL------------QTVAMSPASISVSS 346
                          |..||  ||.|  |..:...|.|:|            .:..::..|:|...
  Rat   322 VLDTKSEEETLKTTPEKVGSHPNQVVDATSILGQAFSTLPHQWGFPGANLVHSETLAKGSVSPED 386

  Fly   347 PGMMSVGSPLTQLSSLQTSI-TPPSAGSFPAPPPPNAFAHHHAL--NPHHHHRGASGY----PTP 404
            .|.:::   |.|..:|...: .||....| .|.|||..|.:..|  .|..|...:.|.    .||
  Rat   387 LGAITM---LNQPETLGMDMDAPPDLPIF-LPMPPNTVATYSCLLSGPEPHTSASCGLEVQGATP 447

  Fly   405 YAELPLYPGFTPLSVKKEPISGGSDFEMLLKKEDFDLSNSGGAGLIHHPLQHGQPHPIPMGMHTP 469
            .  |.|..|.||...:...:   |...:::...........||.|....:|.....|.....|.|
  Rat   448 I--LTLDSGHTPQPPQNSEL---SSVPLVIAANSTQAEKQFGANLFPANIQGFTIAPENELQHAP 507

  Fly   470 TSYDGNNSNNSYPQAAGGGSGSHTPHTTTTQPTPTTTTPVKVEKLLQSPIARLEARKKERRKQRP 534
              .|....:::.|....||. ||...|::......|        ::..|:.|
  Rat   508 --LDLTQGSHAAPSKLEGGI-SHVSMTSSADDVKAT--------MMSMPVTR------------- 548

  Fly   535 NSLESSAESEASGMDVDPSNPGQVDAVSSTANFKSPLSALGMGDSNDANASGCDKQDYGRRHHLP 599
                                       :||::.
  Rat   549 ---------------------------ASTSSL-------------------------------- 554

  Fly   600 PPTLNHPPMTLPPPTITITPTTHNHNHQNHNHNHSNDNNSSSCSLFQSKKKRKRCGECVGCQRKD 664
                   |....|||:                               .::|||.||.|..||:|.
  Rat   555 -------PCKSMPPTV-------------------------------ERRKRKACGVCEPCQQKA 581

  Fly   665 NCGECAPCRNDK-SHQICKQRRCEKLTEK-----------------KEPKAKTIVFGADGQPVRP 711
            |||||..|:|.| ||||||:|:||.|.:|                 :|.|.|.:....:.:||..
  Rat   582 NCGECTYCKNRKNSHQICKKRKCEVLKKKPEATSRVQVTKENKRPQREKKPKVLKTDFNNKPVNG 646

  Fly   712 D-------SKRGRGK---------------GKSSGSGNGTVNATGIAAGNGTPTTGSRARKNSTK 754
            .       |:||.|:               .|::|      ..|||.....||...|.......|
  Rat   647 PKSESMDYSRRGHGEEEQRLGLFTHPLENVRKNAG------GMTGIEVEKWTPNKKSHLAAGQVK 705

  Fly   755 ANK-LNAAAASATSPRLSPVPAATLLPQQSPNTTSATGNLQQQQQQQQQQYQQHQQLLSQQQLLS 818
            .:: .|.|....:.|                                                 |
  Rat   706 GSRGANLAGVENSQP-------------------------------------------------S 721

  Fly   819 QQQQQYQQPQQQQQHFQQQQQQHLQQQHAQQQHLPQQQHQITAQIQTMKDQPQQPMAPMAFYPTW 883
            :..:|...|.                                                    ||:
  Rat   722 EDDKQQTNPS----------------------------------------------------PTF 734

  Fly   884 QADPSQGWQNQFIQQIPQNTPAITSLNSLDFQTQSYAYPSNGYVQSGLGFDPNYGRSPYAAPVQR 948
            ......|.:|  :..:|.:|.  ..||.|..:..|....:|
  Rat   735 AQTVRNGMKN--VHCLPTDTD--LPLNKLSHEEFSKVLGNN------------------------ 771

