DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tet and Cxxc5

DIOPT Version :9

Sequence 1:	NP_001261344.1	Gene:	Tet / 38347	FlyBaseID:	FBgn0263392	Length:	2921	Species:	Drosophila melanogaster
Sequence 2:	NP_001007629.1	Gene:	Cxxc5 / 291670	RGDID:	1359466	Length:	316	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	81/308 - (26%)
Similarity:	110/308 - (35%)	Gaps:	97/308 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   471 SYDGNNSNNSYPQAAGGGSGSHTPHTTTTQPTPTTTTPVKVEKLLQSPIAR------LEARKKER 529
            |.|...|::|...::..|||.....|..: .|...|.|..|......|..|      .|...|..
  Rat     8 SQDAGGSSSSSNTSSSSGSGQKAGGTDKS-ATVAATAPASVADDAPPPERRNKSGIISEPLNKSL 71

  Fly   530 RKQRPNSLESSAESE-----------------------------ASGMDVDPSNP------GQVD 559
            |:.||.|..||..|.                             |:.|.||.|||      |.|.
  Rat    72 RRSRPLSHYSSFGSSGGAGSMMGGESADKAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVA 136

  Fly   560 AVSSTANFKSPLSALGMGDSNDANASGCDKQDYGR---------RHHLP---------P------ 600
            ::.|.|...:.|:|.|.          ...|.:.:         :.|||         |
  Rat   137 SLLSKAERATELAAEGQ----------LTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVA 191

  Fly   601 -----------PTLNHPPMTLPPPTITITPT----THNHNHQNHNHNHSNDNNSSSCSLFQSKKK 650
                       |.|...|:.  |....:||.    ..:..|......:......:| ::...|||
  Rat   192 GAEALNGQSDFPYLGAFPIN--PGLFIMTPAGVFLAESALHMAGLAEYPMQGELAS-AISSGKKK 253

  Fly   651 RKRCGECVGCQRKDNCGECAPCRNDKS-HQICKQRRCEKLTEKKEPKA 697
            |||||.|..|:|:.||.:|:.|||.|: |||||.|:||:|  ||:|.|
  Rat   254 RKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEEL--KKKPSA 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tet	NP_001261344.1	zf-CXXC	646..686	CDD:251032	24/40 (60%)
		Tet_JBP	1857..>1990	CDD:289611
		Tet_JBP	<2676..2727	CDD:289611
Cxxc5	NP_001007629.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		23/87 (26%)
		zf-CXXC	249..290	CDD:366873	24/40 (60%)
		Nuclear localization signal. /evidence=ECO:0000255	251..256		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000