  Fly   949 YDFQSQQLSTAPSAINQVGLQSVAGFAPSYAGQVSAAPVPPSQQQQQQQQQQQQQHLGADLNKTM 1013
                |.:|.|.||.....                          ......::...||....|..:
  Rat   772 ----SSKLLTDPSDCKDA--------------------------MSDTTSREGCDHLKGPRNIVL 806

  Fly  1014 SGNDTPGYPRVSSVPPRSLNCNGYSGDYSGSPATNSNSNNNSSSNTSNTNNSNASNNNATTVVSG 1078
            .  ..||           |||.      ||:.:|                   ..||:..|..:|
  Rat   807 F--QKPG-----------LNCR------SGAEST-------------------IFNNHPDTHSTG 833

  Fly  1079 GTTTPAPPPTVVAQPASSPMQPPNQAVPQSPTRSNMLQQQQ-------------QQHQSPTGNGL 1130
            ....|         |...|.:.|....|..|:..::::.::             |..::|:.|..
  Rat   834 SQHQP---------PEKVPNKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQLSEAPSENSS 889

  Fly  1131 QPYVAPQQQQQQQQQQHLSS---------PPMQDWNWQQQQQQQQSLGGEGYAQGERLHLNTRIK 1186
            .......::..|:....|:|         ...||.|                .||:.||.:|
  Rat   890 PSKTEKDEETDQRTASLLNSCKDVLHSVRKDFQDPN----------------VQGKSLHHDT--- 935

  Fly  1187 SMIMRKSDPKDPPPDLQQQPQQVQQQQQTGHFLSYSHHLRPEAALS-ANGPS---SATPTHPLPN 1247
             ::....:.....||.....|.:        ..|:.:...|.|..| |:|.:   |:..:.|||.
  Rat   936 -VVFNGQNRAFKSPDSFATNQAL--------IKSHEYSRSPTAGKSIASGKAPLDSSKNSCPLPE 991

  Fly  1248 LQQQQQQVQQVQQVQQ---------QQQQQQAVGGQVAAE--PIGGGGDHIWKPHHANSFKKP-S 1300
            ..|..:...||....|         |......:...|||:  .:....:|| .|...|:...| |
  Rat   992 ESQNLENFSQVLICDQNLNSHDPSCQDAPYSQIEEDVAAQLTQLASTINHI-NPEFRNAESTPES 1055

  Fly  1301 VVSGYPASQDAQLQLQLQQHQPGQHTTINHSVDPPVVPPQQHPPVAAAQPKKSRSRSKASRAAAA 1365
            :|:.....:.:|.:..:||..|   ::|.:.   |:||        :.:|||::.:::.:...:.
  Rat  1056 LVAKNTQQKHSQEKRMVQQKPP---SSIQNK---PIVP--------STKPKKTQKKARPTPYTSK 1106

  Fly  1366 AAAAAEAAAEIDRDRNSTDPGGGGLKPLSAHYPPHPHAAGGPPPGQDYHSQYIKTEPGLLGPPQP 1430
            ....|.|.:..:.|:...:       .|:..|             ...|..:|.::....|...|
  Rat  1107 RKKKAPAHSSQESDQKKQE-------RLAIEY-------------SKMHDIWISSQFQRFGQSGP 1151

  Fly  1431 NKMEGYERNYQNFIQYADFCQNDGQGQPVQQHHGHGQQDYAGYHHNSAYYGAGASSFQQNFQ--- 1492
            ..:....||...|.|..         :||       .|.....|.|..:.......|.:|.:
  Rat  1152 RSLPVLLRNIPIFDQIL---------KPV-------TQSKTSSHPNKLFPPINQIKFTRNPELAK 1200

  Fly  1493 -------QNFVP--GYQHSTYGARGKPPANQPHQIHGHGQSLMELDRKPDTNSIIPLPTNYEKDI 1548
                   .:.:|  .::..:.|.....||:     :..||.::.:|:|
  Rat  1201 ETVKVEPSDSLPTCQFKMESSGQAFSEPAD-----NSQGQPMVNVDQK----------------- 1243

  Fly  1549 PAYPIPPHRYALGHGAPPHLSHHGMLEPKIEDMGMLGHGGGYAYLGSEGKPLNNGFSCCRQGGTR 1613
             |:|:|.        :||......:         |.|....:.:||:....::.         ..
  Rat  1244 -AHPLPQ--------SPPSNQCANI---------MAGAAQTHFHLGARKNLVHQ---------IP 1281

  Fly  1614 PPTAEHLKDGTCLGLGIQPKEELIDEDELIDTHGNGLKPIGGVGKAKGKQKPDEIPEIVVKHEKI 1678
            |||..          ||.|       |.|:....:.|:. |.|..:.|      |..:..|||:.
  Rat  1282 PPTLP----------GISP-------DPLLPDPASALRK-GNVLSSNG------ITVVTTKHEEA 1322

  Fly  1679 -----NPMFDTTDRLE---KGN-----------------KTEIPECECFQSDKNP-PEPGTYYTH 1717
                 .|...|||..:   .||                 :.|...|:|.:.|..| .:.|.||||
  Rat  1323 QTSSNGPSDPTTDSAQADFNGNVMDFLSMPAKKLIAELKEQEAATCQCARPDGGPQKDKGPYYTH 1387

  Fly  1718 LGTASSLMDLRREFEERCNLTGRQLRIEKIVYTGKEGKTSQGCPVAKWVIRRADLEEKILVVVKK 1782
            ||...|:..:|...|.|....|:.:||||||:||||||:|||||||||||||:..|||::.:|::
  Rat  1388 LGAGPSVAAVRELMETRYGQKGKAIRIEKIVFTGKEGKSSQGCPVAKWVIRRSGPEEKVICLVRE 1452

  Fly  1783 RPGHRCIAAYIVVCMVAWDGMPRLEADNAYKNLIPKLNKY-GLPTTRRCATNENRTCACQGLDPE 1846
            |..|.|..|.|||.::.|:|:|||.||..||.|...|..| |.||.|||..|:.|||.|||.:|:
  Rat  1453 RVDHYCSTAVIVVLILLWEGIPRLMADRLYKELTENLRSYSGHPTDRRCTLNKKRTCTCQGTNPK 1517

  Fly  1847 SSGASYSFGCSWSMYYNGCKYARSKTVRKFRLS-------------------------------- 1879
            :.|||:|||||||||:||||:.||...|||||:
  Rat  1518 TCGASFSFGCSWSMYFNGCKFGRSANPRKFRLAPNYPLHDYYKRITGRCSEGSDVKTGWIIPERK 1582

  Fly  1880 --VKSEEAAIEDHMNLIATLLAPVFKQVCPRSYDNQTKYEHEASDCRLGLEPGKPFSGVTACLDF 1942
              :..||..:|:::..:||:||||:||:.|.:|.||.:||..|.|||||.|.|:||||||.|:||
  Rat  1583 TLISREEKQLEENLQDLATVLAPVYKQMAPVAYQNQVEYEDIAGDCRLGNEEGRPFSGVTCCMDF 1647

  Fly  1943 CAHSHRDLHNMQDGCTVHVALLKPGNRDTRLPDDEQFHVLPLYTMDGTDEFESVEGQRDKHRTGA 2007
            |||||:|:|||.:|.||...|::...||..:|.|||.||||||.:..||||.||||.:.|.::||
  Rat  1648 CAHSHKDIHNMNNGSTVVCTLIREDGRDRSVPGDEQLHVLPLYRLADTDEFGSVEGMKAKIQSGA 1712

  Fly  2008 VQMLDKFPCEVR--VRSTPLIPCRRHGK-KRKDGDEAAPPDGDQDAVGDANSQSSSSNGAQSQTQ 2069
            :|:  ..|...|  ..|.|:..|.:..| |.||
  Rat  1713 IQV--NGPTRKRRLCFSEPVPRCGKRAKMKEKD-------------------------------- 1743

  Fly  2070 ANNQQSSPPALGTAHIKKENGNGVNANGASSKSKGKGKSNQSNNSSASTPGSAPPSTPSPRCQTP 2134
                             |::|    |.|.|.|           .:||.|.|:            |
  Rat  1744 -----------------KKSG----ATGLSKK-----------RNSACTKGA------------P 1764

  Fly  2135 VTNNPSPAGSAFSTP-PVHGSNANPQSNGGQGTGNQPGQLMSSNSSLMNMATMIDTFTDAQLQSN 2198
            .::|.....||.||| ||...:.:                                |...|..|.
  Rat  1765 GSHNTKIYSSASSTPHPVKDESTD--------------------------------FCPLQASST 1797

  Fly  2199 QISSTVLDSPYSYDYQTASYIDSRNYYGQWPTPHAPMGMQAQVGGLGGGGPGGTVAGVPPLTPST 2263
            :.|:.:.:       :|||                            ||.|
  Rat  1798 ETSTCMYN-------KTAS----------------------------GGFP-------------- 1813

  Fly  2264 PTAQPQLGVPPATSIAGGTTTGAPTGALPATAPPTATPTQLETSNGYGPGNYQTLVSNPASNLTN 2328
                                                     |||:              ..:.|.
  Rat  1814 -----------------------------------------ETSS--------------ILHCTM 1823

  Fly  2329 PGGVTTEVQQQHQQAQQQSALTGGVGPGGLPVVGGAPGDLKGRLVSEENPDSTTLVNHHHHHHNL 2393
            |.|.       |..|                  ..|||:..|            :|.
  Rat  1824 PSGA-------HSGA------------------NAAPGECTG------------IVQ-------- 1843

  Fly  2394 TESKLTALTAMQPMTNLAPLTTSHHPQEGFVKPKPPPSDYTAQYTAQYPNNYQMYPPPPPPPHSA 2458
            |.:::.||                                                     ||.:
  Rat  1844 TAAEVAAL-----------------------------------------------------PHQS 1855

  Fly  2459 YSAYDAYQNMNYNYGYHQAYSPYGMYPQQTPPPTPPPPSPNWNMYGHHQTGSVNSGYGSANPAAG 2523
            ....|:                    |....|.|.||         .|.|.:
  Rat  1856 LPIADS--------------------PLHAEPLTSPP---------DHLTSN------------- 1878

  Fly  2524 AGSLISSHGSVASAGVGLQKAMVPVPGPLHHQQQQVLQQQQQQQQQQQQQQQQQQQQQQQQVQQL 2588
                                                                    |..||:..|
  Rat  1879 --------------------------------------------------------QSNQQLPFL 1887

  Fly  2589 QQEAPQTILPDLSNGQTNSDTVATPTPTGDSSSNDAGPGNPGAGNQAPASGAGAATTAPPIASPG 2653
              .:||.:.......:.:|:|...|.|..
  Rat  1888 --SSPQKLASCQVEDERHSETDEPPQPED------------------------------------ 1914

  Fly  2654 STNSTKIEPIGEVAEINE----NIEAFQDPQMGGVAIALNHGSVLIECAKHEMHATTAVRRPDRH 2714
                      |.:.:::|    :.|.:.||..||||||..|||||||||:.|:||||::..|.|.
  Rat  1915 ----------GNIPQLDEFWSDSEEIYNDPAFGGVAIAPIHGSVLIECARKELHATTSLSSPKRE 1969

  Fly  2715 HPTRMTLIFYQHRNLNRCRHGIDEWEEKMRVKKINTDLDNKAKEERE 2761
            .|.|::|:||||:|||:..||.|....|.:.||:.    .|...:||
  Rat  1970 VPFRVSLVFYQHKNLNKPNHGFDINRIKCKCKKVT----KKPPADRE 2012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tet	NP_001261344.1	zf-CXXC	646..686	CDD:251032	24/40 (60%)
		Tet_JBP	1857..>1990	CDD:289611	75/166 (45%)
		Tet_JBP	<2676..2727	CDD:289611	30/50 (60%)
Tet1	XP_038955252.1	Chlamy_inclu_1	1051..>1128	CDD:411607	17/97 (18%)
		Tet_JBP	1368..1995	CDD:394797	286/1084 (26%)
		zf-CXXC	565..604	CDD:366873	24/38 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44521
orthoMCL	1	0.900	-	-		OOG6_104768
Panther	1	1.100	-	-	LDO	PTHR23358
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.